幽门螺杆菌在胃黏膜中不同形态感染的病理研究
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摘要
目的探讨胃黏膜中不同形态幽门螺杆菌感染引起的胃部疾病的病理特点,降低胃部幽门螺杆菌感染率。方法选取2011年4月-2014年3月行胃黏膜活检的患者219例,采用不同的染色方法观察幽门螺杆菌的形态,并观察胃黏膜的形影病理学改变;采用SPSS13.0软件进行分析。结果螺旋状伴球形幽门螺杆菌男性患者所占比例明显高于单纯球形幽门螺杆菌患者,两种形态幽门螺杆菌之间差异有统计学意义(P<0.05);两种形态幽门螺杆菌患者黏膜类型、炎症类型以及是否伴有异型增生差异无统计学意义;螺旋状伴球形幽门螺杆菌有炎症活动、重度炎症、有滤泡形成者分别占79.35%、55.43%和50.00%;单纯球形幽门螺杆菌患者分别占43.75%、25.00%和25.00%,螺旋状伴球形幽门螺杆菌明显高于单纯球形螺杆菌,两种形态比较差异有统计学意义(P<0.05)。结论球形幽门螺杆菌与螺旋状幽门螺杆菌均对胃黏膜具有致病性,且螺旋状幽门螺杆菌的致病性更强,而男性存在该形态螺杆菌相对较多,临床应予以注意。
OBJECTIVE To explore the pathological characteristics of gastric diseases induced by the gastric mucosa with different forms of Helicobacter pylori infections so as to reduce the incidence of gastric infection with H.pylori.METHODS A total of 219 patients who underwent the gastric mucosa biopsy from Apr 2011 to Mar 2014 were enrolled in the study.The morphology of the H.pylori strains was described by using different staining methods,and the pathological changes of the gastric mucosa were observed.The statistical analysis was performed with the use of SPSS13.0software.RESULTS The proportion of the male patients complicated with spiral and spherical H.pylori infection was significantly higher than that of the patients with single spherical H.pylori infection,with significant difference(P<0.05).There was no statistically significant difference in the type of mucosa,type of inflammation,or complication of dysplasia between the patients complicated with spiral and spherical H.pyloriinfection and the patients with single H.pylori infection.Among the patients complicated with spiral and spherical H.pylori infection,79.35% had inflammatory activity,55.43% had severe inflammation,and 50.00% had follicular formation.Among the patients with single spherical H.pylori infection,43.75% had the inflammatory activity,25.00% had severe inflammation,and 25.00% had follicular formation;the incidence of the spiral and spherical H.pylori infection was significantly higher than that of the single H.pylori infection,with significant difference(P<0.05).CONCLUSIONBoth the spherical H.pylori and the spiral H.pylori show the pathogenicity of gastric mucosa,and the pathogenicity of the spiral H.pyloriis even higher.The spiral H.pyloriis prevalent in the male patients,which should be paid attention to.
OBJECTIVE To explore the pathological characteristics of gastric diseases induced by the gastric mucosa with different forms of Helicobacter pylori infections so as to reduce the incidence of gastric infection with H.pylori.METHODS A total of 219 patients who underwent the gastric mucosa biopsy from Apr 2011 to Mar 2014 were enrolled in the study.The morphology of the H.pylori strains was described by using different staining methods,and the pathological changes of the gastric mucosa were observed.The statistical analysis was performed with the use of SPSS13.0software.RESULTS The proportion of the male patients complicated with spiral and spherical H.pylori infection was significantly higher than that of the patients with single spherical H.pylori infection,with significant difference(P<0.05).There was no statistically significant difference in the type of mucosa,type of inflammation,or complication of dysplasia between the patients complicated with spiral and spherical H.pyloriinfection and the patients with single H.pylori infection.Among the patients complicated with spiral and spherical H.pylori infection,79.35% had inflammatory activity,55.43% had severe inflammation,and 50.00% had follicular formation.Among the patients with single spherical H.pylori infection,43.75% had the inflammatory activity,25.00% had severe inflammation,and 25.00% had follicular formation;the incidence of the spiral and spherical H.pylori infection was significantly higher than that of the single H.pylori infection,with significant difference(P<0.05).CONCLUSIONBoth the spherical H.pylori and the spiral H.pylori show the pathogenicity of gastric mucosa,and the pathogenicity of the spiral H.pyloriis even higher.The spiral H.pyloriis prevalent in the male patients,which should be paid attention to.
引文
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[5]隋昕珂,吴本俨,李园,等.老年幽门螺杆菌相关性胃炎患者抗幽门螺杆菌根除治疗前后的病理学研究[J].中华老年多器官疾病杂志,2012,11(5):341-344.
[6]Fujimoto Y,Shimoyama A,Saeki A,et al.Innate immunomodulation by lipophilic termini of lipopolysaccharide;synthesis of lipid as from porphyromonas gingivalis and other bacteria and their immunomodulative responses[J].Mol Biosyst,2013,9(5):987-996.
[7]Malekshahi ZV,Gargari SL,Rasooli I,et al.Treatment of Helicobacter pylori infection in mice with oral administration of egg yolk-driven anti-UreC immunoglobulin[J].Microbial Pathogenesis,2011,51(5):366-372.
[2]Lv SX,Gan JH,Ma XG,et al.Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier:an 8years endoscopic follow-up study[J].Hepatogastroenterology,2012,59(115):947-950.
[3]Carvalho MA,Machado NC,Ortolan EV,et al.Upper gastrointestinal histopathological findings in children and adolescents with nonulcer dyspepsia with helicobacter pylori infection[J].J Pediatr Gastroenterol Nutr,2012,55(5):523-529.
[4]Masaharu Mita,Masahiko Satoh,Akinori Shimada,et al.Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori.[J].J Toxicol Sci,2012,37(6):1261-1265.
[5]隋昕珂,吴本俨,李园,等.老年幽门螺杆菌相关性胃炎患者抗幽门螺杆菌根除治疗前后的病理学研究[J].中华老年多器官疾病杂志,2012,11(5):341-344.
[6]Fujimoto Y,Shimoyama A,Saeki A,et al.Innate immunomodulation by lipophilic termini of lipopolysaccharide;synthesis of lipid as from porphyromonas gingivalis and other bacteria and their immunomodulative responses[J].Mol Biosyst,2013,9(5):987-996.
[7]Malekshahi ZV,Gargari SL,Rasooli I,et al.Treatment of Helicobacter pylori infection in mice with oral administration of egg yolk-driven anti-UreC immunoglobulin[J].Microbial Pathogenesis,2011,51(5):366-372.