摘要
<正>Cilia play a wide range of critical roles in regulating cell motility,sensory signaling and metazoan development(Goetz and Anderson,2010;Reiter and Leroux,2017).Both motile cilia and primary cilia consist of a basal body and a microtubule-based axoneme that is encompassed within the ciliary membrane.The formation and maintenance of ciliary structure depends on bidirectional intraflagellar transport(IFT):the kinesin-2 family motor proteins
引文
Arts,H.H.,Bongers,E.M.,Mans,D.A.,van Beersum,S.E.,Oud,M.M.,Bolat,E.,Spruijt,L.,Cornelissen,E.A.,Schuurs-Hoeijmakers,J.H.,de Leeuw,N.,CormierDaire,V.,Brunner,H.G.,Knoers,N.V.,Roepman,R.,2011.C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome.J.Med.Genet.48,390e395.
Blacque,O.E.,Reardon,M.J.,Li,C.,McCarthy,J.,Mahjoub,M.R.,Ansley,S.J.,Badano,J.L.,Mah,A.K.,Beales,P.L.,Davidson,W.S.,Johnsen,R.C.,Audeh,M.,Plasterk,R.H.,Baillie,D.L.,Katsanis,N.,Quarmby,L.M.,Wicks,S.R.,Leroux,M.R.,2004.Loss of C.elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.Genes Dev.18,1630e1642.
Chuang,J.Z.,Zhao,Y.,Sung,C.H.,2007.SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.Cell 130,535e547.
Doroquez,D.B.,Berciu,C.,Anderson,J.R.,Sengupta,P.,Nicastro,D.,2014.A highresolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans.eLife 3,e01948.
Evans,J.E.,Snow,J.J.,Gunnarson,A.L.,Ou,G.,Stahlberg,H.,McDonald,K.L.,Scholey,J.M.,2006.Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans.J.Cell Biol.172,663e669.
Goetz,S.C.,Anderson,K.V.,2010.The primary cilium:a signalling centre during vertebrate development.Nat.Rev.Genet.11,331e344.
Johnson,K.A.,Haas,M.A.,Rosenbaum,J.L.,1994.Localization of a kinesin-related protein to the central pair apparatus of the Chlamydomonas reinhardtii flagellum.J.Cell Sci.107(Pt 6),1551e1556.
Kozminski,K.G.,Beech,P.L.,Rosenbaum,J.L.,1995.The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.J.Cell Biol.131,1517e1527.
Niwa,S.,2016.The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.Sci.Rep.6,31544.
Ou,G.,Blacque,O.E.,Snow,J.J.,Leroux,M.R.,Scholey,J.M.,2005.Functional coordination of intraflagellar transport motors.Nature 436,583e587.
Pazour,G.J.,Agrin,N.,Leszyk,J.,Witman,G.B.,2005.Proteomic analysis of a eukaryotic cilium.J.Cell Biol.170,103e113.
Perkins,L.A.,Hedgecock,E.M.,Thomson,J.N.,Culotti,J.G.,1986.Mutant sensory cilia in the nematode Caenorhabditis elegans.Dev.Biol.117,456e487.
Reese,T.S.,1965.Olfactory cilia in the frog.J.Cell Biol.25,209e230.
Reiter,J.F.,Leroux,M.R.,2017.Genes and molecular pathways underpinning ciliopathies.Nat.Rev.Mol.Cell Biol.18,533e547.
Scholey,J.M.,2013.Kinesin-2:a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions.Annu.Rev.Cell Dev.Biol.29,443e469.
Wang,J.,Silva,M.,Haas,L.A.,Morsci,N.S.,Nguyen,K.C.,Hall,D.H.,Barr,M.M.,2014.C.elegans ciliated sensory neurons release extracellular vesicles that function in animal communication.Curr.Biol.24,519e525.
Wood,C.R.,Huang,K.,Diener,D.R.,Rosenbaum,J.L.,2013.The cilium secretes bioactive ectosomes.Curr.Biol.23,906e911.
Yi,P.,Li,W.J.,Dong,M.Q.,Ou,G.,2017.Dynein-driven retrograde intraflagellar transport is triphasic in C.elegans sensory cilia.Curr.Biol.27,1448e1461 e1447.
Zhu,H.,Chen,L.,Yang,Y.,Zhu,Z.,Zhang,X.,Li,W.,Miao,L.,Zhang,Y.,Ou,G.,2017.The glial actin cytoskeleton regulates neuronal ciliogenesis.Cell Res.27,448e451.