小胶质细胞M1/M2极化状态在脊髓损伤中作用的研究进展
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摘要
<正>脊髓损伤(SCI)是指由创伤、肿瘤、感染、畸形和医源性等因素引起的脊髓结构或功能受损,严重影响患者生活质量、功能状态和社会独立性。SCI发生后常会出现出血、局部休克、缺氧、三磷酸腺苷减少、小胶质细胞激活和促炎性细胞因子释放等。中国SCI发生率为15～60/百万,且呈逐年升高趋势~([1])。及时有效的治疗将会大幅提高SCI患者生活质量。按照病理发生过程,SCI可分为原发性损
引文
[1]L Ramos T,Sánchez-Abarca LI,Muntión S,et al.MSC surface markers(CD44,CD73,and CD90)can identify human MSC-derived extracellular vesicles by conventional flow cytometry[J].Cell Commun Signal,2016,14:2.
[2]Anwar MA,Al Shehabi TS,Eid AH.Inflammogenesis of secondary spinal cord injury[J].Front Cell Neurosci,2016,10:98.
[3]李洪秋,王哲,阿良.骨髓间充质干细胞移植对大鼠脊髓损伤后氧化应激的影响[J].脊柱外科杂志,2010,8(3):157-161.
[4]Papa S,Ferrari R,De Paola M,et al.Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury[J].J Control Release,2014,174:15-26.
[5]Lim H,Lee H,Noh K,et al.IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury[J].Pain,2017,158(9):1666-1677.
[6]吴海歌,刘雨晴,姚子昂.小胶质细胞及相关神经退行性疾病[J].中国细胞生物学学报,2015,37(4):560-564.
[7]Gensel JC,Zhang B.Macrophage activation and its role in repair and pathology after spinal cord injury[J].Brain Res,2015,1619:1-11.
[8]Saxena T,Loomis KH,Pai SB,et al.Nanocarriermediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury[J].ACS Nano,2015,9(2):1492-1505.
[9]Lee JH,Wei ZZ,Cao W,et al.Regulation of therapeutic hypothermia on inflammatory cytokines,microglia polarization,migration and functional recovery after ischemic stroke in mice[J].Neurobiol Dis,2016,96:248-260.
[10]Orihuela R,McPherson CA,Harry GJ.Microglial M1/M2 polarization and metabolic states[J].Br JPharmacol,2016,173(4):649-665.
[11]Cerqueira SR,Oliveira JM,Silva NA,et al.Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury[J].Small,2013,9(5):738-749.
[12]Aceves M,Terminel MN,Okoreeh A,et al.Morphine increases macrophages at the lesion site following spinal cord injury:protective effects of minocycline[J].Brain Behav Immun,2019,23:10.1016/j.bbi.2019.01.023.[Epub ahead of print]
[13]Lu L,Barfejani AH,Qin T,et al.Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage[J].Brain Res,2014,1555:89-96.
[14]Kim K,Park HW,Moon HE,et al.The effect of human umbilical cord blood-derived mesenchymal stem cells in a collagenase-induced intracerebral hemorrhage rat model[J].Exp Neurobiol,2015,24(2):146-155.
[15]Yu Z,Tang L,Chen L,et al.Erythropoietin reduces brain injury after intracerebral hemorrhagic stroke in rats[J].Mol Med Rep,2013,8(5):1315-1322.
[16]Lan X,Han X,Li Q,et al.Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia[J].Brain Behav Immun,2017,61:326-339.
[17]Wang YC,Wang PF,Fang H,et al.Toll-like receptor 4antagonist attenuates intracerebral hemorrhage-induced brain injury[J].Stroke,2013,44(9):2545-2552.
[18]Shi H,Wang J,Wang J,et al.IL-17A induces autophagy and promotes microglial neuroinflammation through ATG5 and ATG7 in intracerebral hemorrhage[J].J Neuroimmunol,2018,323:143-151.
[19]Wu HY,Tang XQ,Liu H,et al.Both classic Gs-c AMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREBsignal pathways mediate exenatide-stimulated expression of M2 microglial markers[J].J Neuroimmunol,2018,316:17-22.
[20]Kata D,F?ldesi I,Feher LZ,et al.Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells[J].Neuroscience,2016,314:47-63.
[21]Shi H,Zheng K,Su Z,et al.Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage[J].J Neuroimmunol,2016,299:28-34.
[22]Han D,Yu Z,Liu W,et al.Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state[J].Cell Death Dis,2018,9(2):181.
[23]Lu Q,Gao L,Huang L,et al.Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat[J].J Neuroinflammation,2014,11:44.
[24]Bukhari SN,Lauro G,Jantan I,et al.Anti-inflammatory trends of new benzimidazole derivatives[J].Future Med Chem,2016,8(16):1953-1967.
[25]Liang D,Zuo A,Shao H,et al.Anti-inflammatory or proinflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environment-dependent[J].J Immunol,2014,193(11):5498-5505.
[26]Allard D,Allard B,Gaudreau PO,et al.CD73-adenosine:a next-generation target in immuno-oncology[J].Immunotherapy,2016,8(2):145-163.
[27]Zhou HJ,Wang LQ,Xu QS,et al.Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells[J].Exp Cell Res,2016,349(1):60-67.
[28]Srivastava IN,Shperdheja J,Baybis M,et al.mTORpathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy[J].Neurobiol Dis,2016,85:144-154.
[29]闫廷飞,孙璟川,孙晨曦,等.脊神经结扎术后脊髓背角小胶质细胞中miR-195的表达及其对自噬水平的影响[J].中国脊柱脊髓杂志,2017,27(11):1030-1036.
[2]Anwar MA,Al Shehabi TS,Eid AH.Inflammogenesis of secondary spinal cord injury[J].Front Cell Neurosci,2016,10:98.
[3]李洪秋,王哲,阿良.骨髓间充质干细胞移植对大鼠脊髓损伤后氧化应激的影响[J].脊柱外科杂志,2010,8(3):157-161.
[4]Papa S,Ferrari R,De Paola M,et al.Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury[J].J Control Release,2014,174:15-26.
[5]Lim H,Lee H,Noh K,et al.IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury[J].Pain,2017,158(9):1666-1677.
[6]吴海歌,刘雨晴,姚子昂.小胶质细胞及相关神经退行性疾病[J].中国细胞生物学学报,2015,37(4):560-564.
[7]Gensel JC,Zhang B.Macrophage activation and its role in repair and pathology after spinal cord injury[J].Brain Res,2015,1619:1-11.
[8]Saxena T,Loomis KH,Pai SB,et al.Nanocarriermediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury[J].ACS Nano,2015,9(2):1492-1505.
[9]Lee JH,Wei ZZ,Cao W,et al.Regulation of therapeutic hypothermia on inflammatory cytokines,microglia polarization,migration and functional recovery after ischemic stroke in mice[J].Neurobiol Dis,2016,96:248-260.
[10]Orihuela R,McPherson CA,Harry GJ.Microglial M1/M2 polarization and metabolic states[J].Br JPharmacol,2016,173(4):649-665.
[11]Cerqueira SR,Oliveira JM,Silva NA,et al.Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury[J].Small,2013,9(5):738-749.
[12]Aceves M,Terminel MN,Okoreeh A,et al.Morphine increases macrophages at the lesion site following spinal cord injury:protective effects of minocycline[J].Brain Behav Immun,2019,23:10.1016/j.bbi.2019.01.023.[Epub ahead of print]
[13]Lu L,Barfejani AH,Qin T,et al.Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage[J].Brain Res,2014,1555:89-96.
[14]Kim K,Park HW,Moon HE,et al.The effect of human umbilical cord blood-derived mesenchymal stem cells in a collagenase-induced intracerebral hemorrhage rat model[J].Exp Neurobiol,2015,24(2):146-155.
[15]Yu Z,Tang L,Chen L,et al.Erythropoietin reduces brain injury after intracerebral hemorrhagic stroke in rats[J].Mol Med Rep,2013,8(5):1315-1322.
[16]Lan X,Han X,Li Q,et al.Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia[J].Brain Behav Immun,2017,61:326-339.
[17]Wang YC,Wang PF,Fang H,et al.Toll-like receptor 4antagonist attenuates intracerebral hemorrhage-induced brain injury[J].Stroke,2013,44(9):2545-2552.
[18]Shi H,Wang J,Wang J,et al.IL-17A induces autophagy and promotes microglial neuroinflammation through ATG5 and ATG7 in intracerebral hemorrhage[J].J Neuroimmunol,2018,323:143-151.
[19]Wu HY,Tang XQ,Liu H,et al.Both classic Gs-c AMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREBsignal pathways mediate exenatide-stimulated expression of M2 microglial markers[J].J Neuroimmunol,2018,316:17-22.
[20]Kata D,F?ldesi I,Feher LZ,et al.Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells[J].Neuroscience,2016,314:47-63.
[21]Shi H,Zheng K,Su Z,et al.Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage[J].J Neuroimmunol,2016,299:28-34.
[22]Han D,Yu Z,Liu W,et al.Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state[J].Cell Death Dis,2018,9(2):181.
[23]Lu Q,Gao L,Huang L,et al.Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat[J].J Neuroinflammation,2014,11:44.
[24]Bukhari SN,Lauro G,Jantan I,et al.Anti-inflammatory trends of new benzimidazole derivatives[J].Future Med Chem,2016,8(16):1953-1967.
[25]Liang D,Zuo A,Shao H,et al.Anti-inflammatory or proinflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environment-dependent[J].J Immunol,2014,193(11):5498-5505.
[26]Allard D,Allard B,Gaudreau PO,et al.CD73-adenosine:a next-generation target in immuno-oncology[J].Immunotherapy,2016,8(2):145-163.
[27]Zhou HJ,Wang LQ,Xu QS,et al.Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells[J].Exp Cell Res,2016,349(1):60-67.
[28]Srivastava IN,Shperdheja J,Baybis M,et al.mTORpathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy[J].Neurobiol Dis,2016,85:144-154.
[29]闫廷飞,孙璟川,孙晨曦,等.脊神经结扎术后脊髓背角小胶质细胞中miR-195的表达及其对自噬水平的影响[J].中国脊柱脊髓杂志,2017,27(11):1030-1036.