AQP1和AQP4在中枢神经系统疾病中研究进展
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摘要
水通道蛋白(AQPs)是一跨膜蛋白家族,由6次跨膜的单肽链组成,主要调节体内水的转运。在中枢神经系统已经发现9种水通道蛋白,即AQP1、AQP3、AQP4、AQP5、AQP6、AQP7、AQP8、AQP9、AQP11。其中AQP1和AQP4是中枢神经系统中两种最主要的水通道蛋白。近年来,AQP1和AQP4日益受到重视,目前其被认为是多种疾病的特异标记物,其含量的变化可影响某些中枢神经系统疾病的发生发展。通过深入研究AQP1和AQP4在中枢神经系统疾病中的变化,有助于阐明疾病的发病机制,为中枢神经系统疾病的诊断和治疗提供新的思路和方法。
Aquaporins(AQPs), a member of transmembrane protein family, are composed of six membrane-spanning monopeptide chains, which mainly mediate water flux in the body. Nine AQPs have been identified in the central nervous system: AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, AQP11. AQP1 and AQP4 are two of the most important water-channel proteins in the central nervous system. Recently, AQP1 and AQP4 are increasingly valued and now considered a specific marker for a variety of diseases. Changes in their content can affect the development of certain CNS diseases. Further study on the changes of AQP1 and AQP4 in CNS diseases will help to clarify the pathogenesis of CNS diseases and provide new ideas and methods for diagnosis and treatment of CNS diseases.
Aquaporins(AQPs), a member of transmembrane protein family, are composed of six membrane-spanning monopeptide chains, which mainly mediate water flux in the body. Nine AQPs have been identified in the central nervous system: AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, AQP11. AQP1 and AQP4 are two of the most important water-channel proteins in the central nervous system. Recently, AQP1 and AQP4 are increasingly valued and now considered a specific marker for a variety of diseases. Changes in their content can affect the development of certain CNS diseases. Further study on the changes of AQP1 and AQP4 in CNS diseases will help to clarify the pathogenesis of CNS diseases and provide new ideas and methods for diagnosis and treatment of CNS diseases.
引文
[1]Xu M,Xiao M,Li S,et al.Aquaporins in nervous system[J].Adv Exp Med Biol,2017,969:81-103.
[2]Tani K,Fujiyoshi Y.Water channel structures analysed by electron crystallography[J].Biochim Biophys Acta,2014,1840(5):1605-1613.
[3]Arciénega II,Brunet JF,Bloch J,et al.Cell locations for AQP1,AQP4 and 9 in the non-human primate brain[J].Neuroscience,2014,167(4):1103-1114.
[4]Yang B,Brown D,Verkman AS.The mercurial insensitive water channel(AQP-4)forms orthogonal arrays in stably transfected Chinese hamster ovary cells[J].J Biol Chem,1996,271(9):4577-4580.
[5]Hubbard JA,Hsu MS,Seldin MM,et al.Expression of the astrocyte water channel aquaporin-4 in the mouse brain[J].Asn Neuro,2015,7(5):1-14.
[6]Badaut J,Fukuda AM,Jullienne A,et al.Aquaporin and brain diseases[J].Biochim Biophys Acta,2014,1840(5):1554-1565.
[7]Kim JH,Lee YW,Park KA,et al.Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia[J].J Cereb Blood Flow Metab,2010,30(5):943-949.
[8]Akdemir G,Kaymaz F,Gursoy-?zdemir Y,et al.The time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat[J].Surg Neurol Int,2016,7:4.
[9]Hirt L,Ternon B,Price M,et al.Protective role of early aquaporin 4induction against postischemic edema formation[J].J Cereb Blood Flow Metab,2009,29(2):423-433.
[10]Friedman B,Schachtrup C,Tsai PS,et al.Acute vascular disruption and aquaporin 4 loss after stroke[J].Stroke,2009,40(6):2182-2190.
[11]Fukuda AM,Pop V,Spagnoli D,et al.Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury:possible role in edema resolution?[J].Neuroscience,2012,222:366-378.
[12]Higashida T,Kreipke CW,Rafols JA,et al.The role of hypoxia-inducible factor-1alpha,aquaporin-4,and matrix metalloproteinase-9in blood-brain barrier disruption and brain edema after traumatic brain injury[J].J Neurosurg,2011,114(1):92-101.
[13]Tomura S,Nawashiro H,Otani N,et al.Effect of decompressive cra-niectomy on aquaporin-4 expression after lateral fluid percussion injury in rats[J].J Neurotrauma,2011,28(2):237-243.
[14]Papadopoulos MC,Manley GT,Krishna S,et al.Aquaporin-4 facilitates re-absorption of excess fluid in vasogenic brain edema[J].FASEB J,2004,18(11):1291-1293.
[15]Tourdias T,Mori N,Dragonu I,et al.Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation[J].J Neuroinflammation,2011,8:143.
[16]Madany M,Thomas TM,Edwards L,et al.Immunobiology and immunotherapeutic targeting of glioma stem cells[J].Adv Exp Med Biol,2015,853:139-166.
[17]El Hindy N,Bankfalvi A,Herring A,et al.Correlation of aquaporin-1water channel protein expression with tumor angiogenesis in human astrocytoma[J].Anticancer Res,2013,33(2):609-613.
[18]El Hindy N,Rump K,Lambertz N,et al.The functional Aquaporin1-783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme[J].J Surg Oncol,2013,108(7):492-498.
[19]Liao ZQ,Ye M,Yu PG,et al.Glioma-Associated Oncogene Homolog1(Gli1)-Aquaporin1 pathway promotes glioma cell metastasis[J].BMB Rep,2016,49(7):394-399.
[20]Suero Molina EJ,Ardon H,Schroeteler J,et al.Aquaporin-4 in glioma and metastatic tissues harboring 5-aminolevulinic acid-induced porphyrin fluorescence[J].Clin Neurol Neurosurg,2013,115(10):2075-2081.
[21]Chen Y,Gao F,Jiang R,et al.Down-regulation of AQP4 expression via p38 MAPK signaling in temozolomide-induced glioma cells growth inhibition and invasion impairment[J].J Cell Biochem,2017,118(12):4905-4913.
[22]Lan YL,Zou S,Chen JJ,et al.The neuroprotective effect of the association of aquaporin-4/glutamate transporter-1 against Alzheimer's Disease[J].Neural Plast,2016,2016:4626593.
[23]Iliff JJ,Lee H,Yu M,et al.Brain-wide pathway for waste clearance captured by contrast-enhanced MRI[J].J Clin Invest,2013,123(3):1299-1309.
[24]Iliff JJ,Chen MJ,Plog BA,et al.Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury[J].J Neurosci,2014,34(49):16180-16193.
[25]Xu Z,Xiao N,Chen Y,et al.Deletion of aquaporin-4 in APP/PS1mice exacerbates brain Abeta accumulation and memory deficits[J].Mol Neurodegener,2015,10:58.
[26]Zeppenfeld DM,Simon M,Haswell JD,et al.Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains[J].JAMA Neurol,2017,74(1):91-99.
[27]Burfeind KG,Murchison CF,Westaway SK,et al.The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease[J].Alzheimers Dement(N Y),2017,3(3):348-359.
[28]Misawa T,Arima K,Mizusawa H,et al.Close association of water channel AQP1 with amyloid-βdeposition in Alzheimer disease brains[J].Acta Neuropathol,2008,116(3):247-260.
[29]Hoshi A,Yamamoto T,Shimizu K,et al.Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer Disease[J].J Neuropathol Exp Neurol,2012,71(8):750-759.
[30]Hirsch EC,Jenner P,Przedborski S.Pathogenesis of Parkinson's Disease[J].Mov Disord,2013,28(1):24-30.
[31]Fan Y,Kong H,Shi X,et al.Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation[J].Neurobiol Aging,2007,29(8):1226-1236.
[32]Zhang J,Yang B,Sun H,et al.Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in ex-perimental Parkinson's disease[J].Neurosci Lett,2016,614:7-15.
[33]Sun H,Liang R,Yang B.Aquaporin-4 mediates communication between astrocyte and microglia:Implications of neuroinflammation in experimental Parkinson's disease[J].Neuroscience,2016,317:65-75.
[34]Ofori E,Pasternak O,Planetta PJ,et al.Increased free water in the substantia nigra of Parkinson's disease:a single-site and multi-site study[J].Neurobiology Aging,2014,36(2):1097-1104.
[35]Ofori E,Pasternak O,Planetta PJ,et al.Longitudinal changes in free-water within the substantia nigra of Parkinson's disease[J].Brain,2015,138(Pt 8):2322-2331.
[36]Prydz A,Stahl K,Puchades M,et al.Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice[J].Neuroscience,2017,359:258-266.
[37]Uzawa A,Mori M,Kuwabara S.Neuromyelitis optica:concept,immunology and treatment[J].J Clin Neurosci,2014,21(1):12-21.
[38]Jarius S,Wildemann B.‘Noteomielite’accompanied by acute amaurosis(1844):an early case of neuromyelitis optica[J].J Neurol Sci,2012,313(1-2):182-184.
[39]Jarius S,Wildemann B.The case of the Marquis de Causan(1804):an early account of visual loss associated with spinal cord inflammation[J].J Neurol Sci,2012,259(7):1354-1357.
[40]Jarius S,Wildemann B.An early case of neuromyelitis optica:on aforgotten report by Jacob Lockhart Clarke,FRS[J].Mult Scler,2011,17(11):1384-1386.
[41]Lennon VA,Wingerchuk DM,Kryzer TJ,et al.A serum utoantibody marker of neuromyelitis optica:distinction from multiple sclerosis[J].Lancet,2004,364(9451):2106-2112.
[42]Lennon VA,Kryzer TJ,Pittock SJ,et al.Ig G marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel[J].J Exp Med,2005,202(4):473-477.
[43]Hinson SR,Pittock SJ,Lucchinetti CF,et al.Pathogenic potential of Ig G binding to water channel extracellular domain in neuromyelitis optica[J].Neurology,2007,69(24):2221-2231.
[44]Ratelade J,Zhang H,Saadoun S,et al.Neuromyelitis optica Ig G and natural killer cells produce NMO lesions in mice without myelin loss[J].Acta Neuropathol,2012,123(6):861-872.
[45]Saadoun S,Waters P,Bell BA,et al.Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice[J].Brain,2010,133(Pt2):349-361.
[46]Chihara N,Aranami T,Sato W,et al.Interleukin 6 signaling promotes antiaquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica[J].Proc Natl Acad Sci USA,2011,108(9):3701-3706.
[2]Tani K,Fujiyoshi Y.Water channel structures analysed by electron crystallography[J].Biochim Biophys Acta,2014,1840(5):1605-1613.
[3]Arciénega II,Brunet JF,Bloch J,et al.Cell locations for AQP1,AQP4 and 9 in the non-human primate brain[J].Neuroscience,2014,167(4):1103-1114.
[4]Yang B,Brown D,Verkman AS.The mercurial insensitive water channel(AQP-4)forms orthogonal arrays in stably transfected Chinese hamster ovary cells[J].J Biol Chem,1996,271(9):4577-4580.
[5]Hubbard JA,Hsu MS,Seldin MM,et al.Expression of the astrocyte water channel aquaporin-4 in the mouse brain[J].Asn Neuro,2015,7(5):1-14.
[6]Badaut J,Fukuda AM,Jullienne A,et al.Aquaporin and brain diseases[J].Biochim Biophys Acta,2014,1840(5):1554-1565.
[7]Kim JH,Lee YW,Park KA,et al.Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia[J].J Cereb Blood Flow Metab,2010,30(5):943-949.
[8]Akdemir G,Kaymaz F,Gursoy-?zdemir Y,et al.The time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat[J].Surg Neurol Int,2016,7:4.
[9]Hirt L,Ternon B,Price M,et al.Protective role of early aquaporin 4induction against postischemic edema formation[J].J Cereb Blood Flow Metab,2009,29(2):423-433.
[10]Friedman B,Schachtrup C,Tsai PS,et al.Acute vascular disruption and aquaporin 4 loss after stroke[J].Stroke,2009,40(6):2182-2190.
[11]Fukuda AM,Pop V,Spagnoli D,et al.Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury:possible role in edema resolution?[J].Neuroscience,2012,222:366-378.
[12]Higashida T,Kreipke CW,Rafols JA,et al.The role of hypoxia-inducible factor-1alpha,aquaporin-4,and matrix metalloproteinase-9in blood-brain barrier disruption and brain edema after traumatic brain injury[J].J Neurosurg,2011,114(1):92-101.
[13]Tomura S,Nawashiro H,Otani N,et al.Effect of decompressive cra-niectomy on aquaporin-4 expression after lateral fluid percussion injury in rats[J].J Neurotrauma,2011,28(2):237-243.
[14]Papadopoulos MC,Manley GT,Krishna S,et al.Aquaporin-4 facilitates re-absorption of excess fluid in vasogenic brain edema[J].FASEB J,2004,18(11):1291-1293.
[15]Tourdias T,Mori N,Dragonu I,et al.Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation[J].J Neuroinflammation,2011,8:143.
[16]Madany M,Thomas TM,Edwards L,et al.Immunobiology and immunotherapeutic targeting of glioma stem cells[J].Adv Exp Med Biol,2015,853:139-166.
[17]El Hindy N,Bankfalvi A,Herring A,et al.Correlation of aquaporin-1water channel protein expression with tumor angiogenesis in human astrocytoma[J].Anticancer Res,2013,33(2):609-613.
[18]El Hindy N,Rump K,Lambertz N,et al.The functional Aquaporin1-783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme[J].J Surg Oncol,2013,108(7):492-498.
[19]Liao ZQ,Ye M,Yu PG,et al.Glioma-Associated Oncogene Homolog1(Gli1)-Aquaporin1 pathway promotes glioma cell metastasis[J].BMB Rep,2016,49(7):394-399.
[20]Suero Molina EJ,Ardon H,Schroeteler J,et al.Aquaporin-4 in glioma and metastatic tissues harboring 5-aminolevulinic acid-induced porphyrin fluorescence[J].Clin Neurol Neurosurg,2013,115(10):2075-2081.
[21]Chen Y,Gao F,Jiang R,et al.Down-regulation of AQP4 expression via p38 MAPK signaling in temozolomide-induced glioma cells growth inhibition and invasion impairment[J].J Cell Biochem,2017,118(12):4905-4913.
[22]Lan YL,Zou S,Chen JJ,et al.The neuroprotective effect of the association of aquaporin-4/glutamate transporter-1 against Alzheimer's Disease[J].Neural Plast,2016,2016:4626593.
[23]Iliff JJ,Lee H,Yu M,et al.Brain-wide pathway for waste clearance captured by contrast-enhanced MRI[J].J Clin Invest,2013,123(3):1299-1309.
[24]Iliff JJ,Chen MJ,Plog BA,et al.Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury[J].J Neurosci,2014,34(49):16180-16193.
[25]Xu Z,Xiao N,Chen Y,et al.Deletion of aquaporin-4 in APP/PS1mice exacerbates brain Abeta accumulation and memory deficits[J].Mol Neurodegener,2015,10:58.
[26]Zeppenfeld DM,Simon M,Haswell JD,et al.Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains[J].JAMA Neurol,2017,74(1):91-99.
[27]Burfeind KG,Murchison CF,Westaway SK,et al.The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease[J].Alzheimers Dement(N Y),2017,3(3):348-359.
[28]Misawa T,Arima K,Mizusawa H,et al.Close association of water channel AQP1 with amyloid-βdeposition in Alzheimer disease brains[J].Acta Neuropathol,2008,116(3):247-260.
[29]Hoshi A,Yamamoto T,Shimizu K,et al.Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer Disease[J].J Neuropathol Exp Neurol,2012,71(8):750-759.
[30]Hirsch EC,Jenner P,Przedborski S.Pathogenesis of Parkinson's Disease[J].Mov Disord,2013,28(1):24-30.
[31]Fan Y,Kong H,Shi X,et al.Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation[J].Neurobiol Aging,2007,29(8):1226-1236.
[32]Zhang J,Yang B,Sun H,et al.Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in ex-perimental Parkinson's disease[J].Neurosci Lett,2016,614:7-15.
[33]Sun H,Liang R,Yang B.Aquaporin-4 mediates communication between astrocyte and microglia:Implications of neuroinflammation in experimental Parkinson's disease[J].Neuroscience,2016,317:65-75.
[34]Ofori E,Pasternak O,Planetta PJ,et al.Increased free water in the substantia nigra of Parkinson's disease:a single-site and multi-site study[J].Neurobiology Aging,2014,36(2):1097-1104.
[35]Ofori E,Pasternak O,Planetta PJ,et al.Longitudinal changes in free-water within the substantia nigra of Parkinson's disease[J].Brain,2015,138(Pt 8):2322-2331.
[36]Prydz A,Stahl K,Puchades M,et al.Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice[J].Neuroscience,2017,359:258-266.
[37]Uzawa A,Mori M,Kuwabara S.Neuromyelitis optica:concept,immunology and treatment[J].J Clin Neurosci,2014,21(1):12-21.
[38]Jarius S,Wildemann B.‘Noteomielite’accompanied by acute amaurosis(1844):an early case of neuromyelitis optica[J].J Neurol Sci,2012,313(1-2):182-184.
[39]Jarius S,Wildemann B.The case of the Marquis de Causan(1804):an early account of visual loss associated with spinal cord inflammation[J].J Neurol Sci,2012,259(7):1354-1357.
[40]Jarius S,Wildemann B.An early case of neuromyelitis optica:on aforgotten report by Jacob Lockhart Clarke,FRS[J].Mult Scler,2011,17(11):1384-1386.
[41]Lennon VA,Wingerchuk DM,Kryzer TJ,et al.A serum utoantibody marker of neuromyelitis optica:distinction from multiple sclerosis[J].Lancet,2004,364(9451):2106-2112.
[42]Lennon VA,Kryzer TJ,Pittock SJ,et al.Ig G marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel[J].J Exp Med,2005,202(4):473-477.
[43]Hinson SR,Pittock SJ,Lucchinetti CF,et al.Pathogenic potential of Ig G binding to water channel extracellular domain in neuromyelitis optica[J].Neurology,2007,69(24):2221-2231.
[44]Ratelade J,Zhang H,Saadoun S,et al.Neuromyelitis optica Ig G and natural killer cells produce NMO lesions in mice without myelin loss[J].Acta Neuropathol,2012,123(6):861-872.
[45]Saadoun S,Waters P,Bell BA,et al.Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice[J].Brain,2010,133(Pt2):349-361.
[46]Chihara N,Aranami T,Sato W,et al.Interleukin 6 signaling promotes antiaquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica[J].Proc Natl Acad Sci USA,2011,108(9):3701-3706.