血清硫氧还蛋白1与脑外伤患者的白质恢复的相关性分析
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摘要
为探讨血清硫氧还蛋白1 (thioredoxin 1, Trx1)含量与脑外伤后白质恢复的相关性关系,本研究选取60例脑外伤患者,根据格拉斯哥昏迷指数(Glasgow coma scale, GCS)将患者分为3组(轻度,中度和重度脑外伤患者),每组20例,采用核磁共振成像(magnetic resonance imaging, MRI)检测各组患者头颅白质情况,并通过ELISA方法检测各组患者血清Trx1水平,最后利用SPSS软件Pearson方法检测血清硫氧还蛋白1含量与脑外伤后白质恢复的相关性。结果显示,轻度脑损伤患者的GCS分值明显高于中度和重度脑外伤患者;轻度脑外伤患者的Trx1含量明显高于中度和重度患者;轻度和中度脑外伤患者的白质恢复情况明显优于重度患者;脑损伤患者的血清Trx1含量和白质恢复程度呈正相关。本研究初步结论表明脑外伤患者的白质恢复情况与血清Trx1存在正相关性关系,这将为脑外伤的治疗提供新思路。
In order to explore the correlation between serum thioredoxin 1(Trx1) and the recovery of white matter after traumatic brain injury, sixty patients with brain injury were divided into three groups(light, moderate,severe group) according to Glasgow coma scale(GCS) with 20 patients in each group in this research. Magnetic resonance imaging(MRI) was used to detect the white matter in each group. ELISA was used to detect serum Trx1 level in each group. Correlation between serum thioredoxin-1 and recovery of white matter after brain injury by SPSS software. The results showed that the GCS score of patients with mild brain injury was significantly higher than that of moderate and severe brain injury patients. The level of Trx1 in patients with mild brain injury was significantly higher than that in moderate and severe patients. The recovery of white matter in mild and moderate brain injury patients was significantly better than that in severe patients. There was a positive correlation between the serum Trx1 level and the recovery of white matter in patients with brain injury. The preliminary conclusions of this study indicate that there is a positive correlation between the recovery of white matter and serum Trx1 in patients with brain injury, which will provide new ideas for the treatment of brain injury.
In order to explore the correlation between serum thioredoxin 1(Trx1) and the recovery of white matter after traumatic brain injury, sixty patients with brain injury were divided into three groups(light, moderate,severe group) according to Glasgow coma scale(GCS) with 20 patients in each group in this research. Magnetic resonance imaging(MRI) was used to detect the white matter in each group. ELISA was used to detect serum Trx1 level in each group. Correlation between serum thioredoxin-1 and recovery of white matter after brain injury by SPSS software. The results showed that the GCS score of patients with mild brain injury was significantly higher than that of moderate and severe brain injury patients. The level of Trx1 in patients with mild brain injury was significantly higher than that in moderate and severe patients. The recovery of white matter in mild and moderate brain injury patients was significantly better than that in severe patients. There was a positive correlation between the serum Trx1 level and the recovery of white matter in patients with brain injury. The preliminary conclusions of this study indicate that there is a positive correlation between the recovery of white matter and serum Trx1 in patients with brain injury, which will provide new ideas for the treatment of brain injury.
引文
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Ogunlade J.,Elia C.,Duong J.,Yanez P.J.,Dong F.L.,Wacker M.R.,Menoi R.,Goldenberg T.,and Miulli D.E.,2018,Severe traumatic brain injury requiring surgical decompression in the young adult:factors influencing morbidity and mortality-a retrospective analysis,Cureus,10(7):e3042
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Virzi G.M.,Breglia A.,Brocca A.,Bolin C.,Vescovo G.,and Ronco C.,2018,Levels of proinflammatory cytokines,oxidative stress,and tissue damage markers in patients with acute heart failure with and without cardiorenal syndrome type 1,Cardiorenal Medicine,8(4):321-331
Wang B.,Tian S.,Wang J.,Han F.,Zhao L.,Wang R.,Ning W.,Chen W.,and Qu Y.,2015,Intraperitoneal administration of thioredoxin decreases brain damage from ischemic stroke,Brain.Res.,1615:89-97
Xiong K.,Zhu Y.,Zhang Y.,Yin Z.,Zhang J.,Qiu M.,and Zhang W.,2014,White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident,Brain.Res.,1591:86-92
Zuo H.,Yuan J.,Yang L.W.,Liang Z.W.,Weng S.P.,He J.G.,and Xu X.P.,2018,Characterization and immune function of the thioredoxin-interacting protein(TXNIP)from Litopenaeus vannamei,Fish Shellfish Immunol,84:20-27
Zhang L.,Zhu J.H.,Zhang X.,and Cheng W.H.,2018,The thioredoxin-like family of selenoproteins:implications in aging and age-related degeneration,Biological Trace Elem.Res.,188:189-195
Hogan R.E.,2018,Epileptic seizures,brain volume changes,and“brain damage”:What do we know so far,Epilepsy.Curr.18(4):224-226
Lee S.J.,Tran N.Q.,Lee J.,and Richardson C.C.,2018,Hydrophobic residue in escherichia coli thioredoxin critical for the processivity of T7 DNA polymerase,Biochemistry,57(40):5807-5817
Mierzwa A.J.,Marion C.M.,Sullivan G.M.,McDaniel D.P.,and Armstrong R.C.,2015,Components of myelin damage and repair in the progressio n of white matter pathology after mild traumatic brain injury,J.Neuropathol.Exp.Neurol.,74(3):218-232
Ogunlade J.,Elia C.,Duong J.,Yanez P.J.,Dong F.L.,Wacker M.R.,Menoi R.,Goldenberg T.,and Miulli D.E.,2018,Severe traumatic brain injury requiring surgical decompression in the young adult:factors influencing morbidity and mortality-a retrospective analysis,Cureus,10(7):e3042
Rumalla K.,Smith K.A.,Letchuman V.,Gandham M.,Kombathula R.,and Arnold P.M.,2018,Nationwide incidence and risk factors for posttraumatic seizures in children with traumatic brain injury,Journal of Neurosurgery Pediatrics,22(6):684-693
Romano A.,Moraschi M.,Cornia R.,Bozzao A.,Rossi-Espagnet M.C.,Giove F.,Albertini G.,and Pierallini A.,2018,White matter involvement in young non-demented Down's syndrome subjects:a tract-based spatial statistic analysis,Neuroradiology,60(12):1335-1341
Virzi G.M.,Breglia A.,Brocca A.,Bolin C.,Vescovo G.,and Ronco C.,2018,Levels of proinflammatory cytokines,oxidative stress,and tissue damage markers in patients with acute heart failure with and without cardiorenal syndrome type 1,Cardiorenal Medicine,8(4):321-331
Wang B.,Tian S.,Wang J.,Han F.,Zhao L.,Wang R.,Ning W.,Chen W.,and Qu Y.,2015,Intraperitoneal administration of thioredoxin decreases brain damage from ischemic stroke,Brain.Res.,1615:89-97
Xiong K.,Zhu Y.,Zhang Y.,Yin Z.,Zhang J.,Qiu M.,and Zhang W.,2014,White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident,Brain.Res.,1591:86-92
Zuo H.,Yuan J.,Yang L.W.,Liang Z.W.,Weng S.P.,He J.G.,and Xu X.P.,2018,Characterization and immune function of the thioredoxin-interacting protein(TXNIP)from Litopenaeus vannamei,Fish Shellfish Immunol,84:20-27
Zhang L.,Zhu J.H.,Zhang X.,and Cheng W.H.,2018,The thioredoxin-like family of selenoproteins:implications in aging and age-related degeneration,Biological Trace Elem.Res.,188:189-195