ATBF 1基因在恶性肿瘤中的研究进展
|
摘要
AT模序结合因子1(AT-motif binding factor 1,ATBF1)又名为锌指同源框3(zincnger homeobox 3,ZFHX3),通过与启动子中的AT富含原件结合调控基因转录,是目前发现的相对分子质量最大的转录调节因子。近年来,越来越多的研究表明,ATBF1基因是一个重要的候选抑癌基因。ATBF 1基因在前列腺癌、胃癌、乳腺癌、宫颈癌和结直肠癌等多种恶性肿瘤中频繁发生基因缺失和突变、表达下调和蛋白定位异位等,通过多种信号途径参与细胞生命活动,影响细胞增殖、分化和凋亡,调控肿瘤的发生和发展。本文依次从DNA水平、mRNA水平、蛋白水平和分子机制4个方面对ATBF1基因在肿瘤中的研究进展进行综述,以期更全面综合地了解ATBF 1基因的抑癌机制及其对肿瘤诊断治疗的临床意义。
AT-motif binding factor 1(ATBF1), also named as zinc finger homeobox 3(ZFHX3), is reported as a transcriptional regulator with the highest molecular weight. ATBF1 regulates mRNA transcription by binding to AT-rich motif of gene promoter. In recent years, more and more studies have shown that ATBF1 gene is an important candidate tumor suppressor gene. Frequent mutations and loss of heterozygosity(LOH) are found in ATBF1 gene in multiple tumors, including prostate cancer, gastric cancer, breast cancer, cervical cancer and colorectal cancer. The gene expression and protein localization of ATBF1 are associated with the clinical diagnosis and treatment of tumors. Moreover, ATBF1 plays an essential role in multiple signaling pathways to regulate cell proliferation, differentiation and apoptosis. This review summarizes the research progress of ATBF 1 gene in malignant tumors from four aspects: DNA, mRNA, protein and molecular mechanism, in order to comprehesively understand the anti-cancer mechanism of ATBF1 and its clinical significance in diagnosis and treatment of tumors.
AT-motif binding factor 1(ATBF1), also named as zinc finger homeobox 3(ZFHX3), is reported as a transcriptional regulator with the highest molecular weight. ATBF1 regulates mRNA transcription by binding to AT-rich motif of gene promoter. In recent years, more and more studies have shown that ATBF1 gene is an important candidate tumor suppressor gene. Frequent mutations and loss of heterozygosity(LOH) are found in ATBF1 gene in multiple tumors, including prostate cancer, gastric cancer, breast cancer, cervical cancer and colorectal cancer. The gene expression and protein localization of ATBF1 are associated with the clinical diagnosis and treatment of tumors. Moreover, ATBF1 plays an essential role in multiple signaling pathways to regulate cell proliferation, differentiation and apoptosis. This review summarizes the research progress of ATBF 1 gene in malignant tumors from four aspects: DNA, mRNA, protein and molecular mechanism, in order to comprehesively understand the anti-cancer mechanism of ATBF1 and its clinical significance in diagnosis and treatment of tumors.
引文
[1] MORINAGA T, YASUDA H, HASHIMOTO T, et al. A human alpha-fetoprotein enhancer-binding protein,ATBF1,contains four homeodomains and seventeen zinc fingers[J]. Mol Cell Biol,1991, 1 1(1 2):6041-6049.
[2]钟林,陈飞,李强,等. ATBF1研究综述[J].现代生物医学进展,2014,14(16):3170-3173.
[3] SUN X, FU X, LI J, et al. Heterozygous deletion of ATBF1 by the Cre-loxP system in mice causes preweaning mortality[J].Genesis, 2012, 50(1 1):819-827.
[4] LI M, FU X, MA G, et al. ATBF1regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogenER signaling[J]. PLoS One, 2012, 7(1 2):e51283.
[5] ZHAO D, MA G, ZHANG X, et al. Zinc finger homeodomain factor ZFHX3is essential for mammary lactogenic differentiation by maintaining prolactin signaling activity[J].J Biol Chem, 201 6, 291(24):1 2809-12820.
[6] ZHANG S, KIM TS, DONG Y, et al.AT motif binding factor 1(ATBF1)is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1[J]. Biochem Biophys Res Commun, 2012, 427(3):537-541.
[7] JUNG CG, UHM KO, MIURA Y, et al.Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons[J]. Mol Neurodegener, 2011,6:47.
[8] JUNG CG, KIM HJ, KAWAGUCHI M, et al.Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation[J]. Development, 2005,132(23):5137-5145.
[9] SUN X, FRIERSON HF, CHEN C, et al.Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer[J]. Nat Genet, 2005,37(4):407-412.
[10] KATAOKA H, MIURA Y, KAWAGUCHI M, et al.Expression and subcellular localization of AT motif binding factor 1 in colon tumours[J]. Mol Med Rep, 2017, 16(3):3095-3102.
[11] MIURA Y, TAM T, IDO A, et al.Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner[J]. J Biol Chem, 1 995,270(45):26840-26848.
[12] ISHII Y, KAWAGUCHI M, TAKAGAWA K, et al. ATBF1-A protein,but not ATBF1-B,is preferentially expressed in developing rat brain[J].J Comp Neurol,2003, 465(1):57-71.
[13] KOMINE Y, TAKAO K, MIYAKAWA T, et al.Behavioral abnormalities observed in ZFHX2-deficient mice[J]. PLoS One,2012, 7(12):e53114.
[14] HEMMI K, MA D, MIURA Y, et al. A homeodomain-zinc finger protein,ZFHX4, is expressed in neuronaldifferentiation manner and suppressed in muscle differentiation manner[J]. Biol Pharm Bull, 2006,29(9):1 830-1 835.
[15] HABIB AM,MATSUYAMA A,OKOROKOV AL, et al. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2[J]. Brain.2018, 141(2):365-376.
[16] UHM KO, KIM MJ, KAWAGUCHI M, et al.ATBF1 is a novel amyloid-beta protein precursor(AbetaPP)binding protein that affects AbetaPP expression[J].J A/zheimers Dis, 2015, 43(1):243-257.
[17] QING T, ZHU S, SUO C, et al. Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients[J]. Sci Rep, 2017,7(1):4951.
[18] CHUDNOVSKY Y, KIM D, ZHENG S,et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state[J]. Cell Rep, 2014, 6(2):313-324.
[19] KAI K, ZHANG Z, YAMASHITA H, et al.Loss of heterozygosity at the ATBF1-A locus located in the 1 6q22 minimal region in breast cancer[J].BMC Cancer,2008, 8:262.
[20] PANACCIONE A, ZHANG Y, MI Y, et al.Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma[J].Oral Oncol, 2017, 66:38.
[21] WALKER CJ, MIRANDA MA, O'HERN MJ,et al. Patterns of CTCF and ZFHX3mutation and associated outcomes in endometrial cancer[J].J Natl Cancer Inst, 2015, 107(11):djv249.
[22] KIM CJ, SONG JH, CHO YG, et al.Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma[J].Histopathology, 2008, 52(5):552-559.
[23] XU J, SAUVAGEOT J, EWING CM, et al.Germline ATBF1 mutations and prostate cancer risk[J]. Prostate, 2006,66(10):1 082-1 085.
[24] KANDOTH C, SCHULTZ N, CHERNIACK AD, et al. Integ rated genomiccharacterization of endometrial carci noma[J]. Nature, 2013,497(7447):67-73.
[25] SUN X, FU X, LI J, et al. Deletion of ATBF1/ZFHX3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways[J]. Neoplasia,2014, 1 6(5):377-389.
[26] SUN X, XING C, FU X, et al. Additive Effect of ZFHX3/ATBF1 and PTEN deletion on mouse prostatic tumorigenesis[J].J Genet Genomics,201 5,42(7):373-382.
[27] MAO L, HUANG W, ZOU P, et al.The unrecognized role of tumor suppressor genes in atrial fibrillation[J]. Gene, 2018, 642:26-31.
[28] OSTENFELD EB, ERICHSEN R, PEDERSEN L, et al. Atrial fibrillation as a marker of occult cancer[J]. PLoS One, 2014, 9(8):e102861.
[29] ERICHSEN R, CHRISTIANSEN CF,MEHNERT F, et al. Colorectal cancer and risk of atrial fibrillation and flutter:a population-based casecontrol study[J]. Intern Emerg Med,2012, 7(5):431-438.
[30] LI C, WANG F, YANG Y, et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GenelD population[J].Hum Genet, 2011, 1 29(3):239-246.
[31] BENJAMIN EJ, RICE KM, ARKING DE, et al.Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry[J]. Nat Genet, 2009,41(8):879-881.
[32] TSAI CT, HSIEH CS, CHANG SN, et al.Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation[J].J Med Genet, 2015,52(1):28-36.
[33] ZHANG Z, YAMASHITA H, TOYAMA T, et al.ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer[J]. Clin Cancer Res,2005, 1 1(1):193-198.
[34] CHO YG, SONG JH, KIM CJ, et al.Genetic alterations of the ATBF] gene in gastric cancer[J]. Clin Cancer Res,2007, 13(15Pt 1):4355-4359.
[35]钟林,陈飞,李强,等.ATBF1在结直肠癌中的表达及其与转移相关性研究[J].昆明医科大学学报,2014, 35(6):37-41.
[36]纪术峰,钟林.结直肠癌中ATBF1基因功能分析[J].南方医科大学学报,2016,36(7):957-963.
[37] SUN X, ZHOU Y, OTTO KB, et al.Infrequent mutation of A TBF1 in human breast cancer[J].J Cancer Res Clin Oncol, 2007, 1 33(2):103-1 05.
[38]林志群,赵大川,陈飞,等.AT模体结合因子1对结直肠癌LOVO细胞增殖侵袭的影响[J].肿瘤防治研究,2016,43(4):267-271.
[39] SUN X, LI J, SICA G, et al. Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma[J]. Head Neck, 2013,35(7):1 007-1 014.
[40] KAWAGUCHI M, HARA N, BILIM V, et al.A diagnostic marker for superficial urothelial bladder carcinoma:lack of nuclear ATBF1(ZFHX3)by immunohistochemistry suggests malignant progression[J]. BMC Cancer,2016, 16(1):805.
[41] NISHIO E, MIURA Y, KAWAGUCHI M, et al.Nuclear translocation of ATBF1 is a potential prognostic marker for skin cancer[J]. Acta Dermatovenerol Croat,2012, 20(4):239-245.
[42] MORI Y, KATAOKA H, MIURA Y, et al.Subcellular localization of ATBF1regulates MUC5AC transcription in gastric cancer[J]. Int J Cancer, 2007,121(2):241-247.
[43] LI M, ZHANG C, ZHONG Y, et al.Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells[J]. Biochem Biophys Res Commun, 2017, 490(2):492-498.
[44] SUN X, LI J, DONG FN, et al.Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells[J].PLoS One, 2014, 9(3):e92746.
[45] MABUCHI M, KATAOKA H, MIURA Y,et al. Tumor suppressor, AT motif binding factor 1(ATBF1), translocates to the nucleus with runt domain transcription factor 3(RUNX3)in response to TGF-beta signal transduction[J]. Biochem Biophys Res Commun, 2010, 398(2):321-325.
[46] SAKATA N, KANEKO S, IKENO S,et al. TGF-βsignaling cooperates with AT motif-binding factor-1for repression of theα-fetoprotein promoter[J].J Signal Transduct, 2014,2014:970346.
[47] DONG XY, GUO P, SUN X, et al.Estrogen up-regulates ATBF1transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells[J]. J Biol Chem, 201 1,286(16):1 3879-1 3890.
[48] DONG XY, FU X, FAN S, et al.Oestrogen causes ATBF1 protein degradation through the oestrogenresponsive E3 ubiquitin ligase EFP[J].Biochem J, 2012, 444(3):581-590.
[49] DONG XY, SUN X, GUO P, et al.ATBF1 inhibits estrogen receptor(ER)function by selectively competing with AIB1 for binding to the ER in ERpositive breast cancer cells[J].J Biol Chem, 2010, 285(43):32801-32809.
[50] LI M, ZHAO D, MA G, et al.Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells[J]. Biochem Biophys Res Commun, 2013, 430(1):358-363.
[51] KASPAR P, DVORAKOVA M, KRALOVA J,et al. Myb-interacting protein, ATBF1,represses transcriptional activity of Myb oncoprotein[J].J Biol Chem, 1999,274(20):14422-14428.
[52]张荣贵,余永胜,臧国庆.c-myb及其在肝脏的表达和意义[J].肝脏,2007,12(3):212-214.
[53] NOJIRI S, JOH T, MIURA Y, et al. ATBF1enhances the suppression of STAT3signaling by interaction with PIAS3[J].Biochem Biophys Res Commun, 2004,314(1):97-103.
[54] GALOCZOVA M, COATES P, VOJTESEK B. STAT3, stem cells, cancer stem cells and p63[J]. Cell Mol Biol Lett, 2018,23:12.
[55] JOHNSON DE, O'KEEFE RA, GRANDIS JR.Targeting the IL-6/JAK/STAT3signalling axis in cancer[J]. Nat Rev Clin Oncol, 201 8, 1 5(4):234-248.
[56] ZHANG L, LI J, WANG Q, et al. The relationship between microRNAs and the STAT3-related signaling pathway in cancer[J]. Tumour Biol, 2017,39(7):101042831 7719869.
[57] JIANG Q, NI B, SHI J, et al. Downregulation of ATBF1 activates STAT3signaling via PIAS3 in pacinginduced HL-1 atrial myocytes[J].Biochem Biophys Res Commun, 2014,449(3):278-283.
[58] YANG XH, TANG F, SHIN J, et al.Incorporating genomic, transcriptomic and clinical data:a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma[J]. BMC Syst Biol, 2017, 11(Suppl 5):92.
[2]钟林,陈飞,李强,等. ATBF1研究综述[J].现代生物医学进展,2014,14(16):3170-3173.
[3] SUN X, FU X, LI J, et al. Heterozygous deletion of ATBF1 by the Cre-loxP system in mice causes preweaning mortality[J].Genesis, 2012, 50(1 1):819-827.
[4] LI M, FU X, MA G, et al. ATBF1regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogenER signaling[J]. PLoS One, 2012, 7(1 2):e51283.
[5] ZHAO D, MA G, ZHANG X, et al. Zinc finger homeodomain factor ZFHX3is essential for mammary lactogenic differentiation by maintaining prolactin signaling activity[J].J Biol Chem, 201 6, 291(24):1 2809-12820.
[6] ZHANG S, KIM TS, DONG Y, et al.AT motif binding factor 1(ATBF1)is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1[J]. Biochem Biophys Res Commun, 2012, 427(3):537-541.
[7] JUNG CG, UHM KO, MIURA Y, et al.Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons[J]. Mol Neurodegener, 2011,6:47.
[8] JUNG CG, KIM HJ, KAWAGUCHI M, et al.Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation[J]. Development, 2005,132(23):5137-5145.
[9] SUN X, FRIERSON HF, CHEN C, et al.Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer[J]. Nat Genet, 2005,37(4):407-412.
[10] KATAOKA H, MIURA Y, KAWAGUCHI M, et al.Expression and subcellular localization of AT motif binding factor 1 in colon tumours[J]. Mol Med Rep, 2017, 16(3):3095-3102.
[11] MIURA Y, TAM T, IDO A, et al.Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner[J]. J Biol Chem, 1 995,270(45):26840-26848.
[12] ISHII Y, KAWAGUCHI M, TAKAGAWA K, et al. ATBF1-A protein,but not ATBF1-B,is preferentially expressed in developing rat brain[J].J Comp Neurol,2003, 465(1):57-71.
[13] KOMINE Y, TAKAO K, MIYAKAWA T, et al.Behavioral abnormalities observed in ZFHX2-deficient mice[J]. PLoS One,2012, 7(12):e53114.
[14] HEMMI K, MA D, MIURA Y, et al. A homeodomain-zinc finger protein,ZFHX4, is expressed in neuronaldifferentiation manner and suppressed in muscle differentiation manner[J]. Biol Pharm Bull, 2006,29(9):1 830-1 835.
[15] HABIB AM,MATSUYAMA A,OKOROKOV AL, et al. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2[J]. Brain.2018, 141(2):365-376.
[16] UHM KO, KIM MJ, KAWAGUCHI M, et al.ATBF1 is a novel amyloid-beta protein precursor(AbetaPP)binding protein that affects AbetaPP expression[J].J A/zheimers Dis, 2015, 43(1):243-257.
[17] QING T, ZHU S, SUO C, et al. Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients[J]. Sci Rep, 2017,7(1):4951.
[18] CHUDNOVSKY Y, KIM D, ZHENG S,et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state[J]. Cell Rep, 2014, 6(2):313-324.
[19] KAI K, ZHANG Z, YAMASHITA H, et al.Loss of heterozygosity at the ATBF1-A locus located in the 1 6q22 minimal region in breast cancer[J].BMC Cancer,2008, 8:262.
[20] PANACCIONE A, ZHANG Y, MI Y, et al.Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma[J].Oral Oncol, 2017, 66:38.
[21] WALKER CJ, MIRANDA MA, O'HERN MJ,et al. Patterns of CTCF and ZFHX3mutation and associated outcomes in endometrial cancer[J].J Natl Cancer Inst, 2015, 107(11):djv249.
[22] KIM CJ, SONG JH, CHO YG, et al.Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma[J].Histopathology, 2008, 52(5):552-559.
[23] XU J, SAUVAGEOT J, EWING CM, et al.Germline ATBF1 mutations and prostate cancer risk[J]. Prostate, 2006,66(10):1 082-1 085.
[24] KANDOTH C, SCHULTZ N, CHERNIACK AD, et al. Integ rated genomiccharacterization of endometrial carci noma[J]. Nature, 2013,497(7447):67-73.
[25] SUN X, FU X, LI J, et al. Deletion of ATBF1/ZFHX3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways[J]. Neoplasia,2014, 1 6(5):377-389.
[26] SUN X, XING C, FU X, et al. Additive Effect of ZFHX3/ATBF1 and PTEN deletion on mouse prostatic tumorigenesis[J].J Genet Genomics,201 5,42(7):373-382.
[27] MAO L, HUANG W, ZOU P, et al.The unrecognized role of tumor suppressor genes in atrial fibrillation[J]. Gene, 2018, 642:26-31.
[28] OSTENFELD EB, ERICHSEN R, PEDERSEN L, et al. Atrial fibrillation as a marker of occult cancer[J]. PLoS One, 2014, 9(8):e102861.
[29] ERICHSEN R, CHRISTIANSEN CF,MEHNERT F, et al. Colorectal cancer and risk of atrial fibrillation and flutter:a population-based casecontrol study[J]. Intern Emerg Med,2012, 7(5):431-438.
[30] LI C, WANG F, YANG Y, et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GenelD population[J].Hum Genet, 2011, 1 29(3):239-246.
[31] BENJAMIN EJ, RICE KM, ARKING DE, et al.Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry[J]. Nat Genet, 2009,41(8):879-881.
[32] TSAI CT, HSIEH CS, CHANG SN, et al.Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation[J].J Med Genet, 2015,52(1):28-36.
[33] ZHANG Z, YAMASHITA H, TOYAMA T, et al.ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer[J]. Clin Cancer Res,2005, 1 1(1):193-198.
[34] CHO YG, SONG JH, KIM CJ, et al.Genetic alterations of the ATBF] gene in gastric cancer[J]. Clin Cancer Res,2007, 13(15Pt 1):4355-4359.
[35]钟林,陈飞,李强,等.ATBF1在结直肠癌中的表达及其与转移相关性研究[J].昆明医科大学学报,2014, 35(6):37-41.
[36]纪术峰,钟林.结直肠癌中ATBF1基因功能分析[J].南方医科大学学报,2016,36(7):957-963.
[37] SUN X, ZHOU Y, OTTO KB, et al.Infrequent mutation of A TBF1 in human breast cancer[J].J Cancer Res Clin Oncol, 2007, 1 33(2):103-1 05.
[38]林志群,赵大川,陈飞,等.AT模体结合因子1对结直肠癌LOVO细胞增殖侵袭的影响[J].肿瘤防治研究,2016,43(4):267-271.
[39] SUN X, LI J, SICA G, et al. Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma[J]. Head Neck, 2013,35(7):1 007-1 014.
[40] KAWAGUCHI M, HARA N, BILIM V, et al.A diagnostic marker for superficial urothelial bladder carcinoma:lack of nuclear ATBF1(ZFHX3)by immunohistochemistry suggests malignant progression[J]. BMC Cancer,2016, 16(1):805.
[41] NISHIO E, MIURA Y, KAWAGUCHI M, et al.Nuclear translocation of ATBF1 is a potential prognostic marker for skin cancer[J]. Acta Dermatovenerol Croat,2012, 20(4):239-245.
[42] MORI Y, KATAOKA H, MIURA Y, et al.Subcellular localization of ATBF1regulates MUC5AC transcription in gastric cancer[J]. Int J Cancer, 2007,121(2):241-247.
[43] LI M, ZHANG C, ZHONG Y, et al.Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells[J]. Biochem Biophys Res Commun, 2017, 490(2):492-498.
[44] SUN X, LI J, DONG FN, et al.Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells[J].PLoS One, 2014, 9(3):e92746.
[45] MABUCHI M, KATAOKA H, MIURA Y,et al. Tumor suppressor, AT motif binding factor 1(ATBF1), translocates to the nucleus with runt domain transcription factor 3(RUNX3)in response to TGF-beta signal transduction[J]. Biochem Biophys Res Commun, 2010, 398(2):321-325.
[46] SAKATA N, KANEKO S, IKENO S,et al. TGF-βsignaling cooperates with AT motif-binding factor-1for repression of theα-fetoprotein promoter[J].J Signal Transduct, 2014,2014:970346.
[47] DONG XY, GUO P, SUN X, et al.Estrogen up-regulates ATBF1transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells[J]. J Biol Chem, 201 1,286(16):1 3879-1 3890.
[48] DONG XY, FU X, FAN S, et al.Oestrogen causes ATBF1 protein degradation through the oestrogenresponsive E3 ubiquitin ligase EFP[J].Biochem J, 2012, 444(3):581-590.
[49] DONG XY, SUN X, GUO P, et al.ATBF1 inhibits estrogen receptor(ER)function by selectively competing with AIB1 for binding to the ER in ERpositive breast cancer cells[J].J Biol Chem, 2010, 285(43):32801-32809.
[50] LI M, ZHAO D, MA G, et al.Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells[J]. Biochem Biophys Res Commun, 2013, 430(1):358-363.
[51] KASPAR P, DVORAKOVA M, KRALOVA J,et al. Myb-interacting protein, ATBF1,represses transcriptional activity of Myb oncoprotein[J].J Biol Chem, 1999,274(20):14422-14428.
[52]张荣贵,余永胜,臧国庆.c-myb及其在肝脏的表达和意义[J].肝脏,2007,12(3):212-214.
[53] NOJIRI S, JOH T, MIURA Y, et al. ATBF1enhances the suppression of STAT3signaling by interaction with PIAS3[J].Biochem Biophys Res Commun, 2004,314(1):97-103.
[54] GALOCZOVA M, COATES P, VOJTESEK B. STAT3, stem cells, cancer stem cells and p63[J]. Cell Mol Biol Lett, 2018,23:12.
[55] JOHNSON DE, O'KEEFE RA, GRANDIS JR.Targeting the IL-6/JAK/STAT3signalling axis in cancer[J]. Nat Rev Clin Oncol, 201 8, 1 5(4):234-248.
[56] ZHANG L, LI J, WANG Q, et al. The relationship between microRNAs and the STAT3-related signaling pathway in cancer[J]. Tumour Biol, 2017,39(7):101042831 7719869.
[57] JIANG Q, NI B, SHI J, et al. Downregulation of ATBF1 activates STAT3signaling via PIAS3 in pacinginduced HL-1 atrial myocytes[J].Biochem Biophys Res Commun, 2014,449(3):278-283.
[58] YANG XH, TANG F, SHIN J, et al.Incorporating genomic, transcriptomic and clinical data:a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma[J]. BMC Syst Biol, 2017, 11(Suppl 5):92.