miRNA-29调控乳腺癌发生发展的研究进展
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摘要
miRNA-29(miR-29)家族是微小RNA(microRNAs,miRNAs)家族成员,包括miR-29a、miR-29b和miR-29c,已有报道在多种癌症中异常表达。更多证据表明异常的miR-29表达与肿瘤的发生发展有关,因此,miR-29s是癌症研究中分析良好的一组miRNAs。最新研究表明,miRNA-29作为医学生物领域中重要的肿瘤分子标志物,在乳腺癌的发生、发展进程中发挥着重要作用。本文对miRNA-29调控乳腺癌发生、发展的作用予以概述。
The miRNA-29 family of microRNAs(miRNAs), including miR-29 a, miR-29 b and miR-29 c, were recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29 s a well-analyzed group of miRNAs in cancer research. Recently, it has been found that miRNA-29 family, an important molecular tumor markers in the field of medicalbiotechnology, showing significant differential expression in the development of breast cancer process. To make a review on the recent progress of miRNA-29 roles in tumorigenesis and cancer progression of breast cancer.
The miRNA-29 family of microRNAs(miRNAs), including miR-29 a, miR-29 b and miR-29 c, were recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29 s a well-analyzed group of miRNAs in cancer research. Recently, it has been found that miRNA-29 family, an important molecular tumor markers in the field of medicalbiotechnology, showing significant differential expression in the development of breast cancer process. To make a review on the recent progress of miRNA-29 roles in tumorigenesis and cancer progression of breast cancer.
引文
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[16] Wang C, Bian Z, Wei D, et al. miR-29b regulates migration of human breast cancer cells[J]. Mol Cell Biochem, 2011,352(1-2):197–207.
[17] Chen GQ, Zhao ZW, Zhou HY, et al. Systematic analysis of microRNA involved in resistance of the MCF-7human breast cancer cell to doxorubicin[J]. Med Oncol, 2010,27:406–415.
[18] Muluhngwi P, Krishna A, Vittitow SL, et al. Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells[J]. Cancer Lett, 2017,388:230-238.
[2] Wang Y, Zhang X, Li H, et al. The role of miRNA-29 family in cancer. European Journal of Cell Biology[J]. 2013,92(3):123-128.
[3] Duhachek-Muggy S, Zolkiewska A. ADAM12-L is a direct target of the miR-29 andmiR-200 families in breast cancer[J]. BMC Cancer, 2015,15(1):93.
[4] Duhachek-Muggy S, Li H, Qi Y, et al. Alternative mRNA splicinggenerates two distinct ADAM12 prodomain variants[J]. PLoS One, 2013,8(10):e75730.
[5] Chou J, Lin JH, Brenot A, et al. GATA3 suppresses metastasis and modulates the tumourmicroenvironment by regulating microRNA-29b expression[J]. Nat Cell Biol, 2013,15(2):201-213.
[6] Jacquemier J, Charafe-Jauffret E, Monville F, et al. Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer[J]. Breast Cancer Res,2009,11(2):R23.
[7] Usary J, Llaca V, Karaca G, et al. Mutation of GATA3 in human breast tumors[J]. Oncogene, 2004, 23(46):7669-7678.
[8] Koboldt DC, Fulton RS, McLellan MD, et al. Comprehensive molecular portraits of human breast tumours[J].Nature, 2012,490(7418):61-70.
[9] Hanahan D, Coussens LM. Accessories to the crime:functions of cells recruited to the tumor microenvironment[J]. Cancer Cell, 2012,21(3):309-322.
[10] Lu P, Weaver VM, Werb Z. The extracellular matrix:a dynamic niche in cancer progression[J]. J Cell Biol, 2012,196:395-406.
[11] Padua D, Zhang XH, Wang Q, et al. TGFβprimes breast tumors for lung metastasis seeding through angiopoietin-like 4[J]. Cell, 2008,133(1):66-77.
[12] Zhu M, Susan J, Maria B, et al. Functional Association of Nmi with Stat5 and Stat1 in IL-2-and IFNγ-mediated signaling[J]. Cell, 1999,96(1):121-130.
[13] Rostas JW 3rd, Pruitt HC, Metge BJ, et al. microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer[J]. Mol Cancer, 2014,13:200.
[14] Vares G, Sai S, Wang B, et al. Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells[J].Cancer Lett, 2015,362(2):167-173.
[15] Jiang H, Zhang G, Wu JH, et al. Diverse roles of miR-29in cancer(review)[J]. Oncol Rep, 2014,31(4):1509-1516.
[16] Wang C, Bian Z, Wei D, et al. miR-29b regulates migration of human breast cancer cells[J]. Mol Cell Biochem, 2011,352(1-2):197–207.
[17] Chen GQ, Zhao ZW, Zhou HY, et al. Systematic analysis of microRNA involved in resistance of the MCF-7human breast cancer cell to doxorubicin[J]. Med Oncol, 2010,27:406–415.
[18] Muluhngwi P, Krishna A, Vittitow SL, et al. Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells[J]. Cancer Lett, 2017,388:230-238.