MicroRNA与脑缺血后细胞凋亡的线粒体途径研究进展
摘要
<正>脑缺血是由于大脑内血管形成血栓或栓塞,导致局部脑组织坏死、凋亡和神经损伤。在治疗脑缺血时,恢复脑部血流供应则会引起再灌注损伤。脑缺血及其再灌注损伤的发病机制复杂,治疗困难。线粒体通过产生能量参与细胞的生命活动,脑缺血后脑组织缺血缺氧导致线粒体功能障碍,引起细胞
引文
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[7]Almeida M I,Rui M R,Calin G A. MicroRNA history:discovery,re-cent applications,and next frontiers[J]. Mutat Res,2011,717(1-2):1-8.
[8]Eva V,József B,Zoltán H. MicroRNA detection by northern blottingusing locked nucleic acid probes[J]. Nature Protocols,2008,3(2):190-196.
[9]Kren B T,Wong P Y,Sarver A,et al. MicroRNAs identified in highlypurified liver-derived mitochondria may play a role in apoptosis[J].Rna Biology,2009,6(1):65-72.
[10]Simonetta B,Silvia R,Muriel G,et al. Nuclear outsourcing of RNAinterference components to human mitochondria[J]. Plos One,2011,6(6):e20746.
[11]Sripada L,Tomar D,Singh R. Mitochondria:one of the destina-tions of microRNAs[J]. Mitochondrion,2012,12(6):593–599.
[12]Zhang X,Zuo X,Yang B,et al. MicroRNA directly enhances mito-chondrial translation during muscle differentiation[J]. Cell,2014,158(3):607-619.
[13]Zhen B,Li L M,Rui T,et al. Identification of mouse liver mitochon-dria-associated microRNAs and their potential biological functions[J]. Cell Research,2010,20(9):1076-1078.
[14]Fernandez S P,Enriquez J J. Replication and transcription of mam-malian mitochondrial DNA[J]. Exp Physiol,2003,88(1):41-56.
[15]Peifeng L,Jianqing J,Guifeng G,et al. Control of mitochondrial ac-tivity by microRNAs[J]. Journal of Cellular Biochemistry,2012,113(4):1104-1110.
[16]Kato M,Castro N E,Natarajan R. MicroRNAs:Potential Mediatorsand Biomarkers of Diabetic Complications[J]. Free Radic BiolMed,2013,64(5):85-94.
[17]Mcbride H M,Neuspiel M,Wasiak S. Mitochondria:more than justa powerhouse[J]. Current Biology,2006,16(14):551-560.
[18]Monteiro P,Oliveira P J,Gon alves L,et al. Mitochondria:role in is-chemia,reperfusion and cell death[J]. Revista Portuguesa De Car-diologia,2003,22(2):233-254.
[19] Thompson J W,Narayanan S V,Koronowski K B,et al. Signalingpathways leading to ischemic mitochondrial neuroprotection[J].Journal of Bioenergetics,2014,47(1-2):101-110.
[20] Lewis B P,Burge C B,Bartel D P. Conserved seed pairing,oftenflanked by adenosines,indicates that thousands of human genes areMicroRNA targets[J]. Cell,2005,120(1):15-20.
[21]Wulczyn F G,Smirnova L,Rybak A,et al. Post-transcriptional regu-lation of the let-7 microRNA during neural cell specification[J].FASEB J,2007,21(2):415-426.
[22]Hwang I K,Yoo KY,Lee C H,et al. Changes in the expression ofmitochondrial peroxiredoxin and thioredoxin in neurons and glia andtheir protective effects in experimental cerebral ischemic damage[J]. Free Radical Biology&Medicine,2010,48(9):1242-1251.
[23]Sanjay Y,Ankita P,Aruna S,et al. miR-497 and miR-302b regulateethanol-induced neuronal cell death through BCL2 protein and cyc-lin D2[J]. Journal of Biological Chemistry,2011,286(43):37347-37357.