三七及其主要成分对药物代谢酶的影响
|
摘要
探讨三七及其主要成分对药物代谢酶的影响。本文通过查阅近些年国内外有关三七及其主要成分对药物代谢酶的实验研究、作用机制及实验结果等方面的文献,对其进行了综合分析、归纳总结。文献研究结果提示三七及其主要成分可通过抑制或诱导药物代谢酶,改变酶蛋白活性、含量及基因表达,从而影响药物的代谢酶系统,提示三七及其主要成分在药物代谢酶途径中有着重要的作用,对指导临床合理使用三七、研究其作用机制、发现药物作用的新靶点具有重要意义。
To investigate the effect of Panax notoginseng and its main components on drug metabolizing enzymes. In this paper,we reviewed the literature about the experimental study,mechanism of action and experimental results of Panax notoginseng and its major components in recent years at home and abroad,to make comprehensive analyze and summarize. It is found that Panax notoginseng and its main components can affect the drug metabolizing system by inhibiting or inducing drug metabolism enzymes,changing the activity,content and gene expression of enzymes. It suggests that Panax notoginseng and its main components play an important role in the drug metabolic pathway,which may be very important to guide rational use of Panax notoginseng in clinical practice,to research their mechanisms,and find new drug targets.
To investigate the effect of Panax notoginseng and its main components on drug metabolizing enzymes. In this paper,we reviewed the literature about the experimental study,mechanism of action and experimental results of Panax notoginseng and its major components in recent years at home and abroad,to make comprehensive analyze and summarize. It is found that Panax notoginseng and its main components can affect the drug metabolizing system by inhibiting or inducing drug metabolism enzymes,changing the activity,content and gene expression of enzymes. It suggests that Panax notoginseng and its main components play an important role in the drug metabolic pathway,which may be very important to guide rational use of Panax notoginseng in clinical practice,to research their mechanisms,and find new drug targets.
引文
[1]张琴,曾凡琳,张东方,等.基于最大熵模型的三七生态适宜区及生态特征.药学学报,2016,51(10)∶1629~1637.
[2]国家药典委员会.中华人民共和国药典.北京:中国医药科技出版.2015版,一部∶11~12.
[3]夏鹏国,张顺仓,梁宗锁,等.三七化学成分的研究历程和概况.中草药,2014,45(17)∶2564~2570.
[4]王莹,褚扬,李伟,等.三七中皂苷成分及其药理作用的研究进展.中草药,2015,46(9)∶1381~1392.
[5]杨秀芬,廖梅春,杨子明,等.三七对大鼠肺组织内CYP和GST基因表达的影响.中国中药杂志,2009,34(17)∶2236~2240.
[6]Prakash C,Zuniga B,Song C S,et al. Nuclear Receptors in Drug Metabolism,Drug Response and Drug Interactions. Nucl Receptor Res,2015,2∶1~35.
[7]Zanger U M,Schwab M. Cytochrome P450 enzymes in drug metabolism:regulation of gene expression,enzyme activities,and impact of genetic variation. Pharmacol Ther,2013,138∶103~141.
[8]Johnson E F,Connick J P,Reed J R,et al. Correlating structure and function of drug-metabolizing enzymes:progress and ongoing challenges.Drug Metabolism metal Disposition,2014,42(1)∶9~22.
[9]Moorthy B,Chu C,Carlin D J. Polycyclic aromatic hydrocarbons:from metabolism to lung cancer. Toxicol Sci,2015,145(1)∶5~15.
[10]Elshenawy O H,Shoieb S M,Mohamed A,et al. Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney,Liver,Lung and Brain:An Emerging Therapeutic Target. Pharmaceutics,2017,9(1)∶9.
[11]Alex A B,Pal S K,Agarwal N. CYP17 inhibitors in prostate cancer:latest evidence and clinical potential. Ther Adv Med Oncol,2016,8(4)∶267~275.
[12]Daldorff S,Mathiesen R M R,Yri O E,et al. Co targeting of CYP-19(aromatize)and emerging,pivotal signaling pathways in metastatic breast cancer. British Journal of Cancer,2017,116(1)∶10~20.
[13]杨秀芬,廖梅春,杨子明,等.三七对大鼠肝组织内CYP和GST基因表达的影响.中国中药杂志,2009,34(18)∶2390~2393.
[14]胡东华,王宇光,陈志武,等.复方丹参滴丸对大鼠肝细胞色素P450酶的影响.中国药理学与毒理学杂志,2013,27(4)∶678~684.
[15]胡东华,王宇光,陈志武,等.复方丹参方对大鼠心脏细胞色素P450酶的影响.中草药,2014,45(1)∶75~80.
[16]陈艳进,王宇光,马增春,等.三七总皂苷对大鼠肝脏药物代谢酶酶活性、mRNA及蛋白表达的影响.中国中药杂志,2014,39(19)∶3824~3828.
[17]Liu R,Qin M,Hang P,et al. Effects of Panax notoginseng,Saponins on the Activities of CYP1A2,CYP2C9,CYP2D6 and CYP3A4 in Rats In Vivo. Phytother Res,2012,26(8)∶1113~1118.
[18]刘史佳,居文政,陈为烤,等.血栓通注射液对大鼠体内细胞色素P450酶活性的影响.中国药学杂志,2010,45(2)∶115~118.
[19]胡东华,王宇光,陈志武,等.三七总皂苷对H9c2细胞P450酶mRNA表达的影响.中国药理学通报,2013,29(11)∶1563~1567.
[20]Bhatnagar A. Beating ischemia∶a new feat of EETs. Circ Res,2004,95(5)∶443~445.
[21]卜明华,郑咏秋,张颖,等.参麦注射液和注射用血塞通对大鼠肝脏及肠道药物代谢酶CYP450的影响.中国临床药理学杂志,2012,28(1)∶49~52.
[22]杨子明,杨秀芬.三七总皂苷对大鼠肝组织内药物代谢酶CYP3A的抑制作用及其动力学分析.中国中药杂志,2012,37(22)∶3486~3489.
[23]杨子明,杨秀芬.三七总皂苷对小鼠肝脏谷胱甘肽-S-转移酶的抑制作用及其动力学分析.中国中药杂志,2011,36(17)∶2413~2417.
[24]杨晶晶,刘英,王承潇,等.三七皂苷R1的现代研究进展.中国医院药学杂志,2015,35(5)∶463~467.
[25]唐旭东,姜建青,刘宝玉,等.三七总皂苷对心肌缺血再灌注损伤保护作用的分子机制.安徽中医药大学学报,2003,22(1)∶34~38.
[26]Yin S,Cheng Y,Li T,et al. Effects of notoginsenoside R1 on CYP1A2,CYP2C11,CYP2D1,and CYP3A1/2 activities in rats by cocktail probe drugs. Pharm Biol,2015,54(2)∶231~236.
[27]王凌,程能能,毛玉昌.三七总皂苷主要成分对人肝微粒体CYP3A4酶的抑制作用研究.中国药师,2014,17(3)∶353~356.
[28]李成鹏,张梦思,刘俊,等.人参皂苷Rg1延缓脑衰老机制研究.中国中药杂志,2014,39(22)∶4442~4447.
[29]王琼,王逸,韩春勇,等.人参皂苷Rg_1、Rb_1及其代谢产物益智作用的研究进展.中草药,2014,45(13)∶1960~1965.
[30]Wang Y,Ye X,Ma Z,et al. Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in Hep G2 cells. Eur J Pharmacol,2008,601(1-3)∶73~78.
[31]Hao M,B a Q,Yin J,et al. Deglycosylated ginsenosides are more potent inducers of CYP1A1,CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides. Drug Metal Pharmacokinetic,2011,26(2)∶201~205.
[32]王宇光,刘浩生,张娴勰,等.人参中皂苷成分的孕烷X受体激动特性筛选.药学学报,2013,48(1)∶144~148.
[33]李晗,王宇光,马增春,等.人参皂苷Rc、Re、Rf和Rg1对药物代谢酶CYP1A1活性诱导作用研究.中国药理学通报,2016,32(9)∶1217~1223.
[34]杨秋娅,李晓宇,刘皋林.人参皂苷Rb1的药理作用研究进展.中国药学杂志,2013,48(15)∶1233~1237.
[35]Chen Z,Li C,Yang C,et al. Lipid Regulation Effects of Raw and Processed Notoginseng Radix Et Rhizome on Steatotic Hepatocyte L02 Cell. Biomed Res Int,2016,2016(11)∶1~9.
[36]Yang Z,Chen A,Sun H,et al. Ginsenoside Rd elicits Th1 and Th2immune responses to ovalbumin in mice. Vaccine,2007,25(1)∶161~169.
[37]He N,Xie H G,Collins X,et al. Effects of individual ginsenosides,ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes. Clin Exp Pharmacol Physiol,2006,33(9)∶813~815.
[38]Chang T K,Chen J,Benetton S A. In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1,CYP1A2,and CYP1B1. Drug Metab Dispos,2002,30(4)∶378~384.
[39]刘高峰,郭兴蕾.中药对细胞色素P450调控作用的研究进展.中草药,2008,39(1)∶139~143.
[40]陈广通,杨敏,果德安.人参皂苷Re在大鼠体内的代谢研究.中国中药杂志,2009,34(12)∶1540~1543.
[41]X u M,Hao H,Jiang L,et al. Cardiotonic Pill reduces myocardial ischemia-reperfusion injury via increasing EETs concentrations in rats. Drug Metab Dispos,2016,44(7)∶878~887.
[42]马增春,肖勇,赵佳伟,等.人参皂苷Re对H9C2心肌细胞CYP450酶的影响.中国药理学通报,2016,32(4)∶494~498.
[43]Kawase A,Yamada A,Gamow Y,et al. Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism. J Nat Med,2014,68(2)∶395~401.
[44]Li Y,Wang Q,Yao X,et al. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalin, photogenic acid, and ginsenoside Rf through constitutive androstane receptor-and pregnant X receptor-mediated pathways. Eur J Pharmacol,2010,640(1-3)∶46~54.
[2]国家药典委员会.中华人民共和国药典.北京:中国医药科技出版.2015版,一部∶11~12.
[3]夏鹏国,张顺仓,梁宗锁,等.三七化学成分的研究历程和概况.中草药,2014,45(17)∶2564~2570.
[4]王莹,褚扬,李伟,等.三七中皂苷成分及其药理作用的研究进展.中草药,2015,46(9)∶1381~1392.
[5]杨秀芬,廖梅春,杨子明,等.三七对大鼠肺组织内CYP和GST基因表达的影响.中国中药杂志,2009,34(17)∶2236~2240.
[6]Prakash C,Zuniga B,Song C S,et al. Nuclear Receptors in Drug Metabolism,Drug Response and Drug Interactions. Nucl Receptor Res,2015,2∶1~35.
[7]Zanger U M,Schwab M. Cytochrome P450 enzymes in drug metabolism:regulation of gene expression,enzyme activities,and impact of genetic variation. Pharmacol Ther,2013,138∶103~141.
[8]Johnson E F,Connick J P,Reed J R,et al. Correlating structure and function of drug-metabolizing enzymes:progress and ongoing challenges.Drug Metabolism metal Disposition,2014,42(1)∶9~22.
[9]Moorthy B,Chu C,Carlin D J. Polycyclic aromatic hydrocarbons:from metabolism to lung cancer. Toxicol Sci,2015,145(1)∶5~15.
[10]Elshenawy O H,Shoieb S M,Mohamed A,et al. Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney,Liver,Lung and Brain:An Emerging Therapeutic Target. Pharmaceutics,2017,9(1)∶9.
[11]Alex A B,Pal S K,Agarwal N. CYP17 inhibitors in prostate cancer:latest evidence and clinical potential. Ther Adv Med Oncol,2016,8(4)∶267~275.
[12]Daldorff S,Mathiesen R M R,Yri O E,et al. Co targeting of CYP-19(aromatize)and emerging,pivotal signaling pathways in metastatic breast cancer. British Journal of Cancer,2017,116(1)∶10~20.
[13]杨秀芬,廖梅春,杨子明,等.三七对大鼠肝组织内CYP和GST基因表达的影响.中国中药杂志,2009,34(18)∶2390~2393.
[14]胡东华,王宇光,陈志武,等.复方丹参滴丸对大鼠肝细胞色素P450酶的影响.中国药理学与毒理学杂志,2013,27(4)∶678~684.
[15]胡东华,王宇光,陈志武,等.复方丹参方对大鼠心脏细胞色素P450酶的影响.中草药,2014,45(1)∶75~80.
[16]陈艳进,王宇光,马增春,等.三七总皂苷对大鼠肝脏药物代谢酶酶活性、mRNA及蛋白表达的影响.中国中药杂志,2014,39(19)∶3824~3828.
[17]Liu R,Qin M,Hang P,et al. Effects of Panax notoginseng,Saponins on the Activities of CYP1A2,CYP2C9,CYP2D6 and CYP3A4 in Rats In Vivo. Phytother Res,2012,26(8)∶1113~1118.
[18]刘史佳,居文政,陈为烤,等.血栓通注射液对大鼠体内细胞色素P450酶活性的影响.中国药学杂志,2010,45(2)∶115~118.
[19]胡东华,王宇光,陈志武,等.三七总皂苷对H9c2细胞P450酶mRNA表达的影响.中国药理学通报,2013,29(11)∶1563~1567.
[20]Bhatnagar A. Beating ischemia∶a new feat of EETs. Circ Res,2004,95(5)∶443~445.
[21]卜明华,郑咏秋,张颖,等.参麦注射液和注射用血塞通对大鼠肝脏及肠道药物代谢酶CYP450的影响.中国临床药理学杂志,2012,28(1)∶49~52.
[22]杨子明,杨秀芬.三七总皂苷对大鼠肝组织内药物代谢酶CYP3A的抑制作用及其动力学分析.中国中药杂志,2012,37(22)∶3486~3489.
[23]杨子明,杨秀芬.三七总皂苷对小鼠肝脏谷胱甘肽-S-转移酶的抑制作用及其动力学分析.中国中药杂志,2011,36(17)∶2413~2417.
[24]杨晶晶,刘英,王承潇,等.三七皂苷R1的现代研究进展.中国医院药学杂志,2015,35(5)∶463~467.
[25]唐旭东,姜建青,刘宝玉,等.三七总皂苷对心肌缺血再灌注损伤保护作用的分子机制.安徽中医药大学学报,2003,22(1)∶34~38.
[26]Yin S,Cheng Y,Li T,et al. Effects of notoginsenoside R1 on CYP1A2,CYP2C11,CYP2D1,and CYP3A1/2 activities in rats by cocktail probe drugs. Pharm Biol,2015,54(2)∶231~236.
[27]王凌,程能能,毛玉昌.三七总皂苷主要成分对人肝微粒体CYP3A4酶的抑制作用研究.中国药师,2014,17(3)∶353~356.
[28]李成鹏,张梦思,刘俊,等.人参皂苷Rg1延缓脑衰老机制研究.中国中药杂志,2014,39(22)∶4442~4447.
[29]王琼,王逸,韩春勇,等.人参皂苷Rg_1、Rb_1及其代谢产物益智作用的研究进展.中草药,2014,45(13)∶1960~1965.
[30]Wang Y,Ye X,Ma Z,et al. Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in Hep G2 cells. Eur J Pharmacol,2008,601(1-3)∶73~78.
[31]Hao M,B a Q,Yin J,et al. Deglycosylated ginsenosides are more potent inducers of CYP1A1,CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides. Drug Metal Pharmacokinetic,2011,26(2)∶201~205.
[32]王宇光,刘浩生,张娴勰,等.人参中皂苷成分的孕烷X受体激动特性筛选.药学学报,2013,48(1)∶144~148.
[33]李晗,王宇光,马增春,等.人参皂苷Rc、Re、Rf和Rg1对药物代谢酶CYP1A1活性诱导作用研究.中国药理学通报,2016,32(9)∶1217~1223.
[34]杨秋娅,李晓宇,刘皋林.人参皂苷Rb1的药理作用研究进展.中国药学杂志,2013,48(15)∶1233~1237.
[35]Chen Z,Li C,Yang C,et al. Lipid Regulation Effects of Raw and Processed Notoginseng Radix Et Rhizome on Steatotic Hepatocyte L02 Cell. Biomed Res Int,2016,2016(11)∶1~9.
[36]Yang Z,Chen A,Sun H,et al. Ginsenoside Rd elicits Th1 and Th2immune responses to ovalbumin in mice. Vaccine,2007,25(1)∶161~169.
[37]He N,Xie H G,Collins X,et al. Effects of individual ginsenosides,ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes. Clin Exp Pharmacol Physiol,2006,33(9)∶813~815.
[38]Chang T K,Chen J,Benetton S A. In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1,CYP1A2,and CYP1B1. Drug Metab Dispos,2002,30(4)∶378~384.
[39]刘高峰,郭兴蕾.中药对细胞色素P450调控作用的研究进展.中草药,2008,39(1)∶139~143.
[40]陈广通,杨敏,果德安.人参皂苷Re在大鼠体内的代谢研究.中国中药杂志,2009,34(12)∶1540~1543.
[41]X u M,Hao H,Jiang L,et al. Cardiotonic Pill reduces myocardial ischemia-reperfusion injury via increasing EETs concentrations in rats. Drug Metab Dispos,2016,44(7)∶878~887.
[42]马增春,肖勇,赵佳伟,等.人参皂苷Re对H9C2心肌细胞CYP450酶的影响.中国药理学通报,2016,32(4)∶494~498.
[43]Kawase A,Yamada A,Gamow Y,et al. Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism. J Nat Med,2014,68(2)∶395~401.
[44]Li Y,Wang Q,Yao X,et al. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalin, photogenic acid, and ginsenoside Rf through constitutive androstane receptor-and pregnant X receptor-mediated pathways. Eur J Pharmacol,2010,640(1-3)∶46~54.