α-磷酸三钙对磷酸镁骨水泥强度与体外降解性能的影响
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摘要
为探究α-磷酸三钙(α-TCP)对MPC强度和体外降解性能的影响,将α-TCP与MPC复合制得α-TCP/MPC骨水泥样品,然后将样品分别置于去离子水、模拟体液(SBF)及磷酸盐缓冲溶液(PBS)中浸泡不同周期,通过万能实验机、X射线衍射(XRD)、扫描电子显微镜(SEM)等对α-TCP/MPC骨水泥样品进行测试。结果表明,α-TCP的加入仍可保持MPC优异的力学性能,同时可提高MPC的耐水性,延缓MPC在SBF中的降解速率; SBF浸泡后的α-TCP/MPC样品表面有球状类骨磷灰石生成,表明α-TCP/MPC可能具有良好生物活性。
In order to explore the effect of α-tricalcium phosphate (α-TCP) on the strength and in vitro degradation of MPC,α-TCP was added into the MPC to prepare the α-TCP/MPC cement samples,then the samples were immersed in deionized water,simulated body fluid (SBF) and phosphate buffered saline (PBS) for different ages,the α-TCP/MPC cement samples were tested by universal testing machine,Xray diffraction (XRD) and scanning electron microscopy (SEM). The results show that addition of α-TCP can still maintain the MPC excellent mechanical properties,while it also can improve the water resistance of MPC and reduce the degradation rate of MPC in SBF. The surface of α-TCP/MPC after soaking has spherical bone-like apatite formation. It is show that α-TCP/MPC may have good biological activity.
In order to explore the effect of α-tricalcium phosphate (α-TCP) on the strength and in vitro degradation of MPC,α-TCP was added into the MPC to prepare the α-TCP/MPC cement samples,then the samples were immersed in deionized water,simulated body fluid (SBF) and phosphate buffered saline (PBS) for different ages,the α-TCP/MPC cement samples were tested by universal testing machine,Xray diffraction (XRD) and scanning electron microscopy (SEM). The results show that addition of α-TCP can still maintain the MPC excellent mechanical properties,while it also can improve the water resistance of MPC and reduce the degradation rate of MPC in SBF. The surface of α-TCP/MPC after soaking has spherical bone-like apatite formation. It is show that α-TCP/MPC may have good biological activity.
引文
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[18]Zheng D D,Ji T,Wang C Q,et al.Effect of the combination of fly ash and silica fume on water resistance of Magnesium-Potassium Phosphate Cement[J].Construction and Building Materials,2016,106:415-421.
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[20]刘健休,沈莹,储彬,等.-种可注射生物活性磷酸钙骨修复材料的制备及表征[J].中国组织工程研究,2017,21(6):821-828.
[21]Ma H,Xu B.Potential to design magnesium potassium phosphate cement paste based on an optimal magne-sia-to-phosphate ratio[J].Materials&Design,2017,118:81-88.
[22]高昊辰,吴鉴今,曹志中.磷酸钙骨水泥生物学特性及在口腔学应用中的研究进展[J].医学研究生学报,2015,28(8):880-884.
[23]韩要丛,崔学民,昝青峰,等.α-TCP水化生成羟基磷灰石机理及其应用研究进展[J].材料导报,2010,24(13):62-66.
[24]宋宏杰,梁星,骆筱秋,等.α-磷酸三钙骨水泥修复骨缺损及其降解物诱导成骨的实验研究[J].四川大学学报(医学版),2005,36(6):847-849.
[25]Martinez I M,Velasquezp,Meseguer-Olmo L,et al.Preparation and characterization of novel bioac-tiveα-tricalcium phosphate doped with dicalcium silicate ceramics[J].Materials Science and Engineering C,2012,32(4):878-886.
[26]Durucan C,Brown P.alpha-Tricalcium phosphate hydrolysis to hydroxyapatite at and near physiological temperature[J].Journal of Materials Science Materials in Medicine,2000,11(6):365-371.
[27]李鸿,南景天,吕国玉,等.新型可降解α-TCP/多元氨基酸共聚物复合材料制备与表征[J].复合材料学报,2010,27(4):26-30.
[28]殷桂华,韩泽民.磷酸钙骨水泥在骨缺损修复中的应用[J].中国康复理论与实践,2011,17(12):1139-1141.
[29]李茂红,姚宁,屈树新.提高磷酸钙骨水泥抗压强度的方法及相关机理[J].材料导报,2014,28(23):86-90.
[30]Vásquez A F,Domínguez S,La L D S.α-TCP cements prepared by syringe-foaming:influence of Na2HPO4and surfactant concentration[J].Materials Science&Engineering C,2017,81:148-155.
[31]窦妍,李东旭,曹丰,等.羟基磷灰石微球制备方法的研究进展[J].材料导报,2010,24(s2):417-419.
[32]Zhu K P,Sun J,Ye S,et al.A novel hollow hydroxyapatite microspheres/chitosan composite drug carrier for controlled release[J].Journal of Inorganic Materials,2016,31(4):434-442.
[2]李涛,胡夏闽,杨建明,等.磷酸钾镁水泥基材料与硅酸盐水泥混凝土的粘结性能研究[J].硅酸盐通报,2015,34(8):2144-2150.
[3]Li Y,Bai W,Shi T.A study of the bonding performance of magnesium phosphate cement on mortar and concrete[J].Construction and Building Materials,2017,142:459-468.
[4]Lu Z,Hou D,Ma H,et al.Effects of graphene oxide on the properties and microstructures of the magnesium potassium phosphate cement paste[J].Construction and Building Materials,2016,119:107-112.
[5]侯磊,李金洪,王浩林.矿渣磷酸镁水泥的力学性能和水化机理[J].岩石矿物学杂志,2011,30(4):721-726.
[6]Li G,Zhang J,Zhang G.Mechanical property and water stability of the novel CSA-MKPC blended system[J].Construction and Building Materials,2017,136:99-107.
[7]Zhou H,Agarwal A K,Goel VK,et al.Microwave assisted preparation of magnesium phosphate cement(MPC)for orthopedic applications:A novel solution to the exothermicity problem[J].Materials Science and En-gineering:C,2013,33(7):4288-4294.
[8]Ma C,Chen B.Experimental study on the preparation and properties of a novel foamed concrete based on mag-nesium phosphate cement[J].Construction and Building Materials,2017,137:160-168.
[9]张秉文,俞永林,刘昌胜,等.磷酸镁骨黏合剂的生物安全性研究[J].中华医院感染学杂志,2011,21(7):1297-1300.
[10]马安博,赵娜娜.磷酸镁生物骨水泥固化时间影响因素分析[J].新技术新工艺,2015(8):102-105.
[11]Czechowska J,Zima A,Paszkiewicz Z,et al.Physicochemical properties and biomimetic behaviour ofα-TCP-chitosan based materials[J].Ceramics International,2014,40(4):5523-5532.
[12]Bahaie E,Lin B,Bhaduri S B.A new method to produce macroporous Mg-phosphate bone growth substi-tutes[J].Materials Science and Engineering:C,2017,75:602-609.
[13]Cabrejos-Azama J,Alkhraisat M H,Rueda C,et al.Magnesium substitution in brushite ce-ments:efficacy of a new biomaterial loaded with vancomycin for the treatment of Staphylococcus aureus infections[J].Materials Science and Engineering:C,2016,61:72-78.
[14]Liu W,Zhai D,Huan Z,et al.Novel tricalcium silicate/magnesium phosphate composite bone cement having high compressive strength,in vitro bioactivity and cytocompatibility[J].Acta Biomaterialia,2015,21:217-227.
[15]Yang G,Liu J,Li F,et al.Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications[J].Materials Science and Engineering:C,2014,35:70-76.
[16]丁耀堃,王哲,许四法,等.矿渣对磷酸镁水泥耐水性能的影响[J].科技通报,2016,32(10):76-81.
[17]Zhang G,Li G,He T.Effects of sulphoaluminate cement on the strength and water stability of magnesium potassium phosphate cement[J].Construction and Building Materials,2017,132:335-342.
[18]Zheng D D,Ji T,Wang C Q,et al.Effect of the combination of fly ash and silica fume on water resistance of Magnesium-Potassium Phosphate Cement[J].Construction and Building Materials,2016,106:415-421.
[19]邱耿韬,史占军,赵亮.磷酸钙骨水泥在骨组织再生修复应用中的研究进展[J].中国矫形外科杂志,2013,21(14):1406-1409.
[20]刘健休,沈莹,储彬,等.-种可注射生物活性磷酸钙骨修复材料的制备及表征[J].中国组织工程研究,2017,21(6):821-828.
[21]Ma H,Xu B.Potential to design magnesium potassium phosphate cement paste based on an optimal magne-sia-to-phosphate ratio[J].Materials&Design,2017,118:81-88.
[22]高昊辰,吴鉴今,曹志中.磷酸钙骨水泥生物学特性及在口腔学应用中的研究进展[J].医学研究生学报,2015,28(8):880-884.
[23]韩要丛,崔学民,昝青峰,等.α-TCP水化生成羟基磷灰石机理及其应用研究进展[J].材料导报,2010,24(13):62-66.
[24]宋宏杰,梁星,骆筱秋,等.α-磷酸三钙骨水泥修复骨缺损及其降解物诱导成骨的实验研究[J].四川大学学报(医学版),2005,36(6):847-849.
[25]Martinez I M,Velasquezp,Meseguer-Olmo L,et al.Preparation and characterization of novel bioac-tiveα-tricalcium phosphate doped with dicalcium silicate ceramics[J].Materials Science and Engineering C,2012,32(4):878-886.
[26]Durucan C,Brown P.alpha-Tricalcium phosphate hydrolysis to hydroxyapatite at and near physiological temperature[J].Journal of Materials Science Materials in Medicine,2000,11(6):365-371.
[27]李鸿,南景天,吕国玉,等.新型可降解α-TCP/多元氨基酸共聚物复合材料制备与表征[J].复合材料学报,2010,27(4):26-30.
[28]殷桂华,韩泽民.磷酸钙骨水泥在骨缺损修复中的应用[J].中国康复理论与实践,2011,17(12):1139-1141.
[29]李茂红,姚宁,屈树新.提高磷酸钙骨水泥抗压强度的方法及相关机理[J].材料导报,2014,28(23):86-90.
[30]Vásquez A F,Domínguez S,La L D S.α-TCP cements prepared by syringe-foaming:influence of Na2HPO4and surfactant concentration[J].Materials Science&Engineering C,2017,81:148-155.
[31]窦妍,李东旭,曹丰,等.羟基磷灰石微球制备方法的研究进展[J].材料导报,2010,24(s2):417-419.
[32]Zhu K P,Sun J,Ye S,et al.A novel hollow hydroxyapatite microspheres/chitosan composite drug carrier for controlled release[J].Journal of Inorganic Materials,2016,31(4):434-442.