HIV-1 Rev蛋白在病毒复制中的功能
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摘要
<正>人获得性免疫缺陷病毒HIV-1编码的Rev蛋白由116个氨基酸组成,分子量为19 kD,主要定位在细胞核中。Rev具有三个不同的功能区:N端的第35～50个氨基酸之间编码了一个精氨酸富集区域(arginine-rich-motif,ARM)作为Rev的核定位信号(nuclear localization signal,NLS)。Rev的NLS区域主要负责蛋白的核定位功能以及与Rev反应元件(Rev response element,RRE)的茎环RNA序列
引文
[1]Jayaraman B,Mavor D,Gross JD,et al.Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly.Biochemistry,2015,54(42):6545-6554.
[2]Groom HC,Anderson EC,Lever AM.Rev:beyond nuclear export.J Gen Virol,2009,90(Pt 6):1303-1318.
[3]Levin A,Hayouka Z,Friedler A,et al.A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.J Gen Virol,2010,91(Pt 6):1503-1513.
[4]O'Carroll IP,Thappeta Y,Fan L,et al.Contributions of individual domains to function of the HIV-1 Rev response element.J Virol,2017,JVI.00746-17.
[5]Dayton ET,Konings DA,Powell DM,et al.Extensive sequencespecific information throughout the CAR/RRE,the target sequence of the human immunodeficiency virus type 1 Rev protein.J Virol,1992,66(2):1139-1151.
[6]Rausch JW,Le Grice SF.HIV Rev assembly on the Rev response element(RRE):a structural perspective.Viruses,2015,7(6):3053-3075.
[7]Sherpa C,Rausch JW,Le Grice SF,et al.The HIV-1 Rev response element(RRE)adopts alternative conformations that promote different rates of virus replication.Nucleic Acids Res,2015,43(9):4676-4686.
[8]Bischoff FR,Ponstingl H.Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.Nature,1991,354(6348):80-82.
[9]Hoffmann D,Schwarck D,Banning C,et al.Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.PLoS One,2012,7(6):e38305.
[10]Behrens RT,Aligeti M,Pocock GM,et al.Nuclear export signal masking regulates HIV-1 Rev trafficking and viral RNA nuclear export.J Virol,2017,91(3):e02107-e02116.
[11]Bischoff FR,Klebe C,Kretschmer J,et al.RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Proc Natl Acad Sci U S A,1994,91(7):2587-2591.
[12]Budhiraja S,Liu H,Couturier J,et al.Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.J Virol,2015,89(7):3557-3567.
[13]Toro-Ascuy D,Rojas-Araya B,García-de-Gracia F,et al.ARev-CBP80-eIF4AI complex drives Gag synthesis from the HIV-1unspliced m RNA.Nucleic Acids Res,2018,46(21):11539-11552.
[14]Romanov VI,Zolotukhin AS,Aleksandroff NN,et al.Posttranscriptional regulation by Rev protein of human immunodeficiency virus type 1 results in nonrandom nuclear localization of gag m RNA.Virology,1997,228(2):360-370.
[15]Emerman M,Vazeux R,Peden K.The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization.Cell,1989,57(7):1155-1165.
[16]Hadzopoulou-Cladaras M,Felber BK,Cladaras C,et al.The rev(trs/art)protein of human immunodeficiency virus type 1 affects viral m RNA and protein expression via a cis-acting sequence in the env region.J Virol,1989,63(3):1265-1274.
[17]Mancone C,Grimaldi A,Refolo G,et al.Iron overload down-regulates the expression of the HIV-1 Rev cofactor e IF5A in infected T lymphocytes.Proteome Sci,2017,15:18.
[18]Grewe B,Uberla K.The human immunodeficiency virus type 1 Rev protein:ménageàtrois during the early phase of the lentiviral replication cycle.J Gen Virol,2010,91(Pt 8):1893-1897.
[19]Martineau Y,Derry MC,Wang X,et al.Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.Mol Cell Biol,2008,28(21):6658-6667.
[20]Bolinger C,Yilmaz A,Hartman TR,et al.RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1.Nucleic Acids Res,2007,35(8):2629-2642.
[21]Harrison GP,Miele G,Hunter E,et al.Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line.J Virol,1998,72(7):5886-5896.
[22]Brandt S,Blissenbach M,Grewe B,et al.Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation.PLoSPathog,2007,3(4):e54.
[23]Blissenbach M,Grewe B,Hoffmann B,et al.Nuclear RNA export and packaging functions of HIV-1 Rev revisited.J Virol,2010,84(13):6598-6604.
[24]Rosenbluh J,Hayouka Z,Loya S,et al.Interaction between HIV-1Rev and integrase proteins:a basis for the development of anti-HIVpeptides.J Biol Chem,2007,282(21):15743-15753.
[25]Levin A,Hayouka Z,Helfer M,et al.Peptides derived from HIV-1integrase that bind Rev stimulate viral genome integration.PLoS One,2009,4(1):e4155.
[26]Meehan AM,Saenz DT,Morrison JH,et al.LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.PLoSPathog,2009,5(7):e1000522.
[2]Groom HC,Anderson EC,Lever AM.Rev:beyond nuclear export.J Gen Virol,2009,90(Pt 6):1303-1318.
[3]Levin A,Hayouka Z,Friedler A,et al.A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.J Gen Virol,2010,91(Pt 6):1503-1513.
[4]O'Carroll IP,Thappeta Y,Fan L,et al.Contributions of individual domains to function of the HIV-1 Rev response element.J Virol,2017,JVI.00746-17.
[5]Dayton ET,Konings DA,Powell DM,et al.Extensive sequencespecific information throughout the CAR/RRE,the target sequence of the human immunodeficiency virus type 1 Rev protein.J Virol,1992,66(2):1139-1151.
[6]Rausch JW,Le Grice SF.HIV Rev assembly on the Rev response element(RRE):a structural perspective.Viruses,2015,7(6):3053-3075.
[7]Sherpa C,Rausch JW,Le Grice SF,et al.The HIV-1 Rev response element(RRE)adopts alternative conformations that promote different rates of virus replication.Nucleic Acids Res,2015,43(9):4676-4686.
[8]Bischoff FR,Ponstingl H.Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.Nature,1991,354(6348):80-82.
[9]Hoffmann D,Schwarck D,Banning C,et al.Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.PLoS One,2012,7(6):e38305.
[10]Behrens RT,Aligeti M,Pocock GM,et al.Nuclear export signal masking regulates HIV-1 Rev trafficking and viral RNA nuclear export.J Virol,2017,91(3):e02107-e02116.
[11]Bischoff FR,Klebe C,Kretschmer J,et al.RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Proc Natl Acad Sci U S A,1994,91(7):2587-2591.
[12]Budhiraja S,Liu H,Couturier J,et al.Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.J Virol,2015,89(7):3557-3567.
[13]Toro-Ascuy D,Rojas-Araya B,García-de-Gracia F,et al.ARev-CBP80-eIF4AI complex drives Gag synthesis from the HIV-1unspliced m RNA.Nucleic Acids Res,2018,46(21):11539-11552.
[14]Romanov VI,Zolotukhin AS,Aleksandroff NN,et al.Posttranscriptional regulation by Rev protein of human immunodeficiency virus type 1 results in nonrandom nuclear localization of gag m RNA.Virology,1997,228(2):360-370.
[15]Emerman M,Vazeux R,Peden K.The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization.Cell,1989,57(7):1155-1165.
[16]Hadzopoulou-Cladaras M,Felber BK,Cladaras C,et al.The rev(trs/art)protein of human immunodeficiency virus type 1 affects viral m RNA and protein expression via a cis-acting sequence in the env region.J Virol,1989,63(3):1265-1274.
[17]Mancone C,Grimaldi A,Refolo G,et al.Iron overload down-regulates the expression of the HIV-1 Rev cofactor e IF5A in infected T lymphocytes.Proteome Sci,2017,15:18.
[18]Grewe B,Uberla K.The human immunodeficiency virus type 1 Rev protein:ménageàtrois during the early phase of the lentiviral replication cycle.J Gen Virol,2010,91(Pt 8):1893-1897.
[19]Martineau Y,Derry MC,Wang X,et al.Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.Mol Cell Biol,2008,28(21):6658-6667.
[20]Bolinger C,Yilmaz A,Hartman TR,et al.RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1.Nucleic Acids Res,2007,35(8):2629-2642.
[21]Harrison GP,Miele G,Hunter E,et al.Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line.J Virol,1998,72(7):5886-5896.
[22]Brandt S,Blissenbach M,Grewe B,et al.Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation.PLoSPathog,2007,3(4):e54.
[23]Blissenbach M,Grewe B,Hoffmann B,et al.Nuclear RNA export and packaging functions of HIV-1 Rev revisited.J Virol,2010,84(13):6598-6604.
[24]Rosenbluh J,Hayouka Z,Loya S,et al.Interaction between HIV-1Rev and integrase proteins:a basis for the development of anti-HIVpeptides.J Biol Chem,2007,282(21):15743-15753.
[25]Levin A,Hayouka Z,Helfer M,et al.Peptides derived from HIV-1integrase that bind Rev stimulate viral genome integration.PLoS One,2009,4(1):e4155.
[26]Meehan AM,Saenz DT,Morrison JH,et al.LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.PLoSPathog,2009,5(7):e1000522.