Correlation study of sleep efficiency with C-reactive protein and IL-6 in patients with infective endocarditis
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摘要
Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation. In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients. Methods A total of 117 post-operative patients with IE were enrolled in the study. All patients were tested using a wearable actigraphy device for their sleep efficiency. All patients were examined for C-reactive protein,and 72 patients were tested for IL-6. Results A correlation analysis was performed between C-reactive protein and IL-6. The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3 mg/L. The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011. The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543. Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.[S Chin J Cardiol2019;20(2):103-107]
Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation. In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients. Methods A total of 117 post-operative patients with IE were enrolled in the study. All patients were tested using a wearable actigraphy device for their sleep efficiency. All patients were examined for C-reactive protein,and 72 patients were tested for IL-6. Results A correlation analysis was performed between C-reactive protein and IL-6. The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3 mg/L. The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011. The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543. Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.[S Chin J Cardiol2019;20(2):103-107]
Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation. In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients. Methods A total of 117 post-operative patients with IE were enrolled in the study. All patients were tested using a wearable actigraphy device for their sleep efficiency. All patients were examined for C-reactive protein,and 72 patients were tested for IL-6. Results A correlation analysis was performed between C-reactive protein and IL-6. The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3 mg/L. The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011. The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543. Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.[S Chin J Cardiol2019;20(2):103-107]
引文
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8.Habib G,Lancellotti P,Antunes MJ,et al.2015 ESCguidelines for the management of infective endocarditis:the task force for the management of infective endocarditis of the European Society of Cardiology(ESC)endorsed by:European Association for Cardio-Thoracic Surgery(EACTS),the European Association of Nuclear Medicine(EANM).European heart journal 2015,36:3075-3128.
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12.Musiek ES,Xiong DD,Holtzman DM.Sleep,circadian rhythms,and the pathogenesis of Alzheimer disease.Experimental&molecular medicine 2015,47:e148.
13.Ridker PM,Rifai N,Stampfer MJ,et al.Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men.Circulation 2000,101:1767.
14.Dharmapalan D,Yewale V.C-reactive protein in pediatric infectious diseases.Pediatr Infect Dis J 2012,4:137-139.
15.Kim J,Lee SJ,Choi K-M,et al.Obstructive Sleep Apnea Is Associated with Elevated High Sensitivity C-Reactive Protein Levels Independent of Obesity:Korean Genome and Epidemiology Study.PLoS ONE 2016,11:e0163017
16.Popko K,Gorska E,Potapinska O,et al.Frequency of distribution of inflammatory cytokines IL-1,IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea.J Physiol Pharmacol 2008,59:607-614.
17.Van Leeuwen WMA,Lehto M,Karisola P,et al.Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP.PloS one 2009,4:e4589.
2.Petzoldt J,Wittchen HU,Einsle F,et al.Maternal anxiety versus depressive disorders:specific relations to infants.crying,feeding and sleeping problems.Child:care,health and development 2016,42:231-245.
3.Hla KM,Young T,Hagen EW,et al.Coronary heart disease incidence in sleep disordered breathing:the Wisconsin Sleep Cohort Study.Sleep 2015,38:677-684.
4.Irwin MR,Olmstead R,Carroll J E.Sleep disturbance,sleep duration,and inflammation:a systematic review and meta-analysis of cohort studies and experimental sleep deprivation.Biological psychiatry 2016,80:40-52.
5.Huang WY,Huang CC,Chang CC,et al.Associations of self-reported sleep quality with circulating interferon gamma-inducible protein 10,interleukin 6,and highsensitivity C-reactive protein in healthy menopausal women.PloS one 2017,12:e0169216.
6.Wong JK,Maxwell BG,Kushida CA,et al.Obstructive sleep apnea is an independent predictor of postoperative atrial fibrillation in cardiac surgery.Journal of cardiothoracic and vascular anesthesia 2015,29:1140-1147.
7.Baddour LM,Wilson WR,Bayer AS,et al.Infective endocarditis in adults:diagnosis,antimicrobial therapy,and management of complications:a scientific statement for healthcare professionals from the American Heart Association.Circulation 2015,132:1435-1486.
8.Habib G,Lancellotti P,Antunes MJ,et al.2015 ESCguidelines for the management of infective endocarditis:the task force for the management of infective endocarditis of the European Society of Cardiology(ESC)endorsed by:European Association for Cardio-Thoracic Surgery(EACTS),the European Association of Nuclear Medicine(EANM).European heart journal 2015,36:3075-3128.
9.Giri EP,Arymurthy AM,Fanany MI,et al.Sleep stages classification using shallow classifiers.2015 International Conference on Advanced Computer Science and Information Systems(ICACSIS).IEEE2015:297-301.
10.Powlson AS,Gurnell M.Cardiovascular disease and sleep-disordered breathing in acromegaly.Neuroendocrinology 2016,103:75-85.
11.Ju YES,Finn MB,Sutphen CL,et al.Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.Annals of neurology 2016,80:154-159.
12.Musiek ES,Xiong DD,Holtzman DM.Sleep,circadian rhythms,and the pathogenesis of Alzheimer disease.Experimental&molecular medicine 2015,47:e148.
13.Ridker PM,Rifai N,Stampfer MJ,et al.Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men.Circulation 2000,101:1767.
14.Dharmapalan D,Yewale V.C-reactive protein in pediatric infectious diseases.Pediatr Infect Dis J 2012,4:137-139.
15.Kim J,Lee SJ,Choi K-M,et al.Obstructive Sleep Apnea Is Associated with Elevated High Sensitivity C-Reactive Protein Levels Independent of Obesity:Korean Genome and Epidemiology Study.PLoS ONE 2016,11:e0163017
16.Popko K,Gorska E,Potapinska O,et al.Frequency of distribution of inflammatory cytokines IL-1,IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea.J Physiol Pharmacol 2008,59:607-614.
17.Van Leeuwen WMA,Lehto M,Karisola P,et al.Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP.PloS one 2009,4:e4589.