DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

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英文篇名：DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells 作者：Wenting ; Xue ; Zhenghan ; Di ; Ya ; Zhao ; Aiping ; Zhang ; Lele ; Li 英文作者：Wenting Xue;Zhenghan Di;Ya Zhao;Aiping Zhang;Lele Li;College of Pharmacy, Shanxi Medical University;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology;University of Chinese Academy of Sciences; 英文关键词：Bioimaging;;Upconversion nanoparticles;;Self-assembly;;Quantum dots;;Cancer targeting 中文刊名：FXKB 英文刊名：中国化学快报(英文版) 机构：College of Pharmacy, Shanxi Medical University;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology;University of Chinese Academy of Sciences; 出版日期：2019-04-15 出版单位：Chinese Chemical Letters 年：2019 期：v.30 基金：supported financially by the National Natural Science Foundation of China (Nos. 21822401, 21771044);; the Young Thousand Talented Program 语种：英文; 页：FXKB201904015 页数：4 CN：04 ISSN：11-2710/O6 分类号：101-104

摘要

superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests.
        superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests.

引文

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