Toll样受体2基因Arg753Gln和CD14启动子-159C/T多态性与肺炎链球菌病易感性的Meta分析
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摘要
目的评价Toll样受体2基因Arg753Gln和CD14启动子-159C/T多态性与肺炎链球菌病易感性的相关性。方法检索PubMed、Cohrance、Embase、CNKI、维普、万方等数据平台,检索文献时间限定为从建库到2017年6月1日。搜寻符合纳入和排除条件的随机对照研究,RevMan 5.3软件进行Meta分析。结果纳入TLR2有关论文3篇,样本量总计为951例;纳入CD14相关研究2篇,样本量总计为674例。Meta分析未见TLR2基因Arg753Gln多态性和CD14-159C/T多态性与肺炎链球菌病易感性相关(显性等位基因vs.隐性等位基因:OR=0.76,95%CI=0.40～1.46,P=0.41;显性基因型vs.隐性基因型时,OR=0.70,95%CI=0.34～1.44,P=0.33)。结论未见TLR2基因Arg753Gln和CD14-159C/T多态性与肺炎链球菌病易感性相关。
Objective To investigate the association between TLR2 Arg753 Gln and CD14-159 C/T polymorphisms and Streptococcus pneumoniae disease. Methods Pubmed, embase, Cohrance, CNKI, VIP, Wanfang Data were searched to get related clinical controlled trials. The time limit for retrieving studies was until June 1, 2017. Meta-analysis was conducted by Revman 5.3 software. Results Three TLR2 related papers were included, with a total sample size of 951 cases. Two CD14 related studies were included, with a total sample size of 674 cases. Meta-analysis showed no correlation between Arg753 Gln polymorphism of TLR2 gene and CD14-159 C/T polymorphism and susceptibility to Streptococcus pneumoniae disease(dominant allele vs. recessive alleles: OR=0.76, 95%CI=0.40-1.46, P=0.41; dominant genotype vs. recessive genotype: OR =0.70, 95% CI =0.34-1.44, P =0.33). Conclusion No significant differences between TLR2 Arg753 Gln and CD14-159 C/T polymorphisms and Streptococcus pneumoniae disease were found in the meta-analysis.
Objective To investigate the association between TLR2 Arg753 Gln and CD14-159 C/T polymorphisms and Streptococcus pneumoniae disease. Methods Pubmed, embase, Cohrance, CNKI, VIP, Wanfang Data were searched to get related clinical controlled trials. The time limit for retrieving studies was until June 1, 2017. Meta-analysis was conducted by Revman 5.3 software. Results Three TLR2 related papers were included, with a total sample size of 951 cases. Two CD14 related studies were included, with a total sample size of 674 cases. Meta-analysis showed no correlation between Arg753 Gln polymorphism of TLR2 gene and CD14-159 C/T polymorphism and susceptibility to Streptococcus pneumoniae disease(dominant allele vs. recessive alleles: OR=0.76, 95%CI=0.40-1.46, P=0.41; dominant genotype vs. recessive genotype: OR =0.70, 95% CI =0.34-1.44, P =0.33). Conclusion No significant differences between TLR2 Arg753 Gln and CD14-159 C/T polymorphisms and Streptococcus pneumoniae disease were found in the meta-analysis.
引文
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[15]Guo T,Cai J,Peng Y,et al.Protective effect of an antibody against specific extracellular domain of TLR2 on agonistsdriven inflammatory and allergic response[J].Biomed Res Int,2016,(2016):1-8.
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[17]王耀辉,高丽丽,刘春样,等.溃疡性结肠炎患者Toll样受体2和转化生长因子-β水平变化及意义[J].中华实用诊断与治疗杂志,2017,31(1):51-53.
[18]Zeljic K,Supic G,Jovic N,et al.Association of TLR2,TLR3,TLR4 and CD14 genes polymorphisms with oral cancer risk and survival[J].Oral Dis,2014,20(4):416-424.
[19]Thorburn AN,Tseng HY,Donovan C,et al.TLR2,TLR4 and MyD88 mediate allergic airway disease(AAD)and Streptococcus pneumoniae-Induced suppression of AAD[J].PLoS One,2016,11(6):e0156402.
[20]H Zhang,L Kang,H Yao,et al.Streptococcus pneumoniae Endopeptidase O(PepO)Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 signaling pathways[J].Front Cell Infet Mi,2016,6:23.
[2]Nilsen NJ,Vladimer GI,Stenvik J.A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling[J].J Biol Chem,2015,290(6):3209-3222.
[3]Du B,Luo W,Li R,et al.Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression[J].J Biol Chem,2013,288(21):15 131-15 141.
[4]王红,杜娟,董亚琼.成人重症肺炎107例病原学分析[J].贵州医药,2015,39(4):358-358.
[5]Iroh Tam PY,Thielen BK,Obaro SK,et al.Childhood pneumococcal disease in Africa-A systematic review and metaanalysis of incidence,serotype distribution,and antimicrobial susceptibility[J].Vaccine,2017,35(15):1817-1827.
[6]Moens L,Verhaegen J,Pierik M,et al.Toll-like receptor 2and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease[J].Microbes Infect,2007,9(1):15-20.
[7]Yuan FF,Marks K,Wong M,et al.Clinical relevance of TLR2,TLR4,CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection[J].Immunol Cell Biol,2008,86(3):268-270.
[8]Tellería-Orriols JJ,García-Salido A,Varillas D,et al.TLR2-TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae[J].Med Intensiva,2014,38(6):356-362.
[9]Atkins D,Best D,Briss PA,et al.Grading quality of evidence and strength of recommendations[J].BMJ,2004,328(7454):1490-1494.
[10]Corsini B,Aguinagalde L,Ruiz S,et al.Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis[J].Vaccine,2016,34(50):6148-6157.
[11]Jaiswal N,Singh M,Thumburu KK,et al.Burden of invasive pneumococcal disease in children aged 1 month to 12years living in South Asia:a systematic review[J].PLoS One,2014,9(5):e96282.
[12]Musie E,Moore CC,Martin EN,et al.Toll-like receptor 4stimulation before or after Streptococcus pneumoniae induced sepsis improves survival and is dependent on Tcells[J].PLoS One,2014,9(1):e86015.
[13]Tomlinson G,Chimalapati S,Pollard T,et al.TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins[J].J Immunol,2014,193(7):3736-3745.
[14]Du B,Luo W,Li R,et al.Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression[J].J Biol Chem,2013,288(21):15 131-15 141.
[15]Guo T,Cai J,Peng Y,et al.Protective effect of an antibody against specific extracellular domain of TLR2 on agonistsdriven inflammatory and allergic response[J].Biomed Res Int,2016,(2016):1-8.
[16]Gao D,Li W.Structures and recognition modes of toll-like receptors[J].Proteins,2017,85(1):3-9.
[17]王耀辉,高丽丽,刘春样,等.溃疡性结肠炎患者Toll样受体2和转化生长因子-β水平变化及意义[J].中华实用诊断与治疗杂志,2017,31(1):51-53.
[18]Zeljic K,Supic G,Jovic N,et al.Association of TLR2,TLR3,TLR4 and CD14 genes polymorphisms with oral cancer risk and survival[J].Oral Dis,2014,20(4):416-424.
[19]Thorburn AN,Tseng HY,Donovan C,et al.TLR2,TLR4 and MyD88 mediate allergic airway disease(AAD)and Streptococcus pneumoniae-Induced suppression of AAD[J].PLoS One,2016,11(6):e0156402.
[20]H Zhang,L Kang,H Yao,et al.Streptococcus pneumoniae Endopeptidase O(PepO)Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 signaling pathways[J].Front Cell Infet Mi,2016,6:23.