miRNA在肾脏缺血再灌注损伤中的作用研究进展
摘要
肾脏缺血再灌注损伤(IRI)是导致急性肾损伤(AKI)的主要原因之一。肾脏IRI涉及炎症反应、氧化应激反应、细胞凋亡与自噬等过程。miRNA是内源性的、短链非编码RNA,可通过抑制靶m RNA的转录后活性影响转录后翻译过程。miRNA介导的基因调控是调节细胞周期、增殖、生长和凋亡等基本细胞过程的重要调节机制,进而对病理生理结果产生重要影响。研究显示miRNA在多种肾脏疾病发病过程中起关键作用,如IRI、AKI和肾癌。多种miRNA表现出差异性表达,可能通过调节炎症、氧化应激、细胞凋亡和自噬来减轻损伤反应,部分miRNA甚至表现出良好的诊断IRI致AKI的效能。本文就miRNA在肾脏IRI中的作用研究进展作一综述。
引文
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[3]Krol J,Loedige I,Filipowicz W.The wid espread regulation of mi croRNA biogenesis,function and decay[J].Nature Reviews Genetics,2010,11(9):597-610.
[4]Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
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[15]Paller MS,Hoidal JR,Ferris TF.Oxygen free radicals in ischemic acute renal failure in the rat[J].J Clin Invest,1984,74(4):1156-1164.
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[17]Kaushal GP,Shah SV.Autophagy in acute kidney injury[J].Kidney Int,2016,89(4):779-791.
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[28]Muratsu-Ikeda S,Nangaku M,Ikeda Y,et al.Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells[J].PLoS One,2012,7(7):e41462.
[29]R odrigues CE,Capcha JMC,de Bragan,c a AC,et al.Hu man umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury[J].Stem Cell Research&Therapy,2017,8(1):19.
[30]Yuan XP,Liu LS,Chen CB,et al.MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress[J].Oncotarget,2017,8(47):82064-82077.
[31]Guclu A,Kocak C,Kocak FE,et al.Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion[J].Ren Fail,2016,38(9):1468-1475.
[32]Yang S,Huang C,Li X,et al.miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN[J].Toxicology,2013(306):162-168.
[33]Zhang W,Shu L.Upregulation of miR-21 by Ghrelin Ameliorates Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Inflammation and Cell Apoptosis[J].DNA and Cell Biology,2016,35(8):417-425.
[34]Li Z,Deng X,Kang Z,et al.Elevation of miR-21,through targeting MKK3,may be involved in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury[J].Journal of Nephrology,2016,29(1):27-36.
[35]Lan YF,Chen HH,Lai PF,et al.MicroRNA-494 reduces ATF3expression and promotes AKI[J].J Am Soc Nephrol,2012,23(12):2012-2023.
[36]Zhu XY,Ebrahimi B,Eirin A,et al.Renal Vein Levels of MicroRNA-26a Are Lower in the Poststenotic Kidney[J].J Am Soc Nephrol,2015,26(6):1378-1388.
[37]Liang S,Wang W,Gou X.MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury[J].Molecular Immunology,2015,65(2):321-327.
[38]Amrouche L,Desbuissons G,Rabant M,et al.MicroRNA-146a in Human and Experimental Ischemic AKI:CXCL8-Dependent Mechanism of Action[J].J Am Soc Nephrol,2017,28(2):479-493.
[39]Xu X,Kriegel AJ,Liu Y,et al.Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21[J].Kidney International,2012,82(11):1167-1175.
[40]Cui R,Xu J,Chen X,et al.Global miRNA expression is temporally correlated with acute kidney injury in mice[J].Peer J,2016,4(2):e1729.
[41]Bhatt K,Wei Q,Pabla N,et al.MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury[J].J Am Soc Nephrol,2015,26(7):1588-1596.
[42]Hao J,Wei Q,Mei S,et al.Induction of microRNA-17-5p by p53protects against renal ischemia-reperfusion injury by targeting death receptor 6[J].Kidney International,2017,91(1):106-118.
[43]Liu X,Hong Q,Wang Z,et al.MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury[J].American Journal of Nephrology,2015,42(2):168-175.
[44]Lorenzen JM,Kaucsar T,Schauerte C,et al.MicroRNA-24 antagonism prevents renal ischemia reperfusion injury[J].J Am Soc Nephrol,2014,25(12):2717-2729.
[45]Zheng G,Wen X,Wang Y,et al.MicroRNA-381-induced downregulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury[J].Journal of Cellular Biochemistry,2018,119(4):3149-3161.
[46]Song T,Chen M,Rao Z,et al.miR-17-92 ameliorates renal ischemia reperfusion injury[J].The Kaohsiung Journal of Medical Sciences,2018,34(5):263-273.
[47]Jamadarkhana P,Chaudhary A,Chhipa L,et al.Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor(TRC160334)Ameliorates Ischemic Acute Kidney Injury[J].American Journal of Nephrology,2012,36(3):208-218.
[48]Bernhardt WM,Campean V,Kany S,et al.Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure[J].J Am Soc Nephrol,2006,17(7):1970-1978.
[49]Masson N,Ratcliffe PJ.HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2)levels[J].J Cell Sci,2003,116(Pt 15):3041-3049.
[50]Aguado-Fraile E,Ramos E,Saenz-Morales D,et al.miR-127 protects proximal tubule cells against ischemia/reperfusion:identification of kinesin family member 3B as miR-127 target[J].PLoS One,2012,7(9):e44305.
[51]Wang I,Sun K,Tsai T,et al.MiR-20a-5p mediates hypoxiainduced autophagy by targeting ATG16L1 in ischemic kidney injury[J].Life Sciences,2015,136(1):133-141.
[52]Wei Q,Liu Y,Liu P,et al.MicroRNA-489 Induction by HypoxiaInducible Factor-1 Protects against Ischemic Kidney Injury[J].J Am Soc Nephrol,2016,27(9):2784-2796.
[2]Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843.
[3]Krol J,Loedige I,Filipowicz W.The wid espread regulation of mi croRNA biogenesis,function and decay[J].Nature Reviews Genetics,2010,11(9):597-610.
[4]Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
[5]Ma Z,Wei Q,Dong G,et al.DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells[J].Biochimica et Biophysica Acta(BBA)-Molecular Basis of Disease,2014,1842(7):1088-1096.
[6]Humphreys BD,Valerius MT,Kobayashi A,et al.Intrinsic Epithelial Cells Repair the Kidney after Injury[J].Cell Stem Cell,2008,2(3):284-291.
[7]Witzgall R,Brown D,Schwarz C,et al.Localization of proliferating cell nuclear antigen,vimentin,c-Fos,and clusterin in the postischemic kidney.Evidence for a heterogenous genetic response among nephron segments,and a large pool of mitotically active and dedifferentiated cells[J].Journal of Clinical Investigation,1994,93(5):2175-2188.
[8]Stroo I,Stokman G,Teske GJ,et al.Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase[J].Int Immunol,2010,22(6):433-442.
[9]Furuichi K,Wada T,Yokoyama H,et al.Role of Cytokines and Chemokines in Renal Ischemia-Reperfusion Injury[J].Drug News Perspect,2002,15(8):477-482.
[10]Gonullu E,Ozkardesler S,Kume T,et al.Comparison of the effects of dexmedetomidine administered at two different times on renal ischemia/reperfusion injury in rats[J].Braz J Anesthesiol,2014,64(3):152-158.
[11]Si Y,Bao H,Han L,et al.Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation[J].J Transl Med,2013,11(1):141.
[12]Linas SL,Whittenburg D,Parsons PE,et al.Ischemia increases neutrophil retention and worsens acute renal failure:Role of oxygen metabolites and ICAM 1[J].Kidney International,1995,48(5):1584-1591.
[13]Sheridan AM,Bonventre JV.Cell biology and molecular mechanisms of injury in ischemic acute renal failure[J].Curr Opin Nephrol Hypertens,2000,9(4):427-434.
[14]Bonventre JV.Mechanisms of ischemic acute renal failure[J].Kidney International,1993,43(5):1160-1178.
[15]Paller MS,Hoidal JR,Ferris TF.Oxygen free radicals in ischemic acute renal failure in the rat[J].J Clin Invest,1984,74(4):1156-1164.
[16]Kehrer JP,Klotz LO.Free radicals and related reactive species as mediators of tissue injury and disease:implications for Health[J].Crit Rev Toxicol,2015,45(9):765-798.
[17]Kaushal GP,Shah SV.Autophagy in acute kidney injury[J].Kidney Int,2016,89(4):779-791.
[18]Ishihara M,Urushido M,Hamada K,et al.Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury[J].American Journal of Physiology-Renal Physiology,2013,305(4):F495-F509.
[19]Alers S,Loffler AS,Wesselborg S,et al.Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy:Cross Talk,Shortcuts,and Feedbacks[J].Molecular and Cellular Biology,2011,32(1):2-11.
[20]Russell RC,Tian Y,Yuan H,et al.ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase[J].Nature Cell Biology,2013,15(7):741-750.
[21]Shukla S,Patric IR,Patil V,et al.Methylation silencing of ULK2,an autophagy gene,is essential for astrocyte transformation and tumor growth[J].J Biol Chem,2014,289(32):22306-22318.
[22]Tsuyuki S,Takabayashi M,Kawazu M,et al.Detection of WIPI1mRNA as an indicator of autophagosome formation[J].Autophagy,2014,10(3):497-513.
[23]Liang M,Liu Y,Mladinov D,et al.MicroRNA:a new frontier in kidney and blood pressure research[J].American Journal of Physiology-Renal Physiology,2009,297(3):F553-F558.
[24]Naesens M,Sarwal MM.Molecular diagnostics in transplantation[J].Nat Rev Nephrol,2010,6(10):614-628.
[25]Zhang L,Xu Y,Xue S,et al.Implications of dynamic changes in miR-192 expression in ischemic acute kidney injury[J].International Urology and Nephrology,2017,49(3):541-550.
[26]Wang N,Zhou Y,Jiang L,et al.Urinary microRNA-10a and microRNA-30d serve as novel,sensitive and specific biomarkers for kidney injury[J].PLo S One,2012,7(12):e51140.
[27]Saikumar J,Hoffmann D,Kim T,et al.Expression,Circulation,and Excretion Profile of MicroRNA-21,-155,and-18a Following Acute Kidney Injury[J].Toxicological Sciences,2012,129(2):256-267.
[28]Muratsu-Ikeda S,Nangaku M,Ikeda Y,et al.Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells[J].PLoS One,2012,7(7):e41462.
[29]R odrigues CE,Capcha JMC,de Bragan,c a AC,et al.Hu man umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury[J].Stem Cell Research&Therapy,2017,8(1):19.
[30]Yuan XP,Liu LS,Chen CB,et al.MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress[J].Oncotarget,2017,8(47):82064-82077.
[31]Guclu A,Kocak C,Kocak FE,et al.Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion[J].Ren Fail,2016,38(9):1468-1475.
[32]Yang S,Huang C,Li X,et al.miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN[J].Toxicology,2013(306):162-168.
[33]Zhang W,Shu L.Upregulation of miR-21 by Ghrelin Ameliorates Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Inflammation and Cell Apoptosis[J].DNA and Cell Biology,2016,35(8):417-425.
[34]Li Z,Deng X,Kang Z,et al.Elevation of miR-21,through targeting MKK3,may be involved in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury[J].Journal of Nephrology,2016,29(1):27-36.
[35]Lan YF,Chen HH,Lai PF,et al.MicroRNA-494 reduces ATF3expression and promotes AKI[J].J Am Soc Nephrol,2012,23(12):2012-2023.
[36]Zhu XY,Ebrahimi B,Eirin A,et al.Renal Vein Levels of MicroRNA-26a Are Lower in the Poststenotic Kidney[J].J Am Soc Nephrol,2015,26(6):1378-1388.
[37]Liang S,Wang W,Gou X.MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury[J].Molecular Immunology,2015,65(2):321-327.
[38]Amrouche L,Desbuissons G,Rabant M,et al.MicroRNA-146a in Human and Experimental Ischemic AKI:CXCL8-Dependent Mechanism of Action[J].J Am Soc Nephrol,2017,28(2):479-493.
[39]Xu X,Kriegel AJ,Liu Y,et al.Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21[J].Kidney International,2012,82(11):1167-1175.
[40]Cui R,Xu J,Chen X,et al.Global miRNA expression is temporally correlated with acute kidney injury in mice[J].Peer J,2016,4(2):e1729.
[41]Bhatt K,Wei Q,Pabla N,et al.MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury[J].J Am Soc Nephrol,2015,26(7):1588-1596.
[42]Hao J,Wei Q,Mei S,et al.Induction of microRNA-17-5p by p53protects against renal ischemia-reperfusion injury by targeting death receptor 6[J].Kidney International,2017,91(1):106-118.
[43]Liu X,Hong Q,Wang Z,et al.MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury[J].American Journal of Nephrology,2015,42(2):168-175.
[44]Lorenzen JM,Kaucsar T,Schauerte C,et al.MicroRNA-24 antagonism prevents renal ischemia reperfusion injury[J].J Am Soc Nephrol,2014,25(12):2717-2729.
[45]Zheng G,Wen X,Wang Y,et al.MicroRNA-381-induced downregulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury[J].Journal of Cellular Biochemistry,2018,119(4):3149-3161.
[46]Song T,Chen M,Rao Z,et al.miR-17-92 ameliorates renal ischemia reperfusion injury[J].The Kaohsiung Journal of Medical Sciences,2018,34(5):263-273.
[47]Jamadarkhana P,Chaudhary A,Chhipa L,et al.Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor(TRC160334)Ameliorates Ischemic Acute Kidney Injury[J].American Journal of Nephrology,2012,36(3):208-218.
[48]Bernhardt WM,Campean V,Kany S,et al.Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure[J].J Am Soc Nephrol,2006,17(7):1970-1978.
[49]Masson N,Ratcliffe PJ.HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2)levels[J].J Cell Sci,2003,116(Pt 15):3041-3049.
[50]Aguado-Fraile E,Ramos E,Saenz-Morales D,et al.miR-127 protects proximal tubule cells against ischemia/reperfusion:identification of kinesin family member 3B as miR-127 target[J].PLoS One,2012,7(9):e44305.
[51]Wang I,Sun K,Tsai T,et al.MiR-20a-5p mediates hypoxiainduced autophagy by targeting ATG16L1 in ischemic kidney injury[J].Life Sciences,2015,136(1):133-141.
[52]Wei Q,Liu Y,Liu P,et al.MicroRNA-489 Induction by HypoxiaInducible Factor-1 Protects against Ischemic Kidney Injury[J].J Am Soc Nephrol,2016,27(9):2784-2796.