咖啡因对支气管肺发育不良的预防作用研究进展
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摘要
支气管肺发育不良(BPD)是严重威胁早产儿健康的慢性肺部疾病,其致病机制及风险因素众多,临床缺乏理想的防治措施。咖啡因是当前临床BPD防治的一线药物,可降低BPD发病率并改善病情严重程度,但咖啡因具体作用机制并不明确。近期研究发现,咖啡因可抑制多种BPD风险因素并促进肺成熟。文章综述咖啡因预防BPD的相关研究成果。
Bronchopulmonary dysplasia(BPD) is a chronic lung disease and it seriously threatens the health of premature infants. Its pathogenic mechanism and risk factors are numerous. There is lack of ideal prevention and treatment in clinic.Caffeine clinically is the first line of prevention and treatment for BPD and it can reduce the incidence of BPD and improve the severity of the disease. But the specific mechanism of caffeine is not clear. Recent studies have found that caffeine inhibits a variety of BPD risk factors and promotes lung maturation. This article reviews the related research of caffeine in preventing BPD.
Bronchopulmonary dysplasia(BPD) is a chronic lung disease and it seriously threatens the health of premature infants. Its pathogenic mechanism and risk factors are numerous. There is lack of ideal prevention and treatment in clinic.Caffeine clinically is the first line of prevention and treatment for BPD and it can reduce the incidence of BPD and improve the severity of the disease. But the specific mechanism of caffeine is not clear. Recent studies have found that caffeine inhibits a variety of BPD risk factors and promotes lung maturation. This article reviews the related research of caffeine in preventing BPD.
引文
[1]Davidson LM,Berkelhamer SK.Bronchopulmonary dysplasia:chronic lung disease of infancy and long-term pulmonary outcomes[J].J Clin Med,2017,6(1).pii:E4.doi:10.3390/jcm6010004.
[2]Rutkowska M,Hozejowski R,Helwich E,et al.Severe bronchopulmonary dysplasia-incidence and predictive factors in a prospective,multicenter study in very preterm infants with respiratory distress syndrome[J].J Matern Fetal Neonatal Med,2019,32(12):1958-1964.
[3]吉玲,冯姝华,杨赟,等.不同胎龄早产儿支气管肺发育不良发生率及肺功能分析[J].临床儿科杂志,2018,36(7):505-509
[4]Choi EK,Jung YH,Kim HS,et al.The impact of atrial leftto-right shunt on pulmonary hypertension in preterm infants with moderate or severe bronchopulmonary dysplasia[J].Pediatr Neonatol,2015,56(5):317-323.
[5]Cheong JL,Burnett AC,Lee KJ,et al.Association between postnatal dexamethasone for treatment of bronchopulmonary dysplasia and brain volumes at adolescence in infants born very preterm[J].J Pediatr,2014,164(4):737-743.
[6]Shah SS,Ohlsson A,Halliday HL,et al.Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates[J].Cochrane Database Syst Rev,2017,10:CD002058.
[7]Schmidt B,Roberts RS,Davis P,et al.Caffeine therapy for apnea of prematurity[J].N Engl J Med,2006,354(20):2112-2121.
[8]Schmidt B,Roberts RS,Davis P,et al.Long-term effects of caffeine therapy for apnea of prematurity[J].N Engl J Med,2007,357(19):1893-1902.
[9]陈静,陈晓,龚放.不同维持剂量枸橼酸咖啡因治疗早产儿呼吸暂停疗效和安全性的meta分析[J].临床儿科杂志,2018,36(9):697-701.
[10]张丹,邵玉,富建华,等.咖啡因在极/超低出生体重早产儿机械通气撤机中应用的临床疗效[J].中华新生儿科杂志,2018,33(4):254-257.
[11]Eichenwald EC;Committee on Fetus and Newborn,American Academy of Pediatrics.Apnea of prematurity[J].Pediatrics,2016,137(1):e20153757.doi:10.1542/peds.2015-3757.
[12]Brattstr?m P,Russo C,Ley D,et al.High-versus low-dose caffeine in preterm infants:a systematic review and metaanalysis[J].Acta Paediatr,2019,108(3):401-410.
[13]Shenk EE,Bondi DS,Pellerite MM,et al.Evaluation of timing and dosing of caffeine citrate in preterm neonates for the prevention of bronchopulmonary dysplasia[J].J Pediatr Pharmacol Ther,2018,23(2):139-145.
[14]Jensen EA,DeMauro SB,Kornhauser M,et al.Effects of multiple ventilation courses and duration of mechanical ventilation on respiratory outcomes in extremely low-birthweight infants[J].JAMA Pediatr,2015,169(11):1011-1017.
[15]Shabir A,Hooton A,Tallis J,et al.The influence of caffeine expectancies on sport,exercise,and cognitive performance[J].Nutrients,2018,10(10).pii:E1528.doi:10.3390/nu10101528.
[16]Borszewska-Kornacka MK,Hozejowski R,Rutkowska M,et al.Shifting the boundaries for early caffeine initiation in neonatal practice:results of a prospective,multicenter study on very preterm infants with respiratory distress syndrome[J].PLo S One,2017,12(12):e0189152.
[17]Ferguson KN,Roberts CT,Manley BJ,et al.Interventions to improve rates of successful extubation in preterm infants:a systematic review and meta-analysis[J].JAMA Pediatr,2017,171(2):165-174.
[18]Han T,Chi M,Wang Y,et al.Therapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice[J].Am J Transl Res,2017,9(8):3528-3540.
[19]Hummler JK,Dapaah-Siakwan F,Vaidya R,et al.Inhibition of Rac1 signaling downregulates inflammasome activation and attenuates lung injury in neonatal rats exposed to hyperoxia[J].Neonatology,2017,111(3):280-288.
[20]Hwang JH,Kim KJ,Ryu SJ,et al.Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish[J].Chem Biol Interact,2016,248:1-7.
[21]K?ro?lu OA,MacFarlane PM,Balan KV,et al.Antiinflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis[J].Neonatology,2014,106(3):235-240.
[22]Nagatomo T,Jimenez J,Richter J,et al.Caffeine prevents hyperoxia-induced functional and structural lung damage in preterm rabbits[J].Neonatology,2016,109(4):274-281.
[23]Jin M,Lee J,Lee KY,et al.Alteration of TGF-beta-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats[J].Exp Lung Res,2016,42(7):354-364.
[24]Oak P,Pritzke T,Thiel I,et al.Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease[J].EMBO Mol Med,2017,9(11):1504-1520.
[25]Fehrholz M,Speer CP,Kunzmann S.Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells[J].PLoS One,2014,9(5):e97357.
[26]Tatler AL,Barnes J,Habgood A,et al.Caffeine inhibits TGFbeta activation in epithelial cells,interrupts fibroblast responses to TGFbeta,and reduces established fibrosis in ex vivo precision-cut lung slices[J].Thorax,2016,71(6):565-567.
[27]Dumpa V,Bhandari V.Surfactant,steroids and non-invasive ventilation in the prevention of BPD[J].Semin Perinatol,2018,42(7):444-452.
[28]Pan J,Zhan C,Yuan T,et al.Effects and molecular mechanisms of intrauterine infection/inflammation on lung development[J].Respir Res,2018,19(1):93.
[29]Li L,Yang C,Feng X,et al.Effects of intratracheal budesonide during early postnatal life on lung maturity of premature fetal rabbits[J].Pediatr Pulmonol,2018,53(1):28-35.
[30]Fehrholz M,Hutten M,Kramer BW,et al.Amplification of steroid-mediated SP-B expression by physiological levels of caffeine[J].Am J Physiol Lung Cell Mol Physiol,2014,306(1):L101-L109.
[2]Rutkowska M,Hozejowski R,Helwich E,et al.Severe bronchopulmonary dysplasia-incidence and predictive factors in a prospective,multicenter study in very preterm infants with respiratory distress syndrome[J].J Matern Fetal Neonatal Med,2019,32(12):1958-1964.
[3]吉玲,冯姝华,杨赟,等.不同胎龄早产儿支气管肺发育不良发生率及肺功能分析[J].临床儿科杂志,2018,36(7):505-509
[4]Choi EK,Jung YH,Kim HS,et al.The impact of atrial leftto-right shunt on pulmonary hypertension in preterm infants with moderate or severe bronchopulmonary dysplasia[J].Pediatr Neonatol,2015,56(5):317-323.
[5]Cheong JL,Burnett AC,Lee KJ,et al.Association between postnatal dexamethasone for treatment of bronchopulmonary dysplasia and brain volumes at adolescence in infants born very preterm[J].J Pediatr,2014,164(4):737-743.
[6]Shah SS,Ohlsson A,Halliday HL,et al.Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates[J].Cochrane Database Syst Rev,2017,10:CD002058.
[7]Schmidt B,Roberts RS,Davis P,et al.Caffeine therapy for apnea of prematurity[J].N Engl J Med,2006,354(20):2112-2121.
[8]Schmidt B,Roberts RS,Davis P,et al.Long-term effects of caffeine therapy for apnea of prematurity[J].N Engl J Med,2007,357(19):1893-1902.
[9]陈静,陈晓,龚放.不同维持剂量枸橼酸咖啡因治疗早产儿呼吸暂停疗效和安全性的meta分析[J].临床儿科杂志,2018,36(9):697-701.
[10]张丹,邵玉,富建华,等.咖啡因在极/超低出生体重早产儿机械通气撤机中应用的临床疗效[J].中华新生儿科杂志,2018,33(4):254-257.
[11]Eichenwald EC;Committee on Fetus and Newborn,American Academy of Pediatrics.Apnea of prematurity[J].Pediatrics,2016,137(1):e20153757.doi:10.1542/peds.2015-3757.
[12]Brattstr?m P,Russo C,Ley D,et al.High-versus low-dose caffeine in preterm infants:a systematic review and metaanalysis[J].Acta Paediatr,2019,108(3):401-410.
[13]Shenk EE,Bondi DS,Pellerite MM,et al.Evaluation of timing and dosing of caffeine citrate in preterm neonates for the prevention of bronchopulmonary dysplasia[J].J Pediatr Pharmacol Ther,2018,23(2):139-145.
[14]Jensen EA,DeMauro SB,Kornhauser M,et al.Effects of multiple ventilation courses and duration of mechanical ventilation on respiratory outcomes in extremely low-birthweight infants[J].JAMA Pediatr,2015,169(11):1011-1017.
[15]Shabir A,Hooton A,Tallis J,et al.The influence of caffeine expectancies on sport,exercise,and cognitive performance[J].Nutrients,2018,10(10).pii:E1528.doi:10.3390/nu10101528.
[16]Borszewska-Kornacka MK,Hozejowski R,Rutkowska M,et al.Shifting the boundaries for early caffeine initiation in neonatal practice:results of a prospective,multicenter study on very preterm infants with respiratory distress syndrome[J].PLo S One,2017,12(12):e0189152.
[17]Ferguson KN,Roberts CT,Manley BJ,et al.Interventions to improve rates of successful extubation in preterm infants:a systematic review and meta-analysis[J].JAMA Pediatr,2017,171(2):165-174.
[18]Han T,Chi M,Wang Y,et al.Therapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice[J].Am J Transl Res,2017,9(8):3528-3540.
[19]Hummler JK,Dapaah-Siakwan F,Vaidya R,et al.Inhibition of Rac1 signaling downregulates inflammasome activation and attenuates lung injury in neonatal rats exposed to hyperoxia[J].Neonatology,2017,111(3):280-288.
[20]Hwang JH,Kim KJ,Ryu SJ,et al.Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish[J].Chem Biol Interact,2016,248:1-7.
[21]K?ro?lu OA,MacFarlane PM,Balan KV,et al.Antiinflammatory effect of caffeine is associated with improved lung function after lipopolysaccharide-induced amnionitis[J].Neonatology,2014,106(3):235-240.
[22]Nagatomo T,Jimenez J,Richter J,et al.Caffeine prevents hyperoxia-induced functional and structural lung damage in preterm rabbits[J].Neonatology,2016,109(4):274-281.
[23]Jin M,Lee J,Lee KY,et al.Alteration of TGF-beta-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats[J].Exp Lung Res,2016,42(7):354-364.
[24]Oak P,Pritzke T,Thiel I,et al.Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease[J].EMBO Mol Med,2017,9(11):1504-1520.
[25]Fehrholz M,Speer CP,Kunzmann S.Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells[J].PLoS One,2014,9(5):e97357.
[26]Tatler AL,Barnes J,Habgood A,et al.Caffeine inhibits TGFbeta activation in epithelial cells,interrupts fibroblast responses to TGFbeta,and reduces established fibrosis in ex vivo precision-cut lung slices[J].Thorax,2016,71(6):565-567.
[27]Dumpa V,Bhandari V.Surfactant,steroids and non-invasive ventilation in the prevention of BPD[J].Semin Perinatol,2018,42(7):444-452.
[28]Pan J,Zhan C,Yuan T,et al.Effects and molecular mechanisms of intrauterine infection/inflammation on lung development[J].Respir Res,2018,19(1):93.
[29]Li L,Yang C,Feng X,et al.Effects of intratracheal budesonide during early postnatal life on lung maturity of premature fetal rabbits[J].Pediatr Pulmonol,2018,53(1):28-35.
[30]Fehrholz M,Hutten M,Kramer BW,et al.Amplification of steroid-mediated SP-B expression by physiological levels of caffeine[J].Am J Physiol Lung Cell Mol Physiol,2014,306(1):L101-L109.