经穴导入加味逍遥蒌贝散治疗肝郁痰凝型乳腺增生症临床研究
|
摘要
目的:观察经穴导入加味逍遥蒌贝散治疗肝郁痰凝型乳腺增生症的临床疗效。方法:将60例肝郁痰凝型乳腺增生症患者随机分为治疗组和对照组各30例。治疗组给予经穴导入加味逍遥蒌贝散治疗,对照组给予枸橼酸他莫昔芬片口服。观察2组治疗前后乳腺症状积分、伴随症状积分和激素水平的变化。结果:治疗组治愈率33.3%,总有效率96.7%;对照组治愈率10.0%,总有效率93.3%。治疗组治愈率高于对照组,差异有统计学意义(P <0.05)。2组总有效率比较,差异无统计学意义(P> 0.05)。治疗后,2组乳腺疼痛、肿块硬度及肿块大小积分均较治疗前降低(P <0.05),治疗组3项乳腺症状积分均低于对照组(P <0.05)。治疗后,2组胸闷胁胀、善郁易怒、失眠多梦、心烦口苦积分均较治疗前降低(P <0.05),治疗组4项伴随症状积分均低于对照组(P <0.05)。治疗后,2组血清雌二醇(E2)、泌乳素(PRL)水平均较治疗前降低(P <0.05);组间E2及PRL水平比较,差异均无统计学意义(P> 0.05)。2组治疗过程中均无不良反应发生。结论:经穴导入加味逍遥蒌贝散可有效改善肝郁痰凝型乳腺增生患者的临床症状,无明显不良反应,其作用机制可能与调节激素水平有关。
Objective: To observe the clinical effect of acupoint lontophoresis of modified Xiaoyao Loubei powder for mastoplasia of liver-depression and phlegm-congealing type. Methods: Divided 60 cases of patients with mastoplasia of liver-depression and phlegm-congealing type into the treatment group and the control group randomly, 30 cases in each group. The control group received tamoxifen citrate tablets via oral administration, while the treatment group received acupoint lontophoresis of modified Xiaoyao Loubei powder. Observed the changes of symptom scores of mastoplasia,scores of concomitant symptoms and levels of hormone in both groups before and after treatment. Results:The cure rate was 33.3%in the treatment group, being higher than 10.0% in the control group, difference being significant(P < 0.05); the total effective rate was 96.7% in the treatment group and 93.3% in the control group,difference being insignificant(P > 0.05). After treatment,scores of mammalgia,hardness and size of breast mass in both groups were lower than those before treatment(P < 0.05),and each score above in the treatment group was respectively lower than that in the control group(P < 0.05). After treatment, scores of chest distress, rib-side distention, tendency to be depressed and irritable, insomnia, dreaminess,upset mind and bitter mouth in both groups were lower than those before treatment(P < 0.05),and each score above in the treatment group was respectively lower than that in the control group(P < 0.05). After treatment,the levels of estradiol(E2)and prolactin(PRL)in both groups were lower than those before treatment(P < 0.05);comparing each index above in-between the two groups,there were no significant differences being found(P > 0.05). No adverse reactions occurred in both groups during treatment. Conclusion: Acupoint lontophoresis of modified Xiaoyao Loubei powder can effectively improve the clinical symptoms of patients with mastoplasia of liver-depression and phlegm-congealing type without significant adverse reactions.Its functional mechanism may be related to regulating the levels of hormone in body.
Objective: To observe the clinical effect of acupoint lontophoresis of modified Xiaoyao Loubei powder for mastoplasia of liver-depression and phlegm-congealing type. Methods: Divided 60 cases of patients with mastoplasia of liver-depression and phlegm-congealing type into the treatment group and the control group randomly, 30 cases in each group. The control group received tamoxifen citrate tablets via oral administration, while the treatment group received acupoint lontophoresis of modified Xiaoyao Loubei powder. Observed the changes of symptom scores of mastoplasia,scores of concomitant symptoms and levels of hormone in both groups before and after treatment. Results:The cure rate was 33.3%in the treatment group, being higher than 10.0% in the control group, difference being significant(P < 0.05); the total effective rate was 96.7% in the treatment group and 93.3% in the control group,difference being insignificant(P > 0.05). After treatment,scores of mammalgia,hardness and size of breast mass in both groups were lower than those before treatment(P < 0.05),and each score above in the treatment group was respectively lower than that in the control group(P < 0.05). After treatment, scores of chest distress, rib-side distention, tendency to be depressed and irritable, insomnia, dreaminess,upset mind and bitter mouth in both groups were lower than those before treatment(P < 0.05),and each score above in the treatment group was respectively lower than that in the control group(P < 0.05). After treatment,the levels of estradiol(E2)and prolactin(PRL)in both groups were lower than those before treatment(P < 0.05);comparing each index above in-between the two groups,there were no significant differences being found(P > 0.05). No adverse reactions occurred in both groups during treatment. Conclusion: Acupoint lontophoresis of modified Xiaoyao Loubei powder can effectively improve the clinical symptoms of patients with mastoplasia of liver-depression and phlegm-congealing type without significant adverse reactions.Its functional mechanism may be related to regulating the levels of hormone in body.
引文
[1]王桂玲.女性乳腺疾病流行病学调查分析[J].中国当代医药,2011,18(29):168-169.
[2]廖明娟,蒉纲,王永灵,等.中医药治疗乳腺增生病随机对照试验的Meta分析[J].中国中医药信息杂志,2010,17(10):17-20.
[3]刘玉斌,李德辉,张素燚,等.中医外治疗法与内治疗法治疗乳腺增生症疗效差异的meta分析[J].中国老年学杂志,2013,33(7):1489-1491.
[4]林毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:107-108.
[5]李曰庆.中医外科学[M].2版.北京:中国中医药出版社,2007:114.
[6]唐汉钧.乳腺病研究新进展[M].上海:上海中医药大学出版社,2004:298.
[7]曹韧楠,朱春燕.中药透皮吸收促渗方法的研究进展[J].中国中药杂志,2007,32(1):18-20.
[2]廖明娟,蒉纲,王永灵,等.中医药治疗乳腺增生病随机对照试验的Meta分析[J].中国中医药信息杂志,2010,17(10):17-20.
[3]刘玉斌,李德辉,张素燚,等.中医外治疗法与内治疗法治疗乳腺增生症疗效差异的meta分析[J].中国老年学杂志,2013,33(7):1489-1491.
[4]林毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:107-108.
[5]李曰庆.中医外科学[M].2版.北京:中国中医药出版社,2007:114.
[6]唐汉钧.乳腺病研究新进展[M].上海:上海中医药大学出版社,2004:298.
[7]曹韧楠,朱春燕.中药透皮吸收促渗方法的研究进展[J].中国中药杂志,2007,32(1):18-20.