摘要
目的探讨β受体阻滞剂治疗心力衰竭合并房颤患者的疗效及安全性。方法选取80例心力衰竭合并房颤患者随机分为2组,传统组采用传统治疗,β受体阻滞剂组则加用β受体阻滞剂,比较2组患者疾病相关指标、总体治疗效果、心功能Ⅰ~Ⅱ级率、生活质量与安全性。结果治疗后,β受体阻滞剂组患者静息心率、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、B型脑钠肽(BNP)、最大P波时限(Pmax)与P波离散度(Pd)水平均显著低于传统组(P <0. 01),左心室射血分数(LVEF)与6 min步行距离(6MWD)均显著高于传统组(P <0. 01);β受体阻滞剂组患者治疗后的生活质量整体得分显著低于传统组(P <0. 01);β受体阻滞剂组总有效率与治疗后心功能Ⅰ~Ⅱ级率显著高于传统组(P <0. 05); 2组药物不良反应率差异无统计学意义(P> 0. 05)。结论β受体阻滞剂治疗心力衰竭合并房颤患者的疗效显著,安全性较高。
Objective To investigate the efficacy and safety of β-blocker in the treatment of patients with heart failure and atrial fibrillation Methods A total of 80 patients with heart failure and atrial fibrillation admitted to hospital were randomly divided into two groups. The patients in the traditional group were treated with traditional therapy and those in the β-blocker group were treated withβ-receptor blocker defibrillators. Disease-related indicators,the overall treatment efficacy,Ⅰ ~ Ⅱgrade rate of heart function,quality of life and safety of the two groups were compared. Results After treatment,the resting heart rate,left ventricular end diastolic volume( LVEDV),left ventricular end systolic volume( LVESV),B-type natriuretic peptide( BNP),maximum P-wave duration( Pmax)and P-wave dispersion( Pd) levels in the β-blocker group were significantly lower than those in the traditional group( P < 0. 01); left ventricular ejection fraction( LVEF) and 6 min walk distance( 6MWD) after treatment were significantly higher than those in the traditional group( P < 0. 01).The β-blocker group had lower total quality of life score,higher the total effective rate and the cardiac function with grade Ⅰ ~ Ⅱ after treatment than the traditional group( P < 0. 05). There was no significant difference in drug adverse reaction between the two groups( P > 0. 05). Conclusion The β-blocker in the treatment of patients with heart failure and atrial fibrillation has significant efficacy,and it is safer in clinic application.
引文
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