人类白细胞相关抗原G在移植免疫中的作用及其研究进展
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摘要
人类白细胞相关抗原G(human leukocyte antigen-G,HLA-G)是一类非典型的人白细胞抗原I类分子(human lym-phocyte antigen I,HLA-I),最早发现其表达在母胎界面的绒毛膜滋养层层细胞表面,蛋白产物有HLA-G膜结合型和可溶性分子型。国内外多项研究表明HLA-G分子在免疫耐受状态的形成及维持中具有重要作用。现就其基因及蛋白产物表达特点、诱导免疫耐受的机制及临床移植应用研究做简要综述。
引文
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[25]Colonna M,Samaridis J,Cella M,et al.Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules[J].Immunol,1998,160(7):3096-3100.
[26]Ponte M,Cantoni C,Biassoni R,et al.Inhibitory receptors sensing HLA-G1molecules in pregnancy:deciduas-associated natual killer cells express LIR-1and CD94/NKG2A and acquire p94,an HLA-G1-specific receptor[J].Proc Natl Acad Sci USA,1999,965(11):5674-5679.
[27]Khalil-daher I,Rouas-Freiss N,Carosella ED,et al.HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes[J].Interna-tional Immunol,1999,11(8):1351-1356.
[28]LeMaoult J,Zafaranloo K,Le Danff C,et al.HLA-G up-regulates ILT2,ILT3,ILT4and KIR2DL4in antigen presenting cells,NK cells,and T cells[J].FASEB J,2005,19(6):662-664.
[29]Contini P,Ghio M,Poggi A,et al.Soluble HLA-A,-B,-C and-G molecules induce apoptosis in T and NK CD8+cells and inhibit cyto-toxic T cell activity through CD8ligation[J].Immunol,2003,33(1):125-134.
[30]Nermine L,Alain C,Catherine A,et al.Implication of HLA-G mole-cule in heart-graft acceptance[J].THE LANCET,2000,355(9221):2138.
[31]Qiu J,Terasaki PI,Miller J,et al.Soluble HLA-G expression and re-nal graft acceptance[J].Am J Transplant,2006,6(9):2152-2156.
[32]Luque J,Torres MI,Aumente MD,et al.Soluble HLA-G in heart transplantation:their relationship to rejection episodes and immuno-suppressive therapy[J].Hum Immunot,2006,67(4-5):257-263.
[2]Nermine L,Catherine A,Romain G,et al.Human leukocyte Antigen-G Expression After Heart Transplantation Is Associated With a Re-duced Incidence of Rejection[J].Circulation,2002,105(23):1949-1954.
[3]Hunt JS,Petroff MG,Mclntire RH,et al.HLA-G and immune toler-ance in pregnancy[J].The FASEB Journal,2005,19:681-693.
[4]Bodmer JG,Marsh SGE,Albert ED,et al.Nomenclature for factors of the HLA system[J].Human Immunol,1997,24(2):105-151.
[5]van der Ven K,Skrablin S,Engels G,et al.HLA-G polymorphisms and allele frequencies in Caucasians[J].Hum Immunol,1998,59(5):302-312.
[6]Yamashita T,Fujii T,Tokunaga K,et al.Analysis of human leukocyte antigen-G polymorphism including intron4in Japanese couples with habitual abortion[J].Am J Reprod Immunol,1999,41(2):159-63.
[7]Amashita T,Fujii T,Tokunaga K.Analysis of human leukocyte anti-gen-G polymorphism including intron4in Janpanese couples with habitual abortion[J].Am J Reprod Immunol,1999,41(2):159-63.
[8]Favier B,LeMaoult J,Carosella ED.Functions of HLA-G in the im-mune system[J].Tissue Antigens,2007,763(6):150-152.
[9]Wiendl H,Mitsdoerffer M,Hofmeister V,et al.A functional role of HLA-G expression in human gliomas:an alternative strategy of im-mune escape[J].The Journal of Immunology,2002,168(9):4772-4780.
[10]Lefebvre S,Adrian F,Moreau P,et al.Modulation of HLA-G expres-sion in human thymic and amniotic epithelial cells[J].Human Im-munology,2000,61(11):1095-1011.
[11]Favier B,LeMaoult J,Carosella ED.Functions of HLA-G in the im-mune system[J].Tissue Antigens,2007,69(1):150-152.
[12]Rouas-Freiss N,Marchal RE,Kirszenbaum M,et al.The alpha1do-main of HLA-G1and HLA-G2inhibits cytocicity induced by natural killer cells:is HLA-G the public ligand for natural killer cells inhibi-tory receptors[J].Proc Natl Acad Sci USA,1997,94(10):5249-5254.
[13]Le Gal FA,Riteau B,Sedlik C,et al.HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes[J].International Immunol,1999,11(8):1351-1356.
[14]Marcal-Bras-Goncalves R,Rouas-Freiss N,Connan F,et al.A soluble HLA-G protein that inhibits natural killer cell-mediated cytotoxicity[J].Transplant Proc,2001,33(3):2355-2359.
[15]Creput C,Le Friec G,Bahri R,et al.Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following com-bined liver-kidney transplantation:possible implications for monito-ring patients[J].Hum Immunol,2003,64(11):1033-1038.
[16]Horuzsko A,Lenfant F,Munn DH,Melleor AL.Maturation of anti-gen-presenting cells is compromised in HLA-G transgenic mice[J].International Immunol,2001,13(3):385-394.
[17]Ristich V,Liang S,Zhang W,et al.Tolerization of dendritic cells by HLA-G[J].Eur J Immunol,2005,35(4):1133-1142.
[18]Liang S,Baibakov B,Horuzsko A.HLA-Ginhibits the function of mu-rine dentritic cells via the PIR-B immune inhibitory receptor[J].Eur J Immunol,2002,32(9):2418-2426.
[19]Kanai T,Fujii T,Unno N,et al.Human leukocyte antigen HLA-G ex-pressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood[J].American Journal of Reproductive Immunology,2001,45(2):94-99.
[20]Easterfield AJ,Austem BM,Westwood OM.Inhibition of antigen transport by expression of infected cell peptide47(ICP47)prevents cell surface expression of HLA in choriocarcinoma cell bines[J].Re-prod immunol,2001,50(1):19-40.
[21]Rizzo R,Hviid TV,Stignani M,et al.The HLA-G genotype is associ-ated with IL10levels in activated PBMCs[J].Immunogenetics,2005,57(3-4):172-181.
[22]Colonna M,Navarro F,Bellon T,et al.A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells[J].J Exp Med,1997,186(11):1809-1818.
[23]Cosman D,Fanger N,Borges L,et al.A novel immunoglobulin super-family receptor for cellular and viral MHC class I molecules[J].Im-munity,1997,7(2):273-282.
[24]Saverino D,Fabbi M,Ghiotto F,et al.The CD85/LIR-1/ILT2inhibi-tory receptor is expressed by all human T lymphocytes and down-reg-ulates their functions[J].J immunol,2001,165(7):3742-3755.
[25]Colonna M,Samaridis J,Cella M,et al.Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules[J].Immunol,1998,160(7):3096-3100.
[26]Ponte M,Cantoni C,Biassoni R,et al.Inhibitory receptors sensing HLA-G1molecules in pregnancy:deciduas-associated natual killer cells express LIR-1and CD94/NKG2A and acquire p94,an HLA-G1-specific receptor[J].Proc Natl Acad Sci USA,1999,965(11):5674-5679.
[27]Khalil-daher I,Rouas-Freiss N,Carosella ED,et al.HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes[J].Interna-tional Immunol,1999,11(8):1351-1356.
[28]LeMaoult J,Zafaranloo K,Le Danff C,et al.HLA-G up-regulates ILT2,ILT3,ILT4and KIR2DL4in antigen presenting cells,NK cells,and T cells[J].FASEB J,2005,19(6):662-664.
[29]Contini P,Ghio M,Poggi A,et al.Soluble HLA-A,-B,-C and-G molecules induce apoptosis in T and NK CD8+cells and inhibit cyto-toxic T cell activity through CD8ligation[J].Immunol,2003,33(1):125-134.
[30]Nermine L,Alain C,Catherine A,et al.Implication of HLA-G mole-cule in heart-graft acceptance[J].THE LANCET,2000,355(9221):2138.
[31]Qiu J,Terasaki PI,Miller J,et al.Soluble HLA-G expression and re-nal graft acceptance[J].Am J Transplant,2006,6(9):2152-2156.
[32]Luque J,Torres MI,Aumente MD,et al.Soluble HLA-G in heart transplantation:their relationship to rejection episodes and immuno-suppressive therapy[J].Hum Immunot,2006,67(4-5):257-263.