多奈哌齐治疗阿尔茨海默病的临床疗效及对患者炎性因子的影响
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摘要
目的探讨阿尔茨海默病采用多奈哌齐治疗的临床疗效及对患者炎性因子的影响。方法纳入该院2016年3月—2018年3月精神科收治的90例阿尔茨海默病患者,按照随机数字表法均分为两组,各45例,对照组给予常规治疗,观察组在常规治疗基础上加以多奈哌齐治疗,比较两组临床疗效、治疗前后简易智能精神状态检查量表(MMSE)评分、血清IL-1β、TNF-α、IL-6水平。结果观察组治疗显效率和总有效率均较对照组显著提高62.22%vs 40.00%,95.56%vs 77.27%)(χ~2=9.684、16.368,P<0.05);观察组治疗后的MMSE评分为(20.35±2.21)分,较对照组的(18.61±2.18)分显著提高(t=3.545,P<0.05);观察组治疗后的血清IL-1β、TNF-α、IL-6水平分别为(1.79±0.33)ng/L (1.20±0.13)μg/L、(8.20±1.21)ng/L,均显著低于对照组的(2.21±0.37)ng/L、(1.75±0.30)μg/L、(11.21±1.19)ng/L(t=5.358、11.284、11.898,P<0.05)。结论对于阿尔茨海默病患者,给予多奈哌齐治疗效果确切,改善认知功能功能,降低炎性反应。
Objective To investigate the clinical efficacy of treatment with donepezil in Alzheimer's disease and its effect on inflammatory factors in patients. Methods A total of 90 patients with Alzheimer's disease admitted to our department from March 2016 to March 2018 in our hospital were divided into two groups according to the random number table, 45 cases in each group. The control group received routine treatment. The observation group was on the basis of conventional treatment added donepezil, compared the clinical efficacy, the simple intelligent mental state examination scale(MMSE) score before and after treatment, serum IL-1β, TNF-α, and IL-6 levels were compared. Results The effective rate and total effective rate of the observation group were significantly higher than those of the control group(62.22% vs 40.00%, 95.56% vs 77.27%)(χ~2=9.684, 16.368, P<0.05). The MMSE score of the observation group after treatment was(20.35±2.21)points was significantly higher than that of the control group(18.61±2.18)points(t=3.545, P<0.05). The levels of serum IL-1β, TNF-α and IL-6 in the observation group were(1.79±0.33)ng/L,(1.20±0.13)μg/L,(8.20±1.21)ng/L, were significantly lower than the control group(2.21±0.37)ng/L,(1.75±0.30)μg/L,(11.21±1.19)ng/L(t=5.358,11.284, 11.898, P<0.05). Conclusion For patients with Alzheimer's disease, the treatment with donepezil is effective, improving cognitive function and reducing inflammatory response.
Objective To investigate the clinical efficacy of treatment with donepezil in Alzheimer's disease and its effect on inflammatory factors in patients. Methods A total of 90 patients with Alzheimer's disease admitted to our department from March 2016 to March 2018 in our hospital were divided into two groups according to the random number table, 45 cases in each group. The control group received routine treatment. The observation group was on the basis of conventional treatment added donepezil, compared the clinical efficacy, the simple intelligent mental state examination scale(MMSE) score before and after treatment, serum IL-1β, TNF-α, and IL-6 levels were compared. Results The effective rate and total effective rate of the observation group were significantly higher than those of the control group(62.22% vs 40.00%, 95.56% vs 77.27%)(χ~2=9.684, 16.368, P<0.05). The MMSE score of the observation group after treatment was(20.35±2.21)points was significantly higher than that of the control group(18.61±2.18)points(t=3.545, P<0.05). The levels of serum IL-1β, TNF-α and IL-6 in the observation group were(1.79±0.33)ng/L,(1.20±0.13)μg/L,(8.20±1.21)ng/L, were significantly lower than the control group(2.21±0.37)ng/L,(1.75±0.30)μg/L,(11.21±1.19)ng/L(t=5.358,11.284, 11.898, P<0.05). Conclusion For patients with Alzheimer's disease, the treatment with donepezil is effective, improving cognitive function and reducing inflammatory response.
引文
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[8]周田,熊联慧,李春华,等.奥氮平联合多奈哌齐治疗老年痴呆精神行为障碍的临床疗效分析[J].国际精神病学杂志,2018,45(1):96-99.
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[11]刘召英.奥氮平或喹硫平联合多奈哌齐治疗老年痴呆精神行为症状的疗效和安全性研究[J].中国现代药物应用, 2016,10(17):10-11.
[12]白银,王淑贞,郭洪志,等.盐酸多奈哌齐治疗轻、中度阿尔茨海默病患者临床疗效及血清炎性介质水平变化的动态观察[J].中国老年学杂志,2016,36(8):1871-1873.
[13]赵师德,鲜利群,陈峰.多奈哌齐治疗阿尔茨海默病的临床疗效及其对β淀粉样蛋白、炎性因子的影响研究[J].实用心脑肺血管病杂志,2018,26(1):42-45.
[2]张为,胡才友,吕渊,等.复方丹参片联合多奈哌齐治疗阿尔茨海默病的临床疗效研究[J].中国现代医学杂志,2018(25):37-40.
[3]王琳,杜广清,齐琳.复方脑肽节苷脂联合多奈哌齐治疗阿尔茨海默症的临床研究[J].现代药物与临床,2018,33(8):1907-1910.
[4]郎泽高.盐酸多奈哌齐联合奥氮平治疗阿尔茨海默病伴精神行为症状的效果[J].现代实用医学,2018,30(8):1040-1042.
[5]孙国兵,付斌,谭倩,等.丁苯酞联合多奈哌齐对阿尔茨海默病患者认知功能及脑血管储备功能的影响[J].疑难病杂志,2018,17(8):781-785,865.
[6]包品,孙强.不同剂量多奈哌齐联合美金刚治疗中重度阿尔茨海默病患者有效性和安全性的对比研究[J].实用心脑肺血管病杂志,2018,26(7):77-81.
[7]时婧,左瑞菊,王占强.丁苯酞联合多奈哌齐对阿尔茨海默病患者认知功能及脑血管储备功能的影响[J].临床误诊误治,2018,31(7):98-102.
[8]周田,熊联慧,李春华,等.奥氮平联合多奈哌齐治疗老年痴呆精神行为障碍的临床疗效分析[J].国际精神病学杂志,2018,45(1):96-99.
[9]方玲娟,严依军.盐酸多奈哌齐治疗阿尔茨海默病的临床疗效分析[J].中国神经免疫学和神经病学杂志,2018,25(4):271-273.
[10]李立新,梁永胜.盐酸多奈哌齐治疗老年痴呆临床疗效观察[J].中国实用神经疾病杂志, 2016, 19(14):128-128.
[11]刘召英.奥氮平或喹硫平联合多奈哌齐治疗老年痴呆精神行为症状的疗效和安全性研究[J].中国现代药物应用, 2016,10(17):10-11.
[12]白银,王淑贞,郭洪志,等.盐酸多奈哌齐治疗轻、中度阿尔茨海默病患者临床疗效及血清炎性介质水平变化的动态观察[J].中国老年学杂志,2016,36(8):1871-1873.
[13]赵师德,鲜利群,陈峰.多奈哌齐治疗阿尔茨海默病的临床疗效及其对β淀粉样蛋白、炎性因子的影响研究[J].实用心脑肺血管病杂志,2018,26(1):42-45.