摘要
目的探讨卵泡液FOXL2在超促排卵周期中与卵巢对外源性促性腺激素(Gn)反应的相关性。方法将231例长方案超促排卵周期治疗的不孕患者按照Gn用量分为4组,A组(<2 000 IU)、B组(2 000~2999 IU)、C组(3 001~3 999 IU)、D组(≥4 000 IU)。收集患者卵泡液采用ELISA双抗体夹心法检测FOXL2的浓度。结果随着Gn用量的增加,卵泡液FOXL2表达逐渐降低,组间差异有统计学意义(P<0.05)。各组间Gn用量越高,患者优质胚胎率越低,差异有统计学意义(P<0.05)。临床妊娠率随Gn用量增加呈下降趋势,由于样本量限制,差异无统计学意义。结论超促排卵周期卵泡液FOXL2水平与卵巢反应性呈正相关。高水平的FOXL2可能预示着更好的临床结局。
Objective To investigate the correlation between FOXL2 level in follicular fluid and ovary response to exogenous gonadotropins( Gn) during controlled ovarian hyperstimulation. Methods Totally 231 infertile patients,who received the treatment of controlled ovarian stimulation( COH),were divided into four groups based on the dose of exogenouse gonadotropins,Group A( < 2 000 IU),Group B( 2 000-2 999 IU),Group C( 3 000-3 999 IU) and Group D( ≥4 000 IU). Follicular fluid( FF) were collected during oocytes retrieval. The levels of FOXL2 in FF samples were assessed by double-antibody sandwich ELISA. Results FOXL2 level in follicular was significantly positively correlated with Gn dose( P < 0. 05). Among these four groups,significantly higher live birth rate and high-quality embryonic rate were obtained in lower Gn dose group( P < 0. 05). Conclusion FOXL2 in FF is good marker to predict the ovarian response and the COH outcome.
引文
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