3D打印水溶性聚乙烯醇材料的研究与应用
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摘要
对3D打印水溶性聚乙烯醇(PVA)材料的研究做了全面的综述。介绍了PVA材料的制备方法;重点综述了3D打印水溶性PVA在组织工程支架材料、药物装载材料、水溶性支撑材料以及可溶模具材料方面的研究与应用;并讨论了3D打印水溶性PVA材料存在的问题与未来的发展前景。
The research of 3D printing water-soluble polyvinyl alcohol(PVA)material was comprehensively reviewed.The synthesis method of PVA was introduced,the research and application of 3D printing water-soluble PVA in tissue engineer scaffold materials,drug loading materials,water-soluble supporting materials and soluble mold materials aspects were described in detail.Finally,the current problems and future development prospects of 3D printing water-soluble PVA were discussed.
The research of 3D printing water-soluble polyvinyl alcohol(PVA)material was comprehensively reviewed.The synthesis method of PVA was introduced,the research and application of 3D printing water-soluble PVA in tissue engineer scaffold materials,drug loading materials,water-soluble supporting materials and soluble mold materials aspects were described in detail.Finally,the current problems and future development prospects of 3D printing water-soluble PVA were discussed.
引文
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[20]Duran C,Subbian V,Giovanetti M T,et al.Experimental desktop 3Dprinting using dual extrusion and water-soluble polyvinyl alcohol[J].Rapid Prototyping Journal,2015,21(5):528-534.
[21]Ni F,Wang G,Zhao H.Fabrication of water-soluble polyvinyl alcohol-based composites with improved thermal behavior for potential three-dimensional printing application[J].Journal of Applied Polymer Science,2017,134(24):44966-44973.
[22]陈涛,万熠,史振宇,等.基于三维扫描和3D打印的鼻套模具制作关键技术[J].工具技术,2017,51(7):42-45.
[23]Mohanty S,Larsen L B,Trifol J,et al.Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3Dprinted moulds[J].Materials Science and Engineering C,2015,55:569-578.
[2]Dul S,Fambri L,Pegoretti A.Fused deposition modelling with ABS-graphene nanocomposites[J].Composites A,2016,85:181-191.
[3]刘利刚,徐文鹏,王伟明,等.3D打印中的几何计算研究进展[J].计算机学报,2015,38(6):1243-1267.
[4]罗文峰,杨雪香,敖宁建.生物医用材料的3D打印技术与发展[J].材料导报,2016,30(13):81-86.
[5]刘红宇,郑英丽,彭淑鸽,等.PVA/石墨烯复合材料研究进展[J].化工新型材料,2014,42(11):1-3.
[6]周琦琪,韩祥祯,宋艳艳,等.3D打印羊椎骨粉/聚乙烯醇支架、纳米级羟基磷灰石/聚乙烯醇支架、羊椎骨粉/聚乙烯醇无孔骨板的性能比较[J].中国组织工程研究,2016,20(52):7851-7857.
[7]苏宏艺,陈威,陈大智,等.3D打印制模精密铸造成形钴铬钼人造股骨头技术[J].热加工工艺,2015,44(19):103-105.
[8]雷春堂,潘晓勇,姚国红,等.水溶性聚乙烯醇的研究进展[J].塑料工业,2011,39(2):10-13.
[9]金嘉长,王扬,马维虎,等.3D生物打印技术在组织工程支架构建与再生中的应用进展[J].航天医学与医学工程,2016,29(6):462-468.
[10]Gauvin R,Chen Y C,Lee J W,et al.Microfabrication of complex porous tissue engineering scaffolds using 3Dprojection stereolithography[J].Biomaterials,2012,33(15):3824-3834.
[11]李坚,李学锋,龙世军,等.3D成型SiO2/PVA水凝胶支架的摩擦行为[J].复合材料学报,2016,33(11):2412-2418.
[12]Li J,He L,Zhou C,et al.3Dprinting for regenerative medicine:from bench to bedside[J].Mrs Bulletin,2015,40(2):145-154.
[13]Hikita A,Chung U I,Hoshi K,et al.Bone regenerative medicine in oral and maxillofacial region using a 3Dprinter[J].Tissue Engineering Part A,2017,23(11):515-521.
[14]Angjellari M,Tamburri E,Montaina L,et al.Beyond the concepts of nanocomposite and 3Dprinting:PVA and nanodiamonds for layer-by-layer additive manufacturing[J].Materials and Design,2017,119:12-21.
[15]Goyanes A,Kobayashi M,Martínez-Pacheco R,et al.Fusedfilament 3Dprinting of drug products:microstructure analysis and drug release characteristics of PVA-based caplets[J].International Journal of Pharmaceutics,2016,514(1):290-295.
[16]Goyanes A,Robles M P,Buanz A,et al.Effect of geometry on drug release from 3Dprinted tablets[J].International Journal of Pharmaceutics,2015,494(2):657-663.
[17]Skowyra J,Pietrzak K,Alhnan M A.Fabrication of extendedrelease patient-tailored prednisolone tablets via fused deposition modelling(FDM)3Dprinting[J].European Journal of Pharmaceutical Sciences,2015,68:11-17.
[18]陈卫.熔融沉积成型用聚乙烯醇支撑丝材的制备及产业化[D].武汉:武汉工程大学,2015.
[19]江献财,董海亚,谢静思,等.聚乙烯醇的热降解及热塑加工改性研究进展[J].高分子通报,2010(10):38-45.
[20]Duran C,Subbian V,Giovanetti M T,et al.Experimental desktop 3Dprinting using dual extrusion and water-soluble polyvinyl alcohol[J].Rapid Prototyping Journal,2015,21(5):528-534.
[21]Ni F,Wang G,Zhao H.Fabrication of water-soluble polyvinyl alcohol-based composites with improved thermal behavior for potential three-dimensional printing application[J].Journal of Applied Polymer Science,2017,134(24):44966-44973.
[22]陈涛,万熠,史振宇,等.基于三维扫描和3D打印的鼻套模具制作关键技术[J].工具技术,2017,51(7):42-45.
[23]Mohanty S,Larsen L B,Trifol J,et al.Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3Dprinted moulds[J].Materials Science and Engineering C,2015,55:569-578.