面向生物流体泵送的AGET微泵性能优化评价
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摘要
生物流体的进样和高效泵送是在微流控芯片上进行检测的基础。机械式微泵成本较高,具有复杂的结构并且很难微型化,而交流电热微泵不含运动部件,尺寸小,结构简单易于集成在微流控芯片上。现有对交流电热微泵性能的评价参数只有泵送速率,针对交流电热流场的特点,按照信噪比、净流速和泵送效率等无量纲评价参数设计一种低成本的面向生物流体的泵送装置,以交流电驱动微泵通道内的流体,实现对生物流体的可控泵送。利用多物理场耦合模型,优化交流电热微泵的结构,通过数值计算得出微泵的泵送速率表,对交流电热微泵的应用有重要的参考意义。
The injection and efficient pumping of biofluids are the basis to test microfluidic chips. However, the mechanical micropump is expensive, complex and difficult to be miniaturized. There are not any moving parts in the AC electrothermal(ACET) micropump, and it is tiny and simple. Therefore, the ACET micropump is easy to be integrated on the microfluidic chip. The current evaluation parameter for the performance of the ACET micropump is only pumping velocity. For this reason, aiming to the characteristics of AC electrothermal flow, according to the signal-to-noise ratio, net flow rate and pumping efficiency, evaluation parameters of the ACET micropump, a low cost biofluids pumping device were designed. Driven by the alternating current, biofluids are controllable in micropump's channel. Through the multi-physical fields coupling model, the ACET micropump was optimized. The pumping velocity table was obtained by numerical calculation, which is referable to the application of ACET micropump.
The injection and efficient pumping of biofluids are the basis to test microfluidic chips. However, the mechanical micropump is expensive, complex and difficult to be miniaturized. There are not any moving parts in the AC electrothermal(ACET) micropump, and it is tiny and simple. Therefore, the ACET micropump is easy to be integrated on the microfluidic chip. The current evaluation parameter for the performance of the ACET micropump is only pumping velocity. For this reason, aiming to the characteristics of AC electrothermal flow, according to the signal-to-noise ratio, net flow rate and pumping efficiency, evaluation parameters of the ACET micropump, a low cost biofluids pumping device were designed. Driven by the alternating current, biofluids are controllable in micropump's channel. Through the multi-physical fields coupling model, the ACET micropump was optimized. The pumping velocity table was obtained by numerical calculation, which is referable to the application of ACET micropump.
引文
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[15] F J Hong,F Bai,P Cheng.Numerical simulation of AC electrothermal micropump using a fully coupled model[J].Microfluidics and Nanofluidics,2012,13(3):411-420.
[2] 林炳承.微流控芯片的研究及产业化[J].分析化学,2016,44(4):491-499.
[3] W Liu,et al.Interfacing microsampling droplets and mass spectrometry by paper spray ionization for online chemical monitoring of cell culture[J].Analytical Chemistry,2014,86(14):7128-7134.
[4] S C Th,C D Reyes,G P López.Microfluidic cell sorting:a review of the advances in the separation of cells from debulking to rare cell isolation.[J].Lab on A Chip,2015,15(5):1230-1249.
[5] D Hümmer,et al.Single cells in confined volumes:microchambers and microdroplets[J].Lab on A Chip,2015,16(3):447-458.
[6] E K Sackmann,A L Fulton,D J Beebe.The present and future role of microfluidics in biomedical research[J].Nature,2014,507(7491):181-189.
[7] T Nisisako,T Ando,T Hatsuzawa.Capillary-Assisted Fabrication of Biconcave Polymeric Microlenses from Microfluidic Ternary Emulsion Droplets[J].Small,2014,10(24):5116.
[8] Q Yuan,N Islam,J Wu.AC electrokinetics based capture of yeast cells from ultra-fast through-flow for sensitive detection[J].Iet Micro & Nano Letters,2017,12(11):901-906.
[9] M F Al-Rjoub,et al.Improved Flow Rate in Electro-Osmotic Micropumps for Combinations of Substrates and Different Liquids With and Without Nanoparticles[J].Journal of Electronic Packaging,2015,137(2):1-2.
[10] M Lian,J Wu.Ultrafast micropumping by biased alternating current electrokinetics[J].Applied Physics Letters,2009,94(6):1-3.
[11] R Zhang,G A Jullien,C Dalton.Study on an alternating current electrothermal micropump for microneedle-based fluid delivery systems[J].Journal of Applied Physics,2013,114(2):1-8.
[12] R H Vafaie,et al.Bi-directional AC electrothermal micropump for on-chip biological applications[J].Electrophoresis,2016,37(6):719-726.
[13] A Salari,M Navi,C Dalton.A novel alternating current multiple array electrothermal micropump for lab-on-a-chip applications[J].Biomicrofluidics,2015,9(1):1-14.
[14] Q Yuan,J Wu.Thermally biased AC electrokinetic pumping effect for Lab-on-a-chip based delivery of biofluids[J].Biomedical Microdevices,2013,15(1):125-133.
[15] F J Hong,F Bai,P Cheng.Numerical simulation of AC electrothermal micropump using a fully coupled model[J].Microfluidics and Nanofluidics,2012,13(3):411-420.