mFolFox6方案时辰化疗治疗晚期结直肠癌临床观察
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摘要
目的观察m FolFox6方案时辰化疗治疗晚期结直肠癌的临床近期疗效、不良反应和生活质量改善情况。方法 78例晚期结直肠癌患者随机分为时辰组(40例)和对照组(常规化疗组38例),两组均采用m FolFox6方案全身化疗,每21天为一个周期,共4～6个周期。结果时辰组近期疗效明显高于对照组(P<0.05),不良反应低于对照组(P<0.05),化疗后生活质量改善的有效率时辰组高于对照组(P<0.05)。结论 mFolFox6方案时辰化疗治疗晚期结直肠癌近期疗效较好,可以改善生活质量,不良反应较轻,可在临床上推广应用。
Objective To observe the short-term clinical efficacy, adverse reactions and quality of life improvement of mFolFox6 regimen chronochemotherapy for advanced colorectal cancer. Methods 78 patients with advanced colorectal cancer were randomly divided into two groups: the chronochemotherapy group (40 cases) and the control group (38 cases) with conventional chemotherapy. Both groups were treated with mFolFox6 regimen for systemic chemotherapy, every 21 days is a cycle, a total of 4~6 cycles. Results The short-term curative effect of the chronochemotherapy group wassignificantly higher than that of the control group (P<0.05), and the adverse reactionwas lower than that of the control group (P<0.05). The effective rate of improvingthe quality of life of the chronochemotherapy group was higher than that of thecontrol group (P<0.05). Conclusion mFolFox 6 regimen chronochemotherapy for advanced colorectal cancer has a good short-term efficacy, can improve the quality of life, less adverse reactions, and can be promoted in clinical application.
Objective To observe the short-term clinical efficacy, adverse reactions and quality of life improvement of mFolFox6 regimen chronochemotherapy for advanced colorectal cancer. Methods 78 patients with advanced colorectal cancer were randomly divided into two groups: the chronochemotherapy group (40 cases) and the control group (38 cases) with conventional chemotherapy. Both groups were treated with mFolFox6 regimen for systemic chemotherapy, every 21 days is a cycle, a total of 4~6 cycles. Results The short-term curative effect of the chronochemotherapy group wassignificantly higher than that of the control group (P<0.05), and the adverse reactionwas lower than that of the control group (P<0.05). The effective rate of improvingthe quality of life of the chronochemotherapy group was higher than that of thecontrol group (P<0.05). Conclusion mFolFox 6 regimen chronochemotherapy for advanced colorectal cancer has a good short-term efficacy, can improve the quality of life, less adverse reactions, and can be promoted in clinical application.
引文
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[2]Krogh K.Management of coloectal problems in spianl Cord injured patients[J].Medical Services journal,2006,22(7):698-710.
[3]中华医学会肿瘤分会.中国结直肠癌诊疗规范(2017年版)[J],中华外科杂志.2018,56(4):241-258.
[4]石远凯,孙燕.临床肿瘤内科手册[M].6版.北京:人民卫生出版社,2015:428-429.
[5]张文.肿瘤[M].北京:人民卫生出版社,2015:209-213.
[6]赵秋玲.抗肿瘤药物时辰药理学进展[J].海峡药学,2012,24(10):147-148.
[7]陈昕,杨建,龚光,等.奥沙利铂/氟尿嘧啶改良时辰化疗治疗晚期结直肠癌[J].现代肿瘤医学,2009,17(3):517-518.
[8]陆建伟,周兆飞,尹必俭,等.奥沙利铂联合5-氟尿嘧啶和醛氢叶酸钙时辰治疗晚期胃癌的初步临床研究[J].中华肿瘤杂志,2005,27(11):695-697.
[9]郭灵,林焕新,冼励坚.恶性肿瘤时辰化疗的基础理及实践[J].中国肿瘤临床,2004,31(1):56-59.
[10]熊娟,李光明.生物钟基因与肿瘤时辰治疗的研究进展[J].现代肿瘤医学,2013,21(11):2622-2625.
[11]郑超.时辰化疗用于肿瘤化疗的临床效果分析[J].现代诊断与治疗,2012,23(11):2003.
[12]杜思倩,周颖,崔一民.妇科恶性肿癌的时展化疗进展[J].中国药业,2012,21(23):1-3.
[13]陈昕,梁超,雷开键,等.时辰化疗作用机制的生物学研究进展[J].现代预防医学,2008,35(2):201-202.
[14]唐玉亮.时辰药理学与合理用药[J].中国药业,2011,20(15):90-92.
[15]Samuel B,?ajavec Bernard Branka,Francis L,et al.Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules[J].
[16]钟丽,吴敬波.肿瘤时晨治疗的临床研究进展[J].实用癌症杂志,2008,23(3):307-309.