脂联素的心血管生物学功能研究进展
摘要
<正>中国心血管病(cardiovascular diseases,CVD)死亡占城乡居民总死亡原因的首位~([1])。心血管病患病危险因素为多方面,如糖尿病、肥胖等。脂联素,一个重要的脂肪细胞分泌的脂肪细胞因子,具胰岛素增敏和抗炎症、抗氧化活性等。目前诸多研究发现脂联素对心血管疾病具有保护作用。现对脂联素与心血管疾病的研究进展进行综述。一、脂联素的结构及表达人脂联素基因编码位于染色体3q27,是糖尿
引文
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[14]Ouchi N,Kihara S,Funashashi T,et al.Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.Circulation,2003,107:671-674.
[15]Xu A,Vanhoutte PM.Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease[J].Am J Physiol Heart Circ Physiol,2012,302:1231-1240.
[16]Lovren F,Pan Y,Quan A,et al.Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages[J].Am J Physiol Heart Circ Physiol,2010,299:656-663.
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[18]Ouchi N,Walsh K.Adiponectin as an antiinflammatory factor[J].Clin Chim Acta,2007,380:24–30.
[19]Szmitko PE,Wang CH,Weisel RD,et a1.New markers of inflammation and endothelial cell activation part I[J].Circulation,2003,108:1917–1923.
[20]Chen SJ,Yen CH,Huang YC,et a1.Relationships between inflammation,adiponectin,and oxidative stress in metabolic syn-drome[J].PLo S One,2012,7:e45693.
[21]Furukawa S,Fujita T,Shimabukuro M,et al.Increased oxidative stress in obesity and its impact on metabolic syndrome[J].J Clin Invest,2004,114:1752-1761.
[22]He QR,Yu T,Li P.Association of oxidative stress and serum adiponectin in patients with metabolic syndrome[J].Sichuan Da Xue Xue Bao Yi Xue Ban,2009,40:623-627.
[23]Jacobsen DW.Hyperhomocysteinemia and oxidative stress time for a reality check?[J].Arterioscler Thromb Vasc Biol,2000,20:1182-1184.
[24]Alexander J K,Alister Pw Funnell1,et al.Adipokines and insulin action-A sensitive issue[J].Landes Bioscience,2014,3:88–96.
[25]Bruun JM,Lihn AS,Verdich C,et a1.Regulation of adiponectin by adipose tissue-derived cytokines:in vivo and in vitro investigations in humans[J].Am J Physiol Endocrinol Metab,2003,285:527-533.
[26]Wijesekara N,Krishnamurthy M,Bhattacharjee A,et a1.Adiponectininduced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion[J].J Biol Chem,2010,285:33623-33631.
[27]Han SH,Quon MJ,Koh KK.Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction[J].Curr Opin Lipidol,2007,18:58-65.
[28]Kumada M,Kihara S,Koh KK,et al.Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages[J].Circulation,2004,109:2046-2049.
[2]Maryam Esfahani,Ahmad Movahedian.Adiponectin:an adipokine with protective features against metabolic syndrome[J].Iran J Basic Med Sci,2015,18:430-442.
[3]Hui X Y,Karen SL Lam1,et al.Adiponectin and cardiovascular health:an update[J].British J Pharmacology,2012,165:574-590.
[4]Bahceci M,Gokalp D,Bahcecis et a1.The correlation between adiposity and adiponectin,tumor necrosis factor alpha,interleukin-6 and high sensitivity C-reactive protein levels.Is adipocyte size associated with inflammation in adults?[J].J Endocrinol Invest,2007,30:210-214.
[5]Matsubara M,Maruoka S,Katayose S.Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women[J].Eur J Endocrinol Eur Fed Endocr Soc,2002,147:173-180.
[6]Oberbach A,T?njes A.Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance[J].Eur J Endocrinol Eur Fed Endocr Soc,2006,154:577-585.
[7]Akbarpour M.The effect of aerobic training on serum adiponectin and leptin levels and inflammatory markers of coronary heart disease in obese men[J].Biol Sport,2013,30:21-27.
[8]Izadi M,Goodarzi MT.Relationship of serum adiponectin and beta-cell function in obese males with type 2 diabetes[J].Asian J Pharm Biol Res,2012,2:40-44.
[9]Izadi M,Goodarzi MT.Serum adiponectin levels are inversely correlated with insulin resistance in obese men with type 2 diabetes[J].Int J Endocrinol Metab,2011,9:253-257.
[10]Yamauchi T,Kamon J,Waki H,et al.The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity[J].Nat Med,2001,7:941-946.
[11]Lafontan M,Viguerie N.Role of adipokines in the control of energy metabolism:focus on adiponectin[J].Curr Opin Pharmacol,2006,6:580-585.
[12]Yoon MJ,Lee GY,Chang JJ,et a1.Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase,p38 mitogenactivated protein kinase,and peroxisome proliferator–activated receptorα[J].Diabetes,2006,55:2562-2570.
[13]kamoto Y,Kihara S,Funahashi T,et a1 Adiponectin:a key adipocytokine in metabolic syndrome[J].Clin Sci,2006,110:267.
[14]Ouchi N,Kihara S,Funashashi T,et al.Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.Circulation,2003,107:671-674.
[15]Xu A,Vanhoutte PM.Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease[J].Am J Physiol Heart Circ Physiol,2012,302:1231-1240.
[16]Lovren F,Pan Y,Quan A,et al.Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages[J].Am J Physiol Heart Circ Physiol,2010,299:656-663.
[17]Li H,F?rstermann U.Nitric oxide in the pathogenesis of vascular disease[J].J Pathol,2000,190:244-254.
[18]Ouchi N,Walsh K.Adiponectin as an antiinflammatory factor[J].Clin Chim Acta,2007,380:24–30.
[19]Szmitko PE,Wang CH,Weisel RD,et a1.New markers of inflammation and endothelial cell activation part I[J].Circulation,2003,108:1917–1923.
[20]Chen SJ,Yen CH,Huang YC,et a1.Relationships between inflammation,adiponectin,and oxidative stress in metabolic syn-drome[J].PLo S One,2012,7:e45693.
[21]Furukawa S,Fujita T,Shimabukuro M,et al.Increased oxidative stress in obesity and its impact on metabolic syndrome[J].J Clin Invest,2004,114:1752-1761.
[22]He QR,Yu T,Li P.Association of oxidative stress and serum adiponectin in patients with metabolic syndrome[J].Sichuan Da Xue Xue Bao Yi Xue Ban,2009,40:623-627.
[23]Jacobsen DW.Hyperhomocysteinemia and oxidative stress time for a reality check?[J].Arterioscler Thromb Vasc Biol,2000,20:1182-1184.
[24]Alexander J K,Alister Pw Funnell1,et al.Adipokines and insulin action-A sensitive issue[J].Landes Bioscience,2014,3:88–96.
[25]Bruun JM,Lihn AS,Verdich C,et a1.Regulation of adiponectin by adipose tissue-derived cytokines:in vivo and in vitro investigations in humans[J].Am J Physiol Endocrinol Metab,2003,285:527-533.
[26]Wijesekara N,Krishnamurthy M,Bhattacharjee A,et a1.Adiponectininduced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion[J].J Biol Chem,2010,285:33623-33631.
[27]Han SH,Quon MJ,Koh KK.Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction[J].Curr Opin Lipidol,2007,18:58-65.
[28]Kumada M,Kihara S,Koh KK,et al.Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages[J].Circulation,2004,109:2046-2049.