CD47在白血病干细胞中的表达及临床意义
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摘要
目的探讨CD47在白血病干细胞中的表达及临床意义。方法选取于2016年1月至2018年6月在我院血液科收住院的初诊急性白血病患者共48例,分析CD47表达阳性对急性白血病患者疗效的影响。结果各种分型表达阳性率分别与总病例表达阳性率对比,差异均无统计学意义(P> 0.05)。CD47表达阳性的治疗完全缓解率明显低于CD47表达阴性,差异具有统计学意义(P<0.05)。结论 CD47在急性白血病纯化白血病干细胞中表达或可作为判断急性白血病治疗疗效指标之一。
Objective To investigate CD47 expression in leukemic stem cells and its clinical significance.Methods Choose 48 cases newly diagnosed acute leukemia patients hospitalized in hematology department of our hospital from January 2016 to June 2018. Analyze effect of CD47 positive expression on curative effect of acute leukemia patients. Results Comparison difference between various types positive expression rate and total cases positive expression rate showed no statistical significance(P> 0.05). Complete remission rate of CD47 positive expression after treatment was significantly lower than CD47 negative expression, difference showed statistical significance(P< 0.05).Conclusion CD47 expression in purified leukemic stem cells of acute leukemia may be one of indicators of evaluating curative effect of acute leukemia.
Objective To investigate CD47 expression in leukemic stem cells and its clinical significance.Methods Choose 48 cases newly diagnosed acute leukemia patients hospitalized in hematology department of our hospital from January 2016 to June 2018. Analyze effect of CD47 positive expression on curative effect of acute leukemia patients. Results Comparison difference between various types positive expression rate and total cases positive expression rate showed no statistical significance(P> 0.05). Complete remission rate of CD47 positive expression after treatment was significantly lower than CD47 negative expression, difference showed statistical significance(P< 0.05).Conclusion CD47 expression in purified leukemic stem cells of acute leukemia may be one of indicators of evaluating curative effect of acute leukemia.
引文
[1]李婉红,陈葆国,郑瑞,等.CD47在急性髓细胞白血病干细胞中的表达及其临床意义探讨[J].医学研究杂志,2012,41(06):27-31
[2]顾宝罗,赵洪灿,范剑,等.CD47在急性髓细胞白血病干细胞中表达的临床意义[J].中华危重症医学杂志(电子版),2013,6(04):216-220.
[3]宋晓洁,冯伟平,韩雪娇,等.CD47在急性白血病干细胞中的表达及其对临床疗效及预后的影响[J].现代生物医学进展,2016,16(29):5760-5762+5796.
[4]吕心路,王金湖.CD123与CD47在急性髓细胞白血病干细胞中的表达及临床意义[J].浙江临床医学,2016,18(12):2188-2190.
[5]程海,曹江,陈伟,等.CD47在初诊正常核型急性髓系白血病患者中的表达及其临床意义[J].白血病·淋巴瘤,2017,26(11):670-674.
[6]刘春燕.CD47在急性髓细胞白血病中的表达及其疗效预后的关系[D].河北医科大学,2015.
[2]顾宝罗,赵洪灿,范剑,等.CD47在急性髓细胞白血病干细胞中表达的临床意义[J].中华危重症医学杂志(电子版),2013,6(04):216-220.
[3]宋晓洁,冯伟平,韩雪娇,等.CD47在急性白血病干细胞中的表达及其对临床疗效及预后的影响[J].现代生物医学进展,2016,16(29):5760-5762+5796.
[4]吕心路,王金湖.CD123与CD47在急性髓细胞白血病干细胞中的表达及临床意义[J].浙江临床医学,2016,18(12):2188-2190.
[5]程海,曹江,陈伟,等.CD47在初诊正常核型急性髓系白血病患者中的表达及其临床意义[J].白血病·淋巴瘤,2017,26(11):670-674.
[6]刘春燕.CD47在急性髓细胞白血病中的表达及其疗效预后的关系[D].河北医科大学,2015.