男性乳腺癌与女性乳腺癌临床病理学特征对比分析
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摘要
目的:探讨男性乳腺癌的临床病理学特征,并与女性乳腺癌的临床病理学特征进行对比分析。方法:收集2005年1月至2017年12月经病理学确诊的27例男性乳腺癌的临床病理资料,同时选取2017年全部女性乳腺癌655例进行比较分析。结果:与女性乳腺癌的临床病理学特征相比,男性乳腺癌的发病年龄偏大,雌激素受体、孕激素受体表现为高阳性率(P <0.05),且P53低表达(P <0.05);男性乳腺癌的分子亚型主要为Luminal B型,各亚型所占的比例与女性乳腺癌差异有统计学意义(P <0.05)。结论:男性乳腺癌与女性乳腺癌在临床病理学特征的显著性差别,表明两者在生物学行为上可能不全相同,同女性乳腺癌一样,男性乳腺癌的早发现、早诊断对早治疗及改善预后具有重要意义。
Objectives:To investigate the clinical pathological features for male breast cancer, and compare them with female breast cancer. Methods: 27 cases of MBC from January 2005 to December 2017 diagnosed by pathological examination were retrospectively reviewed, and 655 cases of female breast cancer in 2017 were selected for comparative analysis. Results: Compared with female breast cancer, male breast cancer tend to develop at an older age(P < 0.05), with higher estrogen receptor(ER), progesterone receptor(PR)positive expression rate(P < 0.05),meanwhile and lower P53 positive expression rate(P < 0.05); Luminal B is the main molecular subtype of male breast cancer, and the proportion of various subtypes is quite different from that of female breast cancer(P < 0.05).Conclusions:Male breast cancer and female breast cancer on the clinical features are not all the same, showing that they may have different in biological behaviors. The importance of early discovery and early diagnosis for early treatment and prognosis improvement in men is just like breast cancer in women.
Objectives:To investigate the clinical pathological features for male breast cancer, and compare them with female breast cancer. Methods: 27 cases of MBC from January 2005 to December 2017 diagnosed by pathological examination were retrospectively reviewed, and 655 cases of female breast cancer in 2017 were selected for comparative analysis. Results: Compared with female breast cancer, male breast cancer tend to develop at an older age(P < 0.05), with higher estrogen receptor(ER), progesterone receptor(PR)positive expression rate(P < 0.05),meanwhile and lower P53 positive expression rate(P < 0.05); Luminal B is the main molecular subtype of male breast cancer, and the proportion of various subtypes is quite different from that of female breast cancer(P < 0.05).Conclusions:Male breast cancer and female breast cancer on the clinical features are not all the same, showing that they may have different in biological behaviors. The importance of early discovery and early diagnosis for early treatment and prognosis improvement in men is just like breast cancer in women.
引文
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3.Cardoso F,JMS Bartlett,L Slaets,et al.Characterization of male breast cancer:results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program[J].Ann Oncol,2018,29(2):405-417.
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11.师金,梁迪,李道娟,等.全球女性乳腺癌流行情况研究[J].中国肿瘤,2017,26(09):683-690.
12.刘新丽,刘芳芳,郑屹,等.男性乳腺癌临床病理特征及预后分析[J].中国肿瘤临床,2014,41(23):1 521-1 526.
13.刘丽琼,赵志鹏,何明远,等.男性乳腺癌7例临床分析[J].中国实验诊断学,2015,19(04):678-679.
14.吴克瑾,丁龙龙.男性乳腺癌发病危险因素及临床特征[J].中国实用外科杂志,2013,33(03):190-192.
15.邵云,王怀涛,刘甲子,等.男性乳腺癌11例临床病理分析并文献复习[J].临床与病理杂志,2015,35(6):1 020-1 025.
16.Senger,JL,SJ Adams,R Kanthan.Invasive lobular carcinoma of the male breast-a systematic review with an illustrative case study[J].Breast Cancer(Dove Med Press),2017,9:337-345.
17.胡春梅.人表皮生长因子受体-2和Ki-67及雌孕激素受体在男性乳腺癌中的表达及意义[J].中华实用诊断与治疗杂志,2016,30(12):1 213-1 214.
18.Morales,L,A Reigosa,E Caleiras,et al.HER2/neu expression in Venezuelan patients with locally advanced breast cancer[J].Investigación Clínica,2008,49(1):69-78.
19.阳帅,赵强,贺荣芳,等.男性乳腺癌患者12例临床病理特征分析[J].中国现代医药杂志,2014,16(9):9-12.
20.Nilsson,C,I Johansson,C Ahlin,et al.Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact[J].Acta Oncol,2013,52(1):102-109.
2.Merino,MJ,S Gil,CG Macias,et al.The unknown microRNA expression of male breast cancer.Similarities and differences with female ductal carcinoma.Their role as tumor biomarker[J].J Cancer,2018,9(3):450-459.
3.Cardoso F,JMS Bartlett,L Slaets,et al.Characterization of male breast cancer:results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program[J].Ann Oncol,2018,29(2):405-417.
4.Wang Y,P Mettu,A Maltry,et al.Metastatic breast carcinoma to the superior oblique in a male[J].Ophthalmol Ther,2017,6(2):355-359.
5.Harlan,LC,JA Zujewski,MT Goodman,et al.Breast cancer in men in the United States:a population-based study of diagnosis,treatment,and survival[J].Cancer,2010,116(15):3 558-3 568.
6.齐晓伟,姜军.2012年第4版《WHO乳腺肿瘤组织学分类》介绍[J].中华乳腺病杂志,2012,6(5):586-591.
7.李明,杨文涛.2015年St.Gallen早期乳腺癌国际专家共识中病理相关问题的解读[J].中华病理学杂志,2016,45(5):293-296.
8.Eggemann H,A Ignatov,BJ Smith,et al.Adjuvant therapy with tamoxifen compared to aromatase inhibitors for257 male breast cancer patients[J].Breast Cancer Res Treat,2013,137(2):465-470.
9.Streng,M,A Ignatov,M Reinisch,et al.A comparison of tumour size measurements with palpation,ultrasound and mammography in male breast cancer:first results of the prospective register study[J].J Cancer Res Clin Oncol,2018,144(2):381-387.
10.王宁,王斌,王雅杰.乳腺癌患者发病年龄和临床病理学参数的相关性研究[J].临床肿瘤学杂志,2011,16(02):134-138.
11.师金,梁迪,李道娟,等.全球女性乳腺癌流行情况研究[J].中国肿瘤,2017,26(09):683-690.
12.刘新丽,刘芳芳,郑屹,等.男性乳腺癌临床病理特征及预后分析[J].中国肿瘤临床,2014,41(23):1 521-1 526.
13.刘丽琼,赵志鹏,何明远,等.男性乳腺癌7例临床分析[J].中国实验诊断学,2015,19(04):678-679.
14.吴克瑾,丁龙龙.男性乳腺癌发病危险因素及临床特征[J].中国实用外科杂志,2013,33(03):190-192.
15.邵云,王怀涛,刘甲子,等.男性乳腺癌11例临床病理分析并文献复习[J].临床与病理杂志,2015,35(6):1 020-1 025.
16.Senger,JL,SJ Adams,R Kanthan.Invasive lobular carcinoma of the male breast-a systematic review with an illustrative case study[J].Breast Cancer(Dove Med Press),2017,9:337-345.
17.胡春梅.人表皮生长因子受体-2和Ki-67及雌孕激素受体在男性乳腺癌中的表达及意义[J].中华实用诊断与治疗杂志,2016,30(12):1 213-1 214.
18.Morales,L,A Reigosa,E Caleiras,et al.HER2/neu expression in Venezuelan patients with locally advanced breast cancer[J].Investigación Clínica,2008,49(1):69-78.
19.阳帅,赵强,贺荣芳,等.男性乳腺癌患者12例临床病理特征分析[J].中国现代医药杂志,2014,16(9):9-12.
20.Nilsson,C,I Johansson,C Ahlin,et al.Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact[J].Acta Oncol,2013,52(1):102-109.