血清CA72-4、CA242、CA19-9和CEA联合检测对胃癌的诊断价值
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摘要
目的:探究血清癌抗原(CA)72-4、CA242、CA19-9和癌胚抗原(CEA)联合检测诊断胃癌的价值及预后评估。方法 :选取132例胃癌患者及132例健康志愿者为研究对象,分为胃癌组和对照组,检测两组血清中CA72-4、CA242、CA19-9和CEA含量,比较单项指标和多项指标联合检测的灵敏度、特异度、准确度、阴性预测值、阳性预测值,随访3年,比较肿瘤标志物阳性与阴性患者复发转移概率。结果 :胃癌组血清CA19-9、CEA、CA72-4、CA242明显高于对照组,差异有统计学意义(P<0.05);4项肿瘤标志物联合检测的灵敏度及准确度明显高于单项指标检测(P<0.05);血清CA19-9、CEA、CA72-4和CA242阳性患者发生复发转移的概率高于阴性患者(P<0.05)。结论 :血清CA72-4、CA242、CA19-9和CEA联合检测可提高胃癌诊断的灵敏度和准确度,提示肿瘤复发转移,评估预后,具有一定的临床指导价值。
Objective: To investigate the value of combined detection of serum cancer antigen(CA) 72-4, CA242, CA19-9 and carcinoembryonic antigen(CEA) in the diagnosis and prognostic evaluation of gastric cancer. Methods: 132 patients with gastric cancer and 132 healthy volunteers were selected as subjects investigated and divided into gastric cancer group and control group. The levels of serum CA72-4, CA242, CA19-9 and CEA in the two groups were measured, and the sensitivity, specificity, accuracy, negative predictive value and positive predictive value of single index and combined detection of multiple indexes were compared. After 3 years of follow-up, the probability of recurrence and metastasis of tumor marks-positive and negative patients was compared. Results: The levels of serum CA19-9, CEA, CA72-4 and CA242 in the gastric cancer group were significantly higher than those in the control group(P<0.05). The sensitivity and accuracy of the combined detection of above 4 tumor markers were significantly higher than those of single detection(P<0.05). The serum CA19-9, CEA, CA72-4 and CA242-positive patients had a higher probability of recurrence and metastasis than serum CA19-9, CEA, CA72-4 and CA242-negative patients(P<0.05). Conclusion: The combined detection of serum CA72-4, CA242, CA19-9 and CEA can improve the sensitivity and accuracy of gastric cancer diagnosis, which can suggest tumor recurrence and metastasis and evaluate prognosis, and has certain clinical guiding value.
Objective: To investigate the value of combined detection of serum cancer antigen(CA) 72-4, CA242, CA19-9 and carcinoembryonic antigen(CEA) in the diagnosis and prognostic evaluation of gastric cancer. Methods: 132 patients with gastric cancer and 132 healthy volunteers were selected as subjects investigated and divided into gastric cancer group and control group. The levels of serum CA72-4, CA242, CA19-9 and CEA in the two groups were measured, and the sensitivity, specificity, accuracy, negative predictive value and positive predictive value of single index and combined detection of multiple indexes were compared. After 3 years of follow-up, the probability of recurrence and metastasis of tumor marks-positive and negative patients was compared. Results: The levels of serum CA19-9, CEA, CA72-4 and CA242 in the gastric cancer group were significantly higher than those in the control group(P<0.05). The sensitivity and accuracy of the combined detection of above 4 tumor markers were significantly higher than those of single detection(P<0.05). The serum CA19-9, CEA, CA72-4 and CA242-positive patients had a higher probability of recurrence and metastasis than serum CA19-9, CEA, CA72-4 and CA242-negative patients(P<0.05). Conclusion: The combined detection of serum CA72-4, CA242, CA19-9 and CEA can improve the sensitivity and accuracy of gastric cancer diagnosis, which can suggest tumor recurrence and metastasis and evaluate prognosis, and has certain clinical guiding value.
引文
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[2]黄道桂,任传路,虞红艳,等.血清PGⅠ,PGⅡ,TK1,TSGF,CEA与CA724联合检测在胃癌诊断中的应用价值[J].现代检验医学杂志,2015,30(1):101-104.
[3]Xu HX,Liu L,Xiang JF,et al.Postoperative serum CEA and CA125 levels are supplementary to perioperative CA19-9levels in predicting operative outcomes of pancreatic ductal adenocarcinoma[J].Surgery,2017,161(2):373-384.
[4]Jiang XT,Tao HQ,Zou SC.Detection of serum tumor markers in the diagnosis and treatment of patients with pancreatic cancer[J].Hepatobiliary Pancreat Dis Int,2004,3(3):464-468.
[5]黄星铭,闵晓霞.血清CEA、CA199、CA724联合检测在胃癌中的诊断价值[J].热带医学杂志,2012,12(12):1465-1466,1484.
[6]谢海涛.肿瘤标志物CA724、CA199、CA242、CEA联合检测在老年胃癌诊断中的应用[J].中国老年学杂志,2017,37(1):127-129.
[7]Jing JX,Wang Y,Xu XQ,et al.Tumor markers for diagnosis,monitoring of recurrence and prognosis in patients with upper gastrointestinal tract cancer[J].Asian Pac J Cancer Prev,2014,15(23):10267-10272.
[8]徐明星,李曼,彭波,等.肿瘤标志物联检在胃癌早期诊断临床应用研究[J].中国实验诊断学,2014,18(6):899-902.