乳腺癌根治术后不同放疗技术的应用与剂量分析
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摘要
目的 :分析乳腺癌根治术后不同放疗技术的应用与剂量。方法 :选取2012年2月至2016年4年收治的乳腺癌根治术后患者30例,随机分为对照组与观察组各15例。对照组采用普通放疗计划,观察组采用三维适形放疗,均根据处方剂量50 Gy进行放疗。观察比较两组计划靶区(PTV)剂量参数、分次治疗时间以及近期不良反应。结果 :观察组PTV各剂量参数显著低于对照组(P<0.05),分次治疗时间明显短于对照组(P<0.05),近期不良反应发生率为6.67%(1/15),低于对照组的20.0%(3/15,P<0.05)。结论 :乳腺癌根治术后采用三维适形放疗的效果更为显著,即靶区剂量覆盖均匀性显著较高,且能显著减少危急器官的平均剂量以及高剂量区体积,同时还能减少各种近期不良反应,值得推广应用。
Objective: To analyze the application and dosage of different radiotherapy techniques after radical mastectomy. Methods: Thirty cases of breast cancer after radical mastectomy in 4 years from February 2012 to February 2016 were selected and randomly divided into a control group and an observation group with 15 cases each. The control group was treated with a general radiotherapy plan, and three-dimensional conformal radiotherapy was used in the observation group and the radiotherapy was performed on the basis of prescription agent 50 Gy. The dose parameters, fractional treatment time and shortterm adverse reactions of planned target area(PTV) in two groups were observed and compared. Results: The dose of PTV in the observation group was significantly lower than that in the control group(P<0.05). The treatment time of the observation group was significantly shorter than that of the control group(P<0.05). The incidence of recent adverse reactions was 6.67%(1/15), which was lower than that of the control group 20%(3/15)(P<0.05). Conclusion: The effect of Three-dimensional conformal radiotherapy is more significant after radical mastectomy. That is the dose coverage uniformity in the target area is significantly higher, and it can significantly reduce the average dose of critical organs and the volume of high dose area. At the same time, it can also reduce a variety of adverse reactions in the near future, which is worth popularizing.
Objective: To analyze the application and dosage of different radiotherapy techniques after radical mastectomy. Methods: Thirty cases of breast cancer after radical mastectomy in 4 years from February 2012 to February 2016 were selected and randomly divided into a control group and an observation group with 15 cases each. The control group was treated with a general radiotherapy plan, and three-dimensional conformal radiotherapy was used in the observation group and the radiotherapy was performed on the basis of prescription agent 50 Gy. The dose parameters, fractional treatment time and shortterm adverse reactions of planned target area(PTV) in two groups were observed and compared. Results: The dose of PTV in the observation group was significantly lower than that in the control group(P<0.05). The treatment time of the observation group was significantly shorter than that of the control group(P<0.05). The incidence of recent adverse reactions was 6.67%(1/15), which was lower than that of the control group 20%(3/15)(P<0.05). Conclusion: The effect of Three-dimensional conformal radiotherapy is more significant after radical mastectomy. That is the dose coverage uniformity in the target area is significantly higher, and it can significantly reduce the average dose of critical organs and the volume of high dose area. At the same time, it can also reduce a variety of adverse reactions in the near future, which is worth popularizing.
引文
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[2]年文玲.乳腺癌根治术后三种放疗技术在模体中的剂量监测分析[J].世界最新医学信息文摘,2016,16(13):97,101.
[3]龚敏勇,叶威,熊超.乳腺癌根治术后基于VMAT技术对比静态调强技术对心脏毒性的风险评估[J].中国当代医药,2016,23(29):72-75,78.
[4]王承伟,许刚,薛辉,等.乳腺癌改良根治术后不同放疗技术的剂量学比较及不良反应观察[J].甘肃医药,2016,35(12):881-884.
[5]宋延波.乳腺癌保乳术后选择e Comp放疗技术的影像学几何参数研究[D].重庆:重庆医科大学,2016.
[6]曹瑛.乳腺癌根治术后胸壁调强放疗的浅表剂量研究[D].衡阳:南华大学,2016.
[7]岳亚玲.即刻乳房再造后放疗对美容效果的影响及再造乳房放疗剂量分布的研究[D].石家庄:河北医科大学,2013.
[8]王文岩.应用4DCT技术研究呼吸运动对乳腺癌根治术后调强放疗的影响[D].石家庄:河北医科大学,2013.
[9]韩青.乳腺癌术后患者调强放疗致放射性肺损伤的相关因素分析及Lyman NTCP模型研究[D].南宁:广西医科大学,2015.
[10]陈磊.CTVision技术及体表标记在乳腺癌术后患者精确放疗中摆位误差的研究[D].桂林:桂林医学院,2014.
[11]俞晓立.左侧乳腺癌术后放疗患者心脏主要亚结构的勾画比较及不同放疗技术下的物理剂量和生物剂量比较[D].上海:复旦大学,2009.