卵巢类固醇细胞瘤一例报告
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摘要
卵巢类固醇细胞瘤是较为罕见的卵巢肿瘤,大多为良性肿瘤,但也存在向恶性转化风险,可产生类固醇激素,特别是雄激素。影像学表现缺乏特异性,诊断依据组织病理学及免疫组织化学标记物,手术切除是主要的治疗方法,但近年来也开始尝试使用促性腺激素释放激素类似物治疗此类疾病。回顾性分析吉林大学第二医院收治的1例非特异性卵巢类固醇细胞瘤患者的诊治过程,并结合相关文献对该疾病进行分析。探讨卵巢类固醇细胞瘤的临床诊断和治疗进展,分析其临床特点,以提高对该疾病的诊治水平。
Ovarian steroid cell tumors are rare ovarian tumors. Most of these are benign diseases, but there are also risks of malignant transformation. They can produce steroid hormones, especially androgen. The imaging manifestations of this disease are unspecific. The diagnosis is based on histopathological and immunohistochemical markers. Surgical resection is the main treatment, but people have also begun to try gonadotropin releasing hormone analogues(GnRH α) to treat this disease in recent years. We analyze retrospectively the diagnosis and treatment process of 1 case of non-specific steroid cell tumor at the Second Hospital of Jilin University, and review related literature. We aim to present the progress of the clinical diagnosis and treatment of ovarian steroid cell tumor, as well as analyze its clinical characteristics, in order to improve the diagnosis and treatment level of the disease.
Ovarian steroid cell tumors are rare ovarian tumors. Most of these are benign diseases, but there are also risks of malignant transformation. They can produce steroid hormones, especially androgen. The imaging manifestations of this disease are unspecific. The diagnosis is based on histopathological and immunohistochemical markers. Surgical resection is the main treatment, but people have also begun to try gonadotropin releasing hormone analogues(GnRH α) to treat this disease in recent years. We analyze retrospectively the diagnosis and treatment process of 1 case of non-specific steroid cell tumor at the Second Hospital of Jilin University, and review related literature. We aim to present the progress of the clinical diagnosis and treatment of ovarian steroid cell tumor, as well as analyze its clinical characteristics, in order to improve the diagnosis and treatment level of the disease.
引文
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[9]Bettegowda A,Rangaiah N,Prasad N,et al.Virilizing Ovarian Steroid Cell Tumor:A Rare Case[J].J Clin Diagn Res,2015,9(9):QD05-QD06.
[10]Boyraz G,Selcuk I,Yusifli Z,et al:Steroid cell tumor of the ovary in an adolescent:a rare case report[J].Case Rep Med,2013,2013:527698.
[11]Tai YJ,Chang WC,Kuo KT,et al.Ovarian steroid cell tumor,not otherwise specified,with virilization symptoms[J].Taiwan J Obstet Gynecol,2014,53(2):260-262.
[12]Zang L,Ye M,Yang G,et al.Accessory ovarian steroid cell tumor producing testosterone and cortisol:A case report[J].Medicine(Baltimore),2017,96(37):e7998.
[13]Qian L,Shen Z,Zhang X,et al.Ovarian steroid cell tumor,not otherwise specified:A case report and literature review[J].Mol Clin Oncol,2016,5(6):839-841.
[14]Kim YT,Kim SW,Yoon BS,et al.An ovarian steroid cell tumor causing virilization and massive ascites[J].Yonsei Med J,2007,48(1):142-146.
[15]Pascale MM,Pugeat M,Roberts M,et al.Androgen suppressive effect of GnRH agonist in ovarian hyperthecosis and virilizing tumours[J].Clin Endocrinol(Oxf),1994,41(5):571-576.
[16]Das A,Panda S,Singh AS.Steroid cell tumor:A rare virilizing ovarian tumor[J].J Cancer Res Ther,2015,11(3):660.
[17]Jiang W,Tao X,Fang F,et al.Benign and malignant ovarian steroid cell tumors,not otherwise specified:case studies,comparison,and review of the literature[J].J Ovarian Res,2013,6:53.
[2]Taylor HB,Norris HJ.Lipid cell tumors of the ovary[J].Cancer,1967,20(11):1953-1962.
[3]Oz M,OzgüE,Türker M,et al.Steroid cell tumor of the ovary in a pregnant woman whose androgenic symptoms were masked by pregnancy[J].Arch Gynecol Obstet,2014,290(1):131-134.
[4]Wan J,Chen X,Li X.Ovarian steroid cell tumor,not otherwise specified:A rare case of postmenopausal vaginal bleeding[J].Oncol Lett,2014,8(3):1187-1189.
[5]Sood N,Desai K,Chindris AM,et al.Symptomatic Ovarian Steroid Cell Tumor not Otherwise Specified in a Post-Menopausal Woman[J].Rare Tumors,2016,8(2):6200.
[6]Lee J,John VS,Liang SX,et al.Metastatic Malignant Ovarian Steroid Cell Tumor:A Case Report and Review of the Literature[J].Case Rep Obstet Gynecol,2016,2016:6184573.
[7]Tsai HJ,Chen SC,Wei HY,et al.Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor,not otherwise specified[J].Gynecol Endocrinol,2007,23(2):69-71.
[8]Luk WT,Lee N,Chang TC,et al.Lipid cell tumor of the ovary associated with endometrial adenocarcinoma--a case report[J].Changgeng Yi Xue Za Zhi,1989,12(4):244-248.
[9]Bettegowda A,Rangaiah N,Prasad N,et al.Virilizing Ovarian Steroid Cell Tumor:A Rare Case[J].J Clin Diagn Res,2015,9(9):QD05-QD06.
[10]Boyraz G,Selcuk I,Yusifli Z,et al:Steroid cell tumor of the ovary in an adolescent:a rare case report[J].Case Rep Med,2013,2013:527698.
[11]Tai YJ,Chang WC,Kuo KT,et al.Ovarian steroid cell tumor,not otherwise specified,with virilization symptoms[J].Taiwan J Obstet Gynecol,2014,53(2):260-262.
[12]Zang L,Ye M,Yang G,et al.Accessory ovarian steroid cell tumor producing testosterone and cortisol:A case report[J].Medicine(Baltimore),2017,96(37):e7998.
[13]Qian L,Shen Z,Zhang X,et al.Ovarian steroid cell tumor,not otherwise specified:A case report and literature review[J].Mol Clin Oncol,2016,5(6):839-841.
[14]Kim YT,Kim SW,Yoon BS,et al.An ovarian steroid cell tumor causing virilization and massive ascites[J].Yonsei Med J,2007,48(1):142-146.
[15]Pascale MM,Pugeat M,Roberts M,et al.Androgen suppressive effect of GnRH agonist in ovarian hyperthecosis and virilizing tumours[J].Clin Endocrinol(Oxf),1994,41(5):571-576.
[16]Das A,Panda S,Singh AS.Steroid cell tumor:A rare virilizing ovarian tumor[J].J Cancer Res Ther,2015,11(3):660.
[17]Jiang W,Tao X,Fang F,et al.Benign and malignant ovarian steroid cell tumors,not otherwise specified:case studies,comparison,and review of the literature[J].J Ovarian Res,2013,6:53.