摘要
探讨了环境友好和无毒性的轴手性多活性中心的BINOL酰胺催化的芳香醛、乙酰丙酮及碳酸氢铵的Hantzsch反应.研究表明,在回流条件下,CH_2Cl_2中,在0.075 mmol轴手性多活性中心BINOL酰胺存在下,芳香醛、乙酰丙酮及碳酸氢铵能有效进行Hantzsch反应,高产率生成Hantzsch酯.产物通过红外、核磁、熔点进行表征.该方法与现有合成方法相比,具有操作简便、收率高、用时短等优点,有潜在的应用前景.
The Hantzsch reaction of an environmentally friendly,axis chiral multiple BINOL amides catalyzing of aromatic aldehydes,acetacetic ester and ammonium bicarbonate has been developed. The results demonstrated that the Hantzsch reaction of aromatic aldehydes,acetacetic ester and ammonium bicarbonate was efficiently performed,Hantzsch ester formation was increased in reflux CH_2Cl_2 with axis chiral multiple BINOL amides(0. 075 mmol). The product was characterized by IR,NMR,melting point. Compared with the conventional synthesis method,ultrasonic method is simple,high yield,rapid and potential.
引文
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