Finding a way to preserve mitochondria: new pathogenic pathways in experimental multiple sclerosis
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  • 英文篇名:Finding a way to preserve mitochondria: new pathogenic pathways in experimental multiple sclerosis
  • 作者:Andrea ; Mancini ; Lorenzo ; Gaetani ; Lucia ; Gentili ; Massimiliano ; Di ; Filippo
  • 英文作者:Andrea Mancini;Lorenzo Gaetani;Lucia Gentili;Massimiliano Di Filippo;Clinica Neurologica, Dipartimento di Medicina, Università degli Studi di Perugia;
  • 中文刊名:SJZY
  • 英文刊名:中国神经再生研究(英文版)
  • 机构:Clinica Neurologica, Dipartimento di Medicina, Università degli Studi di Perugia;
  • 出版日期:2018-12-19
  • 出版单位:Neural Regeneration Research
  • 年:2019
  • 期:v.14
  • 基金:MDF received support by Fondazione Italiana Sclerosi Multipla(FISM)(project code 2013/R/12);; LGa received travel grants from Biogen-Idec,Biogen,Novartis,Teva,Genzyme;; MDF participated on advisory boards for and received speaker or writing honoraria and funding for travelling from Bayer,Biogen Idec,Genzyme,Merck,Novartis,Roche and Teva
  • 语种:英文;
  • 页:SJZY201901017
  • 页数:2
  • CN:01
  • ISSN:11-5422/R
  • 分类号:79-80
摘要
<正>Multiple sclerosis(MS)is a chronic disorder affecting central nervous system(CNS)in which inflammatory and neuro-degenerative features coexist since the earlier phases of the disease(Reich et al.,2018).During last years,attention has been directed toward the possible pathogenic pathways linking these two different features characterizing MS,in order to acquire a better understanding of the disease pathogenesis and to design new disease modifying therapies.Currently available therapies for MS are primarily aimed
        
引文
Campbell GR,Worrall JT,Mahad DJ(2014)The central role of mitochondria in axonal degeneration in multiple sclerosis.Mult Scler 20:1806-1813.
    Campbell GR,Ziabreva I,Reeve AK,Krishnan KJ,Reynolds R,Howell O,Lassmann H,Turnbull DM,Mahad DJ(2011)Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis.Ann Neurol 69:481-492.
    Di Filippo M,de Iure A,Giampa C,Chiasserini D,Tozzi A,Orvietani PL,Ghiglieri V,Tantucci M,Durante V,Quiroga-Varela A,Mancini A,Costa C,Sarchielli P,Fusco FR,Calabresi P(2016)Persistent activation of microglia and NADPH oxidase[corrected]drive hippocampal dysfunction in experimental multiple sclerosis.Sci Rep 6:20926.
    DiMauro S,Schon EA(2003)Mitochondrial respiratory-chain diseases.NEngl J Med 348:2656-2668.
    Dutta R,McDonough J,Yin X,Peterson J,Chang A,Torres T,Gudz T,Macklin WB,Lewis DA,Fox RJ,Rudick R,Mirnics K,Trapp BD(2006)Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients.Ann Neurol 59:478-489.
    Gao HM,Zhou H,Hong JS(2012)NADPH oxidases:novel therapeutic targets for neurodegenerative diseases.Trends Pharmacol Sci 33:295-303.
    Lu F,Selak M,O’Connor J,Croul S,Lorenzana C,Butunoi C,Kalman B(2000)Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis.J Neurol Sci 177:95-103.
    Mahad DJ,Ziabreva I,Campbell G,Lax N,White K,Hanson PS,Lassmann H,Turnbull DM(2009)Mitochondrial changes within axons in multiple sclerosis.Brain 132:1161-1174.
    Mancini A,Tantucci M,Mazzocchetti P,de Iure A,Durante V,Macchioni L,Giampa C,Alvino A,Gaetani L,Costa C,Tozzi A,Calabresi P,Di Filippo M(2018)Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis.Neurobiol Dis 113:97-108.
    Niki?I,Merkler D,Sorbara C,Brinkoetter M,Kreutzfeldt M,Bareyre FM,Bruck W,Bishop D,Misgeld T,Kerschensteiner M(2011)A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis.Nat Med 17:495-499.
    Reich DS,Lucchinetti CF,Calabresi PA(2018)Multiple Sclerosis.N Engl JMed 378:169-180.
    Smith KJ,Kapoor R,Hall SM,Davies M(2001)Electrically active axons degenerate when exposed to nitric oxide.Ann Neurol 49:470-476.
    Trapp BD,Stys PK(2009)Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis.Lancet Neurol 8:280-291.

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