长链非编码RNA DANCR促滑膜间充质干细胞向软骨细胞分化作用的研究进展
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摘要
长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度大于200 nt,不具有翻译成蛋白质能力的RNA。lncRNA DANCR是一种近年来在肝细胞癌中发现的特异性高表达的长链非编码RNA,具有高度调控细胞分化的作用。最新研究表明,lncRNA DANCR在关节软骨损伤修复中也起着重要的调控作用,并有望成为促进滑膜间充质干细胞(synovium-derived mesenchymal stem cells,SMSCs)向软骨细胞增殖和分化的关键调控位点。文中就近年来DANCR促进SMSCs向软骨细胞增殖和分化过程中的作用及未来可能的研究热点进行综述。
Long non-coding RNA( LncRNA) is an RNA molecule that is longer than 200 nucleotides and is not translated into a protein. LncRNA DANCR has been identified in hepatocellular carcinoma( HCC) and markedly increased stemness features of HCC cells to promote tumorigenesis. Recent studies show that DANCR contributes to the differentiation and proliferation of synovium-derived mesenchymal stem cell( SMSCs) and may be as a key point for this process. This article reviews the role of long non-coding RNA DANCR in enhancing chondrogenic differentiation and proliferation of human SMSCs.
Long non-coding RNA( LncRNA) is an RNA molecule that is longer than 200 nucleotides and is not translated into a protein. LncRNA DANCR has been identified in hepatocellular carcinoma( HCC) and markedly increased stemness features of HCC cells to promote tumorigenesis. Recent studies show that DANCR contributes to the differentiation and proliferation of synovium-derived mesenchymal stem cell( SMSCs) and may be as a key point for this process. This article reviews the role of long non-coding RNA DANCR in enhancing chondrogenic differentiation and proliferation of human SMSCs.
引文
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[30]Laine SK,Alm JJ,Virtanen SP,et al.MicroRNAs miR-96,miR-124,and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells[J].J Cell Biochem,2012,113(8):2687-2695.
[31]Lin EA,Kong L,Bai XH,et al.miR-199a,a bone morphogenic protein 2-responsive MicroRNA,regulates chondrogenesis via direct targeting to Smad1[J].J Biol Chem,2009,284(17):11326-11335.
[32]Zhang Z,Kang Y,Zhang Z,et al.Expression of microRNAs during chondrogenesis of human adipose-derived stem cells[J].Osteoarthritis Cartilage,2012,20(12):1638-1646.
[2]Scotece M,Mobasheri A.Leptin in osteoarthritis:Focus on articular cartilage and chondrocytes[J].Life Sci,2015,140:75-78.
[3]符培亮,张雷,吴海山,等.腺病毒介导BMP-2/7共表达转染兔滑膜MSCs体外向纤维软骨样细胞分化的研究[J].中国修复重建外科杂志,2013,27(3):345-352.
[4]Ham O,Lee CY,Kim R,et al.Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis[J].Int J Mol Sci,2015,16(7):14961-14978.
[5]De Bari C,Dell'Accio F,Tylzanowski P,et al.Multipotent mesenchymal stem cells from adult human synovial membrane[J].Arthritis Rheum,2001,44(8):1928-1942.
[6]Cohen J,Zaleski KL,Nourissat G,et al.Survival of porcine mesenchymal stem cells over the alginate recovered cellular method[J].J Biomed Mater Res A,2011,96(1):93-99.
[7]Xue C,Zhang L,Shuang F,et al.Robust revascularization,despite impaired VEGF production,after meniscus allograft transplantation in rabbits[J].Am J Sports Med,2013,41(11):2668-2675.
[8]Chang CH,Chen CC,Liao CH,et al.Human acellular cartilage matrix powders as a biological scaffold for cartilage tissue engineering with synovium-derived mesenchymal stem cells[J].J Biomed Mater Res A,2014,102(7):2248-2257.
[9]Batista PJ,Chang HY.Long noncoding RNAs:cellular address codes in development and disease[J].Cell,2013,152(6):1298-1307.
[10]Mercer TR,Dinger ME,Mattick JS.Long non-coding RNAs:insights into functions[J].Nat Rev Genet,2009,10(3):155-159.
[11]Zhu L,Xu PC.Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression[J].Biochem Biophys Res Commun,2013,432(4):612-617.
[12]Kretz M,Webster DE,Flockhart RJ,et al.Suppression of progenitor differentiation requires the long noncoding RNA ANCR[J].Genes Dev,2012,26(4):338-343.
[13]Tong X,Gu PC,Xu SZ,et al.Long non-coding RNA-DANCR in human circulating monocytes:a potential biomarker associated with postmenopausal osteoporosis[J].Biosci Biotechnol Biochem,2015,79(5):732-737.
[14]邓齐文,许晔琼,王书奎.长链非编码RNA多态性与肿瘤相关性的研究[J].医学研究生学报,2014,27(3):303-306.
[15]Wang B,Su Y,Yang Q,et al.Overexpression of Long NonCoding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma[J].Mol Cells,2015,38(5):432-440.
[16]胡倩,姚和瑞.长链非编码RNA与肿瘤研究现状[J].中华肿瘤防治杂志,2014,21(21):1746-1750.
[17]胡优,何宋兵,朱新国.MicroRNA与Wnt/β-catenin通路在大肠癌发生发展中的研究进展[J].医学研究生学报,2014,27(2):187-189.
[18]Yuan SX,Wang J,Yang F,et al.Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1[J].Hepatology,2015,63(2):499-511.
[19]Liu Y,Zhang M,Liang L,et al.Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer[J].Int J Clin Exp Pathol,2015,8(9):11480-11484.
[20]Zhang L,Chen S,Bao NR,et al.Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR[J].J Mol Histol,2015,46(6):467-473.
[21]Saegusa M,Hashimura M,Kuwata T.Sox4 functions as a positive regulator of beta-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas[J].Laboratory Investigation,2012,92(4):511-521.
[22]Jang SM,Kim CH,Kim JW,et al.Transcriptional regulatory network of SOX4 during myoblast differentiation[J].Biochem Biophys Res Commun,2015,462(4):365-370.
[23]Chen L,Song Z,Huang S,et al.lncRNA DANCR suppresses odontoblast-like differentiation of human dental pulp cells by inhibiting wnt/beta-catenin pathway[J].Cell Tissue Res,2015,12(8):1007-1012.
[24]Jia Q,Jiang W,Ni L.Down-regulated non-coding RNA(lncRNA-ANCR)promotes osteogenic differentiation of periodontal ligament stem cells[J].Arch Oral Biol,2015,60(2):234-241.
[25]Zhou CC,Yang F,Yuan SX,et al.Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma[J].Hepatology,2016,63(3):850-863.
[26]Ge Y,Yan X,Jin Y,et al.f MiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma[J].PLo S Genet,2015,11(12):e1005726.
[27]Lee S,Kopp F,Chang TC,et al.Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins[J].Cell,2016,164(1-2):69-80.
[28]Gibb EA,Brown CJ,Lam WL.The functional role of long noncoding RNA in human carcinomas[J].Mol Cancer,2011,4(10):35-38.
[29]Huang W,Thomas B,Flynn RA,et al.DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions[J].Nature,2015,528(7583):517-522.
[30]Laine SK,Alm JJ,Virtanen SP,et al.MicroRNAs miR-96,miR-124,and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells[J].J Cell Biochem,2012,113(8):2687-2695.
[31]Lin EA,Kong L,Bai XH,et al.miR-199a,a bone morphogenic protein 2-responsive MicroRNA,regulates chondrogenesis via direct targeting to Smad1[J].J Biol Chem,2009,284(17):11326-11335.
[32]Zhang Z,Kang Y,Zhang Z,et al.Expression of microRNAs during chondrogenesis of human adipose-derived stem cells[J].Osteoarthritis Cartilage,2012,20(12):1638-1646.