可降解下腔静脉滤器的生物力学性能及有限元分析
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摘要
利用有限元分析和径向支撑力测试,分析不同支撑杆数目对新型生物可降解下腔静脉滤器(inferior vena cava filters, IVCF)的生物力学性能的影响。应用三维建模软件建立支撑杆数目为8, 10, 12的IVCF模型;通过室温拉伸左旋聚乳酸得到其应力-应变曲线,使用Abaqus软件模拟分析3种支架在压握和自扩张过程中的生物力学性能;同时将3种IVCF进行径向支撑力测试。结果表明,3种支架的应力峰值不同,但应力分布趋势相同;其径向支撑力随支撑杆数目的增加而减小,自扩张性能则与之相反;10杆IVCF表现出较好的综合力学性能,经压握后不仅有足够的径向支撑力,而且可以实现自我扩张,对血管壁的损伤最小。
The effects of support pole numbers on biomechanical properties of a novel biodegradable inferior vena cava filter(IVCF) were investigated by finite element analysis and radial force tests. The IVCF model with 8, 10 and 12 supporting poles were established by three-dimensional modeling software. The stress-strain curve of poly L-lactide fibers was obtained by tensile test at room temperature. The biomechanical properties of the three stents under crimp and expansion condition were then simulated and analyzed by using the Abaqus software. Meanwhile, the three IVCFs were subjected to radial support force test. The results show that the three stents shows different peak stresses with similar trend of stress distribution. The radial support force decreases with the increase in the supporting pole numbers. However, the self-expansion performance shows the opposite trends. The 10 pole IVCF performs the superior comprehensive mechanical property, which includes sufficient radial force after crimp, achievement of self-expansion, and the least damage to vessel wall.
The effects of support pole numbers on biomechanical properties of a novel biodegradable inferior vena cava filter(IVCF) were investigated by finite element analysis and radial force tests. The IVCF model with 8, 10 and 12 supporting poles were established by three-dimensional modeling software. The stress-strain curve of poly L-lactide fibers was obtained by tensile test at room temperature. The biomechanical properties of the three stents under crimp and expansion condition were then simulated and analyzed by using the Abaqus software. Meanwhile, the three IVCFs were subjected to radial support force test. The results show that the three stents shows different peak stresses with similar trend of stress distribution. The radial support force decreases with the increase in the supporting pole numbers. However, the self-expansion performance shows the opposite trends. The 10 pole IVCF performs the superior comprehensive mechanical property, which includes sufficient radial force after crimp, achievement of self-expansion, and the least damage to vessel wall.
引文
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[12]仇洪然,冯海全,王惟颢,等.不同支撑杆数目腔静脉滤器的生物力学性能和血流动力学分析[J].医用生物力学,2015,30(4):304-310.
[13]HAKKARAINEN M.Aliphatic polyesters:abiotic and biotic degradation and degradation products[M]//Degradable Aliphatic Polyesters.Berlin Heidelberg:Springer,2002.
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[15]LOPES M S,JARDINI A L,FILHO R M.Poly(Lactic Acid)production for tissue engineering applications[J].Procedia Engineering,2012,42:1402-1413.
[16]林峰,刘祥坤,黄男男,等.基于有限元技术的镍钛金属支架的优化设计[J].中国医疗器械杂志,2014,38(2):98-101.
[2]CROWTHER M A.Inferior vena cava filters in the management of venous thromboembolism[J].American Journal of Medicine,2007,120(S2):S13-S17.
[3]LACHIEWICZ P F.Prevention of symptomatic pulmonary embolism in patients undergoing total hip and knee arthroplasty:clinical guideline of the American Academy of Orthopaedic Surgeons[C]//AZAR F,O'CONNOR M.Instructional Course Lectures.Rosemont:American Academy of Orthopedic Surgeons,2009,58:795-804.
[4]KIM H S,YOUNG M J,NARAYAN A K,et al.Acomparison of clinical outcomes with retrievable and permanent inferior vena cava filters[J].Journal of Vascular and Interventional Radiology,2008,19(3):393-399.
[5]NICHOLSON W,NICHOLSON W J,TOLERICO P,et al.Prevalence of fracture and fragment embolization of Bard retrievable vena cava filters and clinical implications including cardiac perforation and tamponade[J].Archives of Internal Medicine,2010,170(20):1827-1831.
[6]SANO M,UNNO N,YAMAMOTO N,et al.Frequent fracture of TrapEase inferior vena cava filters:a longterm follow-up assessment[J].Archives of Internal Medicine,2012,172(2):189-191.
[7]ZHOU D Y,SPAIN J,MOON E,et al.Retrospective review of 120 celect inferior vena cava filter retrievals:experience at a single institution[J].Journal of Vascular and Interventional Radiology,2012,23(12):1557-1563.
[8]王小平,肖越勇,吴斌,等.基于可降解材料构建的腔静脉滤器[J].中国组织工程研究与临床康复,2011,15(12):2133-2137.
[9]EGGERS M D,MCARTHUR M J,FIGUEIRA T A,et al.Pilot in vivo study of an absorbable polydioxanone vena cava filter[J].Journal of Vascular Surgery:Venous and Lymphatic Disorders,2015,3(4):409-420.
[10]赵辉,张福先,李海磊,等.新型生物可降解腔静脉滤器的设计研究[J].首都医科大学学报,2015,36(1):28-33.
[11]LORCH H,DALLMANN A,ZWAAN M,et al.Efficacy of permanent and retrievable vena cava filters:experimental studies and evaluation of a new device[J].Cardiovascular and Interventional Radiology,2002,25(3):193-199.
[12]仇洪然,冯海全,王惟颢,等.不同支撑杆数目腔静脉滤器的生物力学性能和血流动力学分析[J].医用生物力学,2015,30(4):304-310.
[13]HAKKARAINEN M.Aliphatic polyesters:abiotic and biotic degradation and degradation products[M]//Degradable Aliphatic Polyesters.Berlin Heidelberg:Springer,2002.
[14]GIRONI F,PIEMONTE F G V.Bioplastics and petroleum-based plastics:strengths and weaknesses[J].Energy Sources,Part A:Recovery,Utilization,and Environmental Effects,2011,33(21):1949-1959.
[15]LOPES M S,JARDINI A L,FILHO R M.Poly(Lactic Acid)production for tissue engineering applications[J].Procedia Engineering,2012,42:1402-1413.
[16]林峰,刘祥坤,黄男男,等.基于有限元技术的镍钛金属支架的优化设计[J].中国医疗器械杂志,2014,38(2):98-101.