MIF在急性心肌缺血再灌注期间的变化及其意义
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摘要
目的探讨巨噬细胞移动抑制因子MIF在急性心肌梗死患者行PCI再灌注治疗期间的变化及其意义。方法选择2017年12月—2018年12月因"急性心肌梗死"在佳木斯大学附属第一医院住院的48例患者作为实验组,其中设急诊PCI组28例(≤12 h),择期PCI组20例(3～7 d)。两组患者分别在术中取鞘管内动脉血,术后(12 h)抽取肘静脉血,采用酶联免疫吸附(ELISA)法测定血清MIF水平。另外,随机选取同期稳定型心绞痛患者20例(SAP组)和20名健康体检者(健康组)作为对照组。结果急诊PCI组术前MIF水平和择期PCI组术前MIF水平均明显高于对照组SAP组和健康组,均为P<0.01;急诊PCI术前MIF水平与急诊PCI组术后MIF水平比较,差异有统计学意义(P<0.01),且呈正相关(r=0.676,P<0.01)。择期PCI术前MIF水平与择期PCI术后MIF水平比较,差异有统计学意义(P<0.01)且呈正相关(r=0.548,P<0.01);急诊PCI组MIF水平同冠脉Gensini评分呈正相关(r=0.388,P<0.05),择期PCI组MIF水平同冠脉Gensini评分呈正相关(r=0.553,P<0.05)。结论在急性心肌梗死时MIF水平明显上升,并与冠脉病变程度相关,可作为反应心肌缺血程度的预测因子。
引文
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[7]邓湘宁,王新宇,于海奕,等.急性心肌梗死患者血巨噬细胞移动抑制因子的变化及临床意义[J].中国心血管杂志,2018,23(2):104-109.
[2] Mtiller II,Miiller K,Sch9nleber H,et al. Maerophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response[J]. PLoS One,2012,7(6):e38376.
[3] Day awansa NH,Gao XM,White DA,et al. Role of MIF in myocardial ischaemia and infarction:insight from recent clinical and experimental findings[J].Clin Sci,2014,127:149-161.
[4] Koga K,Kenessey A,Powell SR,et al. Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusionby reducing oxidative stress[J]. Antioxid Redox Signal,2011,14:1191-1202.
[5] Stoppe C,Rex S,Goetzenich A,et al. Interaction of MIF family proteins in myocardial ischemia/reperfusion damage and their influence on clinical outcome of cardiac surgery patients[J].Antioxid Redox Signal,2015,23(11):865-879.
[6]靳祺.GDF-15、MIF、F1+2在冠心病患者中的表达及PCI干预对其影响和临床意义[D].遵义医学院,2013.
[7]邓湘宁,王新宇,于海奕,等.急性心肌梗死患者血巨噬细胞移动抑制因子的变化及临床意义[J].中国心血管杂志,2018,23(2):104-109.