中药膏方对骨量低下患者骨密度变化的影响
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摘要
目的:研究中药膏方对于骨量低下患者的骨密度影响情况。方法:选取入院或者门诊的经过骨密度检测符合骨量低下的57名患者分为治疗组和对照组两组,治疗组29例,对照组28例,分别进行中药膏方口服结合碳酸钙D3片口服,和单纯碳酸钙D3片口服,后进行骨密度检测,以观察中药膏方对骨密度的影响情况。结果:治疗组前后骨密度存在明显差异:P=0.000<0.05,治疗组和对照组的骨密度改善程度经统计分析存在明显差异:P=0.035<0.05。结论:治疗组与对照组两者应用药物对于患者的骨密度均有一定的改善作用(P<0.05),而从改善程度上看,中药膏方结合碳酸钙D3片应用对于骨密度的改善程度要大于单纯碳酸钙D3(P<0.05)。
Objective:To study the effect of TCM paste on bone mineral density in patients with osteopenia.Methods:The inpatients and outpatients were examined for bone mineral density(BMD) and 57 patients with low bone mass were selected and divided into treatment group and control group.In the treatment group,29 patients were given TCM paste combined with D3 and Calcium Carbonate Tablets and 28 patients in the control group were orally administered with D3 and Calcium Carbonate Tablets.Then two groups were measured bone mineral density and observed the effect of TCM paste on bone mineral density.Results:There was a significant difference in BMD before and after treatment in the treatment group(P=0.000<0.05).There was a significant difference in the improvement of BMD between the treatment group and the control group by statistical analysis:P=0.035<0.05.Conclusion:The treatment group and the control group both had some improvements on the BMD of the patients(P<0.05).From the improvement point of view,the improvement of BMD to a greater extent is better than pure calcium D3(P<0.05).
Objective:To study the effect of TCM paste on bone mineral density in patients with osteopenia.Methods:The inpatients and outpatients were examined for bone mineral density(BMD) and 57 patients with low bone mass were selected and divided into treatment group and control group.In the treatment group,29 patients were given TCM paste combined with D3 and Calcium Carbonate Tablets and 28 patients in the control group were orally administered with D3 and Calcium Carbonate Tablets.Then two groups were measured bone mineral density and observed the effect of TCM paste on bone mineral density.Results:There was a significant difference in BMD before and after treatment in the treatment group(P=0.000<0.05).There was a significant difference in the improvement of BMD between the treatment group and the control group by statistical analysis:P=0.035<0.05.Conclusion:The treatment group and the control group both had some improvements on the BMD of the patients(P<0.05).From the improvement point of view,the improvement of BMD to a greater extent is better than pure calcium D3(P<0.05).
引文
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[2] Odvina CV,Zerwekh JE,Rao DS,et al,Severely suppressed bone turnover:a potential complication of alendronate therapy[J].J Clin Endocrinol Metab,2005,90(3);1294-1301.
[3] Marx RE.Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws:a growing epidemic[J].J Oral Maxillofac Surg,2003,61(9):1115-1117.
[4] 李新建.筋骨内伤与骨病临床诊疗[M].北京:科学技术文献出版社,2006:390-399.
[5] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南:2011年[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17.
[6] Assessment of fracture risk and its application to screening for postm enopausal osteoporosis.Report of a WHO Study Group[R].WHO Technical Report Series,1994:843.
[7] Kanis JA,Melton LJ,Christiansen C,et al.The diagnosis of osteoporosis[J].J Bone Miner Res,1994,9:1137-1141.
[8] 中国老年学学会骨质疏松委员会中医药与骨病学科组.中医药防治原发性骨质疏松症专家共识(2015)[J].中国骨质疏松杂志,2015,21(9):1023-1028.
[9] 阎勇.骨康胶囊联合碳酸钙D3片治疗老年骨质疏松性桡骨远端骨折的临床研究[J].现代药物与临床,2016,11(31),1813-1817.
[10] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):413-444.
[11] 胡咏新,徐书杭,刘超,等.继发性骨质疏松症的诊疗进展[J].实用医学杂志,2015,31(14):2243-2244.
[12] SHI X L,LI C W,WAN Q Z,et al.Drynaria total flavonoids decrease cathepsin K expression in ovariectomizde rats[J].Genet Mol Res,2014,13(2):4311-4319.
[13] 尹文哲,邢成亮,王建业.失重下骨碎补总黄酮经ERK通路促成骨细胞增殖研究[J].中医药学报,2017,45(5):45-47.
[14] MOK S K,CHEN W F,LAI W P,et al.Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells[J].Br J Pharmacol,2010,159(4):939-949.
[15] 郑洪军,吕振华,胡有谷,等.淫羊蕾对体外培养破骨细胞的影响[J].中华实验外科杂志,2000,17(5):460-461.
[16] Chen G,Wang C,Wang J,et al.Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/beta-catenin pathway[J].Exp Ther Med,2016,12:279-287.
[17] 王本祥,现代中药药理学[M].天津:天津科学技术出版社,1997:682.
[18] Ouyang L,Zhang Q,Ruan X,et al.Treatment effect of Bushen Huayu extract on postmenopausal osteoporosis in vivo[J].Exp Ther Med,2014,7:1687-1690.