非洛地平缓释片和厄贝沙坦对高血压病人左室重构的影响
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摘要
目的观察非洛地平缓释片和厄贝沙坦对高血压病人左室重构的影响。方法根据病人服药情况,将150例高血压合并左室肥厚受试者分为3组,每组50例。A组服用非洛地平缓释片治疗;B组服用厄贝沙坦治疗;C组服用安慰剂。分别于治疗前、治疗后6个月、治疗后12个月检测各组病人血压值、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室质量指数(LVMI)、血浆前胶原羧基蛋白酶(PICP)、人Ⅲ型前胶原肽(PⅢNP)、基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制因子-1(TIMP-1)水平。比较3组病人脑血管意外、急性左心衰竭、高血压危急症、死亡等发生率。结果在服药6个月和12个月后,A组和B组病人收缩压和舒张压水平较C组显著降低(P <0.05)。在服药6个月和12个月后,A组和B组病人LVEDV、LVESV、LVMI、LVDD、LPWT、LVST、PICP、PⅢNP、MMP-9、TIMP-1水平较C组显著降低(P <0.05)。与C组比较,A组和B组病人急性左心衰竭、脑血管意外、高血压危急症发生率显著降低(P <0.05)。结论非洛地平缓释片和厄贝沙坦均可有效改善高血压病人左室重构,缓解病人临床症状。
引文
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[19]XIE X R,YANG P.Effect of loading-dose ticagrelor on coronary blood flow,left ventricular remodeling and myocardial enzyme spectrum in patients with acute myocardial infarction after interventional therapy[J].Journal of Hainan Medical University,2016,22(24):17-20.
[20]刘爽,马春燕,李阳,等.左心室整体纵向应变预测急性心肌梗死患者经皮冠状动脉介入术后左心室重构[J].中国医学影像技术,2016,32(3):363-366.
[2]VIVEIROS M A,MARTINS O M,SILVA C P,et al.Time to left ventricular reverse remodeling after cardiac resynchronization therapy:better late than never[J].Revista Portuguesa De Cardiologia(English Edition),2016,35(3):161-167.
[3]蹇晓东,王冬,李卉.ACEI及ARB治疗老年慢性充血性心力衰竭患者左心室重构的临床疗效[J].山东医药,2016,56(5):48-50.
[4]SU A K,PARK S M,KIM M N,et al.Assessment of left ventricular function by layer-specific strain and its relationship to structural remodeling in hypertensive patients[J].Canadian Journal of Cardiology,2016,32(2):211-216.
[5]周云,渠乐,朱小莉.瑞舒伐他汀与阿托伐他汀治疗非ST段抬高型急性心肌梗死患者对炎症因子及左室重构的影响[J].海南医学院学报,2016,22(13):1390-1393.
[6]孙琳,何怡华,赵映,等.斑点追踪技术研究扩张型心肌病左室重构、应变和收缩功能的相关性[J].中国超声医学杂志,2016,32(3):208-210.
[7]MICHEL F S,MAGUBANE M,MOKOTEDI L,et al.Sex-specific effects of adrenergic-induced left ventricular remodeling in spontaneously hypertensive rats[J].Journal of Cardiac Failure,2017,23(2):161-168.
[8]孙阿林,潘斌,周鹏,等.AMI-PCI应用冻干重组人脑利钠肽对左室重构的影响[J].实用药物与临床,2016,19(1):30-34.
[9]任志静,张晶,丛洪良.H型高血压与左心室重构的关系探讨[J].天津医药,2016,44(3):356-359.
[10]何新兵,温志浩,刘雪玲,等.实时三维超声心动图评价养心通脉饮对慢性心力衰竭患者左室重构的治疗效果[J].广州中医药大学学报,2016,33(6):772-775.
[11]JACLYN C,DAVID C,CAROLINE H,et al.Remote zone extracellular volume and left ventricular remodeling in survivors of ST-elevation myocardial infarction[J].Hypertension,2016,68(2):385-391.
[12]EGUCHI A,NAITO Y,LWASAKU T,et al.Association of dietary iron restriction with left ventricular remodeling after myocardial infarction in mice[J].Heart&Vessels,2016,31(2):222-229.
[13]万小亮,梁健球.依那普利叶酸片对慢性心力衰竭并高同型半胱氨酸血症患者左室重构的影响[J].中国心血管病研究,2016,14(2):149-152.
[14]HENNING R J,KHAN A,JIMENEZ E.Chitosan hydrogels significantly limit left ventricular infarction and remodeling and preserve myocardial contractility[J].Journal of Surgical Research,2016,201(2):490-497.
[15]SUTTON M S J,LINDE C,GOLD M R,et al.Left ventricular architecture,long-term reverse remodeling,and clinical outcome in mild heart failure with cardiac resynchronization:results from the reverse trial[J].Jacc Heart Failure,2017,5(3):169-178.
[16]杨忆微,郎伟红,韩旭晨.丹红注射液对缺血性心肌病心力衰竭患者神经内分泌因子、左室重构及心功能的影响[J].辽宁中医杂志,2016,43(10):2136-2137.
[17]彭艳,程娟.急诊与择期经皮冠状动脉介入术对ST段抬高型心肌梗死患者左室重构及心功能影响的对比研究[J].实用心脑肺血管病杂志,2016,24(5):68-70.
[18]NA H M,CHO G Y,LEE J M,et al.Echocardiographic predictors for left ventricular remodeling after acute ST elevation myocardial infarction with low risk group:speckle tracking analysis[J].Journal of Cardiovascular Ultrasound,2016,24(2):128-134.
[19]XIE X R,YANG P.Effect of loading-dose ticagrelor on coronary blood flow,left ventricular remodeling and myocardial enzyme spectrum in patients with acute myocardial infarction after interventional therapy[J].Journal of Hainan Medical University,2016,22(24):17-20.
[20]刘爽,马春燕,李阳,等.左心室整体纵向应变预测急性心肌梗死患者经皮冠状动脉介入术后左心室重构[J].中国医学影像技术,2016,32(3):363-366.