摘要
免疫系统对抑制肿瘤的发生、发展具有重要作用,肿瘤细胞能被免疫细胞清除,故通过免疫系统消灭肿瘤细胞在治疗各种恶性肿瘤中显示出显著疗效。肿瘤细胞通过高表达CD_(47)与巨噬细胞表面的信号调节蛋白α相结合逃避机体的免疫监视,从而促进肿瘤的发展。因此,CD_(47)在肿瘤组织中的表达及抗CD_(47)抗体靶向免疫治疗成为研究热点。随着检测胃癌组织中CD_(47)的表达情况、开展体外胃癌细胞实验及动物模型实验、抗CD_(47)抗体等研究的深入,未来抗CD_(47)抗体用于胃癌免疫治疗将成为新途径。
The immune system plays an important role in inhibiting the occurrence and development of tumors,and tumor cells can be cleared by immune cells. Therefore,the elimination of tumor cells by the immune system shows a significant effect in the treatment of various malignant tumors. By highly expressing CD_(47),tumor cells combine with the signal regulatory protein α on the surface of macrophages to evade the immune surveillance of the body,thus promoting the development of tumors. Therefore,the expression of CD_(47) in tumor tissues and the targeted immunotherapy of anti-CD_(47) antibodies have become a research hotspot. With the deepening research on detecting the expression of CD_(47) in gastric cancer tissues,carrying out in vitro gastric cancer cell experiment,animal model experiment and anti-CD_(47) antibody,the application of antiCD_(47) antibody to immunotherapy for gastric cancer will become a new approach in the future.
引文
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