小叶地不容块根的化学成分研究
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摘要
目的:研究小叶地不容块根的化学成分。方法:应用多种柱色谱技术进行分离纯化,通过波谱数据和理化性质鉴定化合物的结构。结果:从小叶地不容块根中分离鉴定了11个化合物,分别为:去氢克班宁(1)、左旋四氢巴马汀(2)、克班宁(3)、(-)-sukhodianine-β-N-oxide(4)、promucosine(5)、(-)-sukhodianine(6)、4-hydroxycrebanine(7)、N-methylasimilobine-2-O-β-D-glucopyranoside(8)、巴马汀(9)、(+)-stepharine(10)、(-)-asimilobine(11)。结论:其中,化合物5为首次从千金藤属植物中分离得到,化合物5、7、8和10为首次从该植物中分离得到。
Objective: To study the chemical constituents from the tuberous roots of Stephania succifera. Methods: The compounds were isolated and purified by various chromatographic methods,and their structures were elucidated by spectroscopic methods and physicochemical properties. Results: Eleven alkaloids were isolated and identified as dehydrocrebanine( 1),L-tetrahydropalmatine( 2),crebanine( 3),(-)-sukhodianine-β-N-oxide( 4),promucosine( 5),(-)-sukhodianine( 6),4-hydroxycrebanine( 7),N-methylasimilobine-2-O-β-D-glucopyranoside( 8),palmatine( 9),( +)-stepharine( 10) and(-)-asimilobine( 11). Conclusion: Compound 5 is isolated from Stephania genus for the first time,and compounds 5,7,8 and 10 are isolated from this plant for the first time.
Objective: To study the chemical constituents from the tuberous roots of Stephania succifera. Methods: The compounds were isolated and purified by various chromatographic methods,and their structures were elucidated by spectroscopic methods and physicochemical properties. Results: Eleven alkaloids were isolated and identified as dehydrocrebanine( 1),L-tetrahydropalmatine( 2),crebanine( 3),(-)-sukhodianine-β-N-oxide( 4),promucosine( 5),(-)-sukhodianine( 6),4-hydroxycrebanine( 7),N-methylasimilobine-2-O-β-D-glucopyranoside( 8),palmatine( 9),( +)-stepharine( 10) and(-)-asimilobine( 11). Conclusion: Compound 5 is isolated from Stephania genus for the first time,and compounds 5,7,8 and 10 are isolated from this plant for the first time.
引文
[1]刘玉壶.中国植物志[M].30(1)卷.北京:科学出版社,1996.
[2]杨德兰.小叶地不容块根中具有生理活性的生物碱成分研究[D].海口:海南大学,2010.
[3]魏代静.红厚壳和小叶地不容的化学成分及生物活性研究[D].青岛:青岛科技大学,2011.
[4]Yang DL,Mei WL,Wang H,et al.Antimicrobial alkaloids from the tubers of Stephania succifera[J].Z Naturforsch B,2010,65(6):757-761.
[5]况燚.大叶地不容块根生物碱及其生物活性研究[D].杨凌:西北农林科技大学,2010.
[6]Chang FR,Chen CY,Wu PH,et al.New alkaloids from Annona purpurea[J].J Nat Prod,2000,63(6):746-748.
[7]Kunitomo J,Oshikata M,Murakami Y.Studies on the alkaloids of Menispermaceous plants.CCLXXI.4-hydroxycrebanine,a new 4-hydroxyaporphine alkaloid,and(R)-roemeroline from Stephania sasakii Hayata[J].Chem Pharm Bull,1981,29(8):2251-2253.
[8]Kashiwaba N,Ono M,Toda J,et al.Aporphine glycosides from Stephania cepharantha seeds[J].J Nat Prod,2000,63(4):477-479.
[9]Costa EV,Chaves Sampaio MF,Salvador MJ,et al.Chemical constituents from the stem bark of Annona pickelii(Annonaceae)[J].Quím Nova,2015,38(6):769-776.
[2]杨德兰.小叶地不容块根中具有生理活性的生物碱成分研究[D].海口:海南大学,2010.
[3]魏代静.红厚壳和小叶地不容的化学成分及生物活性研究[D].青岛:青岛科技大学,2011.
[4]Yang DL,Mei WL,Wang H,et al.Antimicrobial alkaloids from the tubers of Stephania succifera[J].Z Naturforsch B,2010,65(6):757-761.
[5]况燚.大叶地不容块根生物碱及其生物活性研究[D].杨凌:西北农林科技大学,2010.
[6]Chang FR,Chen CY,Wu PH,et al.New alkaloids from Annona purpurea[J].J Nat Prod,2000,63(6):746-748.
[7]Kunitomo J,Oshikata M,Murakami Y.Studies on the alkaloids of Menispermaceous plants.CCLXXI.4-hydroxycrebanine,a new 4-hydroxyaporphine alkaloid,and(R)-roemeroline from Stephania sasakii Hayata[J].Chem Pharm Bull,1981,29(8):2251-2253.
[8]Kashiwaba N,Ono M,Toda J,et al.Aporphine glycosides from Stephania cepharantha seeds[J].J Nat Prod,2000,63(4):477-479.
[9]Costa EV,Chaves Sampaio MF,Salvador MJ,et al.Chemical constituents from the stem bark of Annona pickelii(Annonaceae)[J].Quím Nova,2015,38(6):769-776.