摘要
目的:探讨CD8+肿瘤浸润淋巴细胞(TIL)与乳腺癌患者临床病理特征及生存期的关系。方法:用免疫组化法检测112例乳腺癌肿瘤切片CD8+TIL的表达;根据表达情况将患者分为CD8+TIL阳性组与CD8+TIL阴性组,分析CD8+TIL与临床病理特征及生存期的关系。结果:乳腺癌标本中CD8+TIL阳性率为32.14%(36/112)。统计分析显示,CD8+TIL的表达在肿瘤分化程度、TNM分期及组织学分类的组间差异有统计学意义(χ2=6.277,P=0.043;χ2=3.963,P=0.047;χ2=4.299,P=0.038);CD8+TIL阳性组5年生存率明显高于CD8+TIL阴性组(88.89%vs.71.05%;χ2=4.360,P=0.037);Log-rank检验表明CD8+TIL阳性组总生存率明显高于CD8+TIL阴性组(P=0.043)。结论:乳腺癌组织CD8+TIL可以作为患者预后的指标,癌组织中CD8+TIL低密度浸润提示预后不良。
Objective: To investigate the relations of CD8+tumor-iniltrating lymphocytes(TILs) in breast cancer patients with their clinicopathologic features and survival outcomes. Methods: The CD8+TILs expression in embedded tissue sections from 122 breast cancer patients was detected by immunohistochemical staining. According to the CD8+TILs expression status, patients were divided into CD8+TILs positive group and CD8+TILs negative group, and the relations of CD8+TILs with clinicopathologic features and survival outcomes were analyzed. Results: Among the specimens, the positive rate of CD8+TILs expression was 32.14%(36/112). Statisticalanalysis showed that the differences in CD8+TILs expression had statistical significance between or among the groups divided by degree of diferentiation(χ2=6.277, P=0.043), TNM stage(χ2=3.963, P=0.047), and histological classiication(χ2=4.299, P=0.038). The 5-year survival of CD8+TILs positive group was significantly higher than that of CD8+TILs negative group(88.89% vs. 71.05%, χ2=4.360, P=0.037). Log-rank test showed that the overall survival of CD8+TILs positive group was significantly higher than that of CD8+ TILs negative group(P=0.043). Conclusion: CD8+TILs can be used as a prognostic index for breast cancer patients and low iniltration of CD8+TILs in tumor tissue may predict a poor outcome.
引文
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