TP73-AS1在肿瘤中的表达及调控作用
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摘要
<正>随着高通量测序技术的发展,成千上万种长链非编码RNA(long non-coding RNA,lncRNA)进入人们的视野。lncRNA是一类长度超过200个核苷酸并缺少开放阅读框的不具备蛋白质编码功能的RNA~([1-2])。研究发现lncRNA参与诸多生物学进程的关键步骤,包括染色质重塑、基因转录、转录后调节和蛋白质翻译等~([3-5])。LncRNA机制的不断被阐明,也为肿瘤的研究提供了新的可能。LncRNA在多种肿瘤的增殖、迁移侵袭和抗凋亡
The discovery of abundant new long non-coding RNAs(lncRNAs) and extensive investigation of their roles in various diseases have been reported, especially in cancers. The lncRNA P73 antisense RNA 1 T(TP73-AS1) is involved in dysregulation of cell signaling and closely correlated with cancer development, progression, and response to therapy. This review is a brief update of the current knowledge related to the role of TP73-AS1 in cancer-associated molecular pathways and pathophysiology, and possible determinants for TP73-AS1 to function as a biomarker, aiming to stimulate the basic investigation of TP73-AS1 as well as its translation to clinical applications.
The discovery of abundant new long non-coding RNAs(lncRNAs) and extensive investigation of their roles in various diseases have been reported, especially in cancers. The lncRNA P73 antisense RNA 1 T(TP73-AS1) is involved in dysregulation of cell signaling and closely correlated with cancer development, progression, and response to therapy. This review is a brief update of the current knowledge related to the role of TP73-AS1 in cancer-associated molecular pathways and pathophysiology, and possible determinants for TP73-AS1 to function as a biomarker, aiming to stimulate the basic investigation of TP73-AS1 as well as its translation to clinical applications.
引文
[1] Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways[J]. Cancer Cell, 2016, 29(4):452-463.
[2] 覃伟峰, 仉红刚. lncRNA在心血管疾病中作用的研究进展[J]. 中国病理生理杂志, 2016, 32(8):1471-1477.
[3] Zhou M, Wang X, Shi H, et al. Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer[J]. Oncotarget, 2016, 7(11):12598-12611.
[4] 张明娇, 吴勇, 李珉珉. 长链非编码RNAs的生物功能及其与器官发育和恶性肿瘤的关系[J]. 中国病理生理杂志, 2015, 31(11):2107-2112.
[5] 李正龙, 徐艺, 冷开明, 等. 长链非编码RNA SOX2OT在肿瘤中的调控作用及对预后的影响[J]. 现代肿瘤医学, 2018, 26(14):2290-2293.
[6] Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism[J]. Bioessays, 2016, 38(10):991-996.
[7] Xiao S, Wang R, Wu X, et al. The long noncoding RNA TP73-AS1 interacted with miR-124 to modulate glioma growth by targeting inhibitor of apoptosis-stimulating protein of p53[J]. DNA Cell Biol, 2018, 37(2):117-125.
[8] Dominguez G, Garcia JM, Pena C, et al. DeltaTAp73 upregulation correlates with poor prognosis in human tumors:putative in vivo network involving p73 isoforms, p53, and E2F-1[J]. J Clin Oncol, 2006, 24(5):805-815.
[9] Zitterbart K, Zavrelova I, Kadlecova J, et al. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival[J]. Acta Neuropathol, 2007, 114(6):641-650.
[10] Wang JB, Liu FH, Chen JH, et al. Identifying survival-associated modules from the dysregulated triplet network in glioblastoma multiforme[J]. J Cancer Res Clin Oncol, 2017, 143(4):661-671.
[11] Zhang R, Jin H, Lou F. The Long non-coding RNA TP73-AS1 interacted with miR-142 to modulate brain glioma growth through HMGB1/RAGE pathway[J]. J Cell Biochem, 2018, 119(4):3007-3016.
[12] Wang D, Plukker JTM, Coppes RP. Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer[J]. Semin Cancer Biol, 2017, 44:60-66.
[13] Hou X, Wen J, Ren Z, et al. Non-coding RNAs: new biomarkers and therapeutic targets for esophageal cancer[J]. Oncotarget, 2017, 8(26):43571-43578.
[14] Zang W, Wang T, Wang Y, et al. Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma[J]. Oncotarget, 2016, 7(15):19960-19974.
[15] 张会瑞, 焦军东. lncRNA TP73-AS1对肝细胞癌细胞HepG-2凋亡的影响及其机制[J]. 实用药物与临床, 2016, 19(8):929-932.
[16] Li S, Huang Y, Huang Y, et al. The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation[J]. J Exp Clin Cancer Res, 2017, 36(1):51.
[17] Yao Y, Sun Y, Jiang Y, et al. Enhanced expression of lncRNA TP73-AS1 predicts adverse phenotypes for cholangiocarcinoma and exerts oncogenic properties in vitro and in vivo[J]. Biomed Pharmacother, 2018, 106:260-266.
[18] Cai Y, Yan P, Zhang G, et al. Long non-coding RNA TP73-AS1 sponges miR-194 to promote colorectal cancer cell proliferation, migration and invasion via up-regulating TGFα[J]. Cancer Biomark, 2018, 23(1):145-156.
[19] Wang Y, Xiao S, Wang B, et al. Knockdown of lncRNA TP73-AS1 inhibits gastric cancer cell proliferation and invasion via the WNT/β-catenin signaling pathway[J]. Oncol Lett, 2018, 16(3):3248-3254.
[20] Ding Z, Lan H, Xu R, et al. LncRNA TP73-AS1 accelerates tumor progression in gastric cancer through regulating miR-194-5p/SDAD1 axis[J]. Pathol Res Pract, 2018, 214(12):1993-1999.
[21] Zhang W, Zhai Y, Wang W, et al. Enhanced expression of lncRNA TP73-AS1 predicts unfavorable prognosis for gastric cancer and promotes cell migration and invasion by induction of EMT[J]. Gene, 2018, 678:377-383.
[22] 李冠军, 亚国伟, 唐正严, 等. miR-153靶向PRDM2基因并通过JAK/STAT信号通路影响膀胱癌的侵袭和迁移[J]. 中国病理生理杂志, 2018, 34(1):58-63.
[23] Tuo Z, Zhang J, Xue W. LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway[J]. Biochem Biophys Res Commun, 2018, 499(4):875-881.
[24] Liu G, Zhao X, Zhou J, et al. LncRNA TP73-AS1 promotes cell proliferation and inhibits cell apoptosis in clear cell renal cell carcinoma through repressing KISS1 expression and inactivation of PI3K/Akt/mTOR signaling pathway[J]. Cell Physiol Biochem, 2018, 48(1):371-384.
[25] Li L, Gan ZH, Qin L, et al. AIB1 regulates the ovarian cancer cell cycle through TUG1[J]. Eur Rev Med Pharmacol Sci, 2017, 21(24):5610-5617.
[26] Wang X, Yang B, She Y, et al. The lncRNA TP73-AS1 promotes ovarian cancer cell proliferation and metastasis via modulation of MMP2 and MMP9[J]. J Cell Biochem, 2018, 119(9):7790-7799.
[27] 裴振, 霍小蕾, 田向阳, 等. 长链非编码RNA MIAT在非小细胞肺癌中的表达及功能研究[J]. 中国病理生理杂志, 2018, 34(4):592-598.
[28] Zhang L, Fang F, He X. Long noncoding RNA TP73-AS1 promotes non-small cell lung cancer progression by competitively sponging miR-449a/EZH2[J]. Biomed Pharmacother, 2018, 104:705-711.
[29] Liu C, Ren L, Deng J, et al. LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway[J]. Biosci Rep, 2019, 39(1):BSR20180999.
[30] Zou Q, Zhou E, Xu F, et al. A TP73-AS1/miR-200a/ZEB1 regulating loop promotes breast cancer cell invasion and migration[J]. J Cell Biochem, 2018, 119(2):2189-2199.
[31] Yao J, Xu F, Zhang D, et al. TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition[J]. J Cell Biochem, 2018, 119(1):680-690.
[32] Tao W, Sun W, Zhu H, et al. Knockdown of long non-coding RNA TP73-AS1 suppresses triple negative breast cancer cell vasculogenic mimicry by targeting miR-490-3p/TWIST1 axis[J]. Biochem Biophys Res Commun, 2018, 504(4):629-634.
[33] Yang G, Song R, Wang L, et al. Knockdown of long non-coding RNA TP73-AS1 inhibits osteosarcoma cell proliferation and invasion through sponging miR-142[J]. Biomed Pharmacother, 2018, 103:1238-1245.
[34] Hu H, Liu JM, Hu Z, et al. Recently evolved tumor suppressor transcript TP73-AS1 functions as sponge of human-specific miR-941[J]. Mol Biol Evol, 2018, 35(5):1063-1077.
[35] Peng J. si-TP73-AS1 suppressed proliferation and increased the chemotherapeutic response of GC cells to cisplatin[J]. Oncol Lett, 2018, 16(3):3706-3714.
[2] 覃伟峰, 仉红刚. lncRNA在心血管疾病中作用的研究进展[J]. 中国病理生理杂志, 2016, 32(8):1471-1477.
[3] Zhou M, Wang X, Shi H, et al. Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer[J]. Oncotarget, 2016, 7(11):12598-12611.
[4] 张明娇, 吴勇, 李珉珉. 长链非编码RNAs的生物功能及其与器官发育和恶性肿瘤的关系[J]. 中国病理生理杂志, 2015, 31(11):2107-2112.
[5] 李正龙, 徐艺, 冷开明, 等. 长链非编码RNA SOX2OT在肿瘤中的调控作用及对预后的影响[J]. 现代肿瘤医学, 2018, 26(14):2290-2293.
[6] Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism[J]. Bioessays, 2016, 38(10):991-996.
[7] Xiao S, Wang R, Wu X, et al. The long noncoding RNA TP73-AS1 interacted with miR-124 to modulate glioma growth by targeting inhibitor of apoptosis-stimulating protein of p53[J]. DNA Cell Biol, 2018, 37(2):117-125.
[8] Dominguez G, Garcia JM, Pena C, et al. DeltaTAp73 upregulation correlates with poor prognosis in human tumors:putative in vivo network involving p73 isoforms, p53, and E2F-1[J]. J Clin Oncol, 2006, 24(5):805-815.
[9] Zitterbart K, Zavrelova I, Kadlecova J, et al. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival[J]. Acta Neuropathol, 2007, 114(6):641-650.
[10] Wang JB, Liu FH, Chen JH, et al. Identifying survival-associated modules from the dysregulated triplet network in glioblastoma multiforme[J]. J Cancer Res Clin Oncol, 2017, 143(4):661-671.
[11] Zhang R, Jin H, Lou F. The Long non-coding RNA TP73-AS1 interacted with miR-142 to modulate brain glioma growth through HMGB1/RAGE pathway[J]. J Cell Biochem, 2018, 119(4):3007-3016.
[12] Wang D, Plukker JTM, Coppes RP. Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer[J]. Semin Cancer Biol, 2017, 44:60-66.
[13] Hou X, Wen J, Ren Z, et al. Non-coding RNAs: new biomarkers and therapeutic targets for esophageal cancer[J]. Oncotarget, 2017, 8(26):43571-43578.
[14] Zang W, Wang T, Wang Y, et al. Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma[J]. Oncotarget, 2016, 7(15):19960-19974.
[15] 张会瑞, 焦军东. lncRNA TP73-AS1对肝细胞癌细胞HepG-2凋亡的影响及其机制[J]. 实用药物与临床, 2016, 19(8):929-932.
[16] Li S, Huang Y, Huang Y, et al. The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation[J]. J Exp Clin Cancer Res, 2017, 36(1):51.
[17] Yao Y, Sun Y, Jiang Y, et al. Enhanced expression of lncRNA TP73-AS1 predicts adverse phenotypes for cholangiocarcinoma and exerts oncogenic properties in vitro and in vivo[J]. Biomed Pharmacother, 2018, 106:260-266.
[18] Cai Y, Yan P, Zhang G, et al. Long non-coding RNA TP73-AS1 sponges miR-194 to promote colorectal cancer cell proliferation, migration and invasion via up-regulating TGFα[J]. Cancer Biomark, 2018, 23(1):145-156.
[19] Wang Y, Xiao S, Wang B, et al. Knockdown of lncRNA TP73-AS1 inhibits gastric cancer cell proliferation and invasion via the WNT/β-catenin signaling pathway[J]. Oncol Lett, 2018, 16(3):3248-3254.
[20] Ding Z, Lan H, Xu R, et al. LncRNA TP73-AS1 accelerates tumor progression in gastric cancer through regulating miR-194-5p/SDAD1 axis[J]. Pathol Res Pract, 2018, 214(12):1993-1999.
[21] Zhang W, Zhai Y, Wang W, et al. Enhanced expression of lncRNA TP73-AS1 predicts unfavorable prognosis for gastric cancer and promotes cell migration and invasion by induction of EMT[J]. Gene, 2018, 678:377-383.
[22] 李冠军, 亚国伟, 唐正严, 等. miR-153靶向PRDM2基因并通过JAK/STAT信号通路影响膀胱癌的侵袭和迁移[J]. 中国病理生理杂志, 2018, 34(1):58-63.
[23] Tuo Z, Zhang J, Xue W. LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway[J]. Biochem Biophys Res Commun, 2018, 499(4):875-881.
[24] Liu G, Zhao X, Zhou J, et al. LncRNA TP73-AS1 promotes cell proliferation and inhibits cell apoptosis in clear cell renal cell carcinoma through repressing KISS1 expression and inactivation of PI3K/Akt/mTOR signaling pathway[J]. Cell Physiol Biochem, 2018, 48(1):371-384.
[25] Li L, Gan ZH, Qin L, et al. AIB1 regulates the ovarian cancer cell cycle through TUG1[J]. Eur Rev Med Pharmacol Sci, 2017, 21(24):5610-5617.
[26] Wang X, Yang B, She Y, et al. The lncRNA TP73-AS1 promotes ovarian cancer cell proliferation and metastasis via modulation of MMP2 and MMP9[J]. J Cell Biochem, 2018, 119(9):7790-7799.
[27] 裴振, 霍小蕾, 田向阳, 等. 长链非编码RNA MIAT在非小细胞肺癌中的表达及功能研究[J]. 中国病理生理杂志, 2018, 34(4):592-598.
[28] Zhang L, Fang F, He X. Long noncoding RNA TP73-AS1 promotes non-small cell lung cancer progression by competitively sponging miR-449a/EZH2[J]. Biomed Pharmacother, 2018, 104:705-711.
[29] Liu C, Ren L, Deng J, et al. LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway[J]. Biosci Rep, 2019, 39(1):BSR20180999.
[30] Zou Q, Zhou E, Xu F, et al. A TP73-AS1/miR-200a/ZEB1 regulating loop promotes breast cancer cell invasion and migration[J]. J Cell Biochem, 2018, 119(2):2189-2199.
[31] Yao J, Xu F, Zhang D, et al. TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition[J]. J Cell Biochem, 2018, 119(1):680-690.
[32] Tao W, Sun W, Zhu H, et al. Knockdown of long non-coding RNA TP73-AS1 suppresses triple negative breast cancer cell vasculogenic mimicry by targeting miR-490-3p/TWIST1 axis[J]. Biochem Biophys Res Commun, 2018, 504(4):629-634.
[33] Yang G, Song R, Wang L, et al. Knockdown of long non-coding RNA TP73-AS1 inhibits osteosarcoma cell proliferation and invasion through sponging miR-142[J]. Biomed Pharmacother, 2018, 103:1238-1245.
[34] Hu H, Liu JM, Hu Z, et al. Recently evolved tumor suppressor transcript TP73-AS1 functions as sponge of human-specific miR-941[J]. Mol Biol Evol, 2018, 35(5):1063-1077.
[35] Peng J. si-TP73-AS1 suppressed proliferation and increased the chemotherapeutic response of GC cells to cisplatin[J]. Oncol Lett, 2018, 16(3):3706-3714.