摘要
研究fat-1基因功能的作用机理对充分合理利用多不饱和脂肪酸(PUFAs)资源具有重要意义,建立转fat-1基因动物模型是了解fat-1基因功能、作用机理的重要方法。文章详细阐述了fat-1基因通过n-3 PUFAs而发挥的生理功能、转fat-1基因动物神经系统疾病模型、转fat-1基因动物肿瘤疾病模型、转fat-1基因炎症动物疾病模型及作用机理研究进展,并对转fat-1基因动物抗肥胖作用机理、转fat-1基因动物在优质家畜育种改良中的作用、利用转fat-1基因动物模型研究骨骼肌发育机理和糖尿病的治疗方法等方面的进展进行了总结,以期为合理利用PUFAs资源和优质家畜改良育种提供理论依据。
The study of the functional mechanism of fat-1 gene is very important to the full rational utilization of unsaturated fatty acid resources,the establishment of fat-1 transgenic animal model is an important way to understand the mechanism of n-3 PUFAs function. The article describes in detail the physiological function of the fat-1 gene, the animal nervous system disease model of the transfat-1 gene, the animal tumor disease model of the transfat-1 gene, the animal disease model of the transfat-1 gene inflammation, and the progress in research on the mechanism of action.The mechanism of anti-obesity action of transfat-1 gene animals, the role of transfat-1 gene animals in breeding improvement of high-quality livestock, the mechanism of skeletal muscle development using transfat-1 gene animal model and the treatment of diabetes were summarized to provide a theoretical basis for the rational use of PUFAs resources and high-quality livestock breeding improvement.
引文
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