摘要
长链非编码RNA(LncRNA)的生物功能多种多样,在转录的招募、表达、转录后修饰及表观遗传等过程中调控特异性基因的表达,广泛参与机体各种生理和病理过程。脓毒症是一种以器官功能障碍和对感染的异常免疫反应为特征的综合征。脓毒症引起的急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)发病率和死亡率较高。发生于肺部感染或肺外感染后,宿主对感染的异常反应导致肺泡毛细血管屏障破裂,导致肺损伤,表现为低氧血症、炎症和非心源性肺水肿。目前ALI/ARDS的发病机制尚不清楚,缺乏特异性的治疗方法。本文综述lncRNA在调控巨噬细胞、上皮细胞、内皮细胞、成纤维细胞等方面的研究进展,以期为lncRNA在脓毒症肺损伤的研究提供参考。
引文
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