冠心病合并代谢综合征患者血清载脂蛋白B、A1及其比值与冠状动脉病变程度的关系
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摘要
目的观察冠心病合并代谢综合征(MS)患者血清载脂蛋白B、A1及其比值与冠状动脉病变特点。方法选取2016年9月-2017年11月行冠状动脉造影并确诊为冠心病的患者214例,其中合并MS患者94例(MS组),不合并MS患者120例(非MS组)。MS组根据病变支数分为单支病变亚组和多支病变亚组,分析血清载脂蛋白(Apo)B和ApoA1及ApoB/ApoA1与冠状动脉病变程度的关系。结果 MS组与非MS组高血压、TG、HDL-C、ApoA1、ApoB水平及ApoB/ApoA1比较差异均有统计学意义(P<0.05);MS组多支病变亚组ApoB水平高于单支病变亚组,ApoA1及ApoB/ApoA1比较差异无统计学意义(P>0.05)。结论血清ApoB水平与冠状动脉病变程度呈正相关,是评价MS的良好参数。
Objective To analyze the relationship between serum apolipoprotein B and A1 ratio and the severity of coronary artery disease in patients with coronary heart disease complicated with metabolic syndrome.Methods 214 patients with coronary heart disease diagnosed by coronary angiography from September 2016 to November 2017 were selected,among them,94 patients(MS group) with MS and 120 patients(non-MS group) who did not have MS.The MS group was divided into a single-vessel disease group and a multi-vessel disease group according to the number of lesions,the relationship between serum apolipoprotein(Apo) B and ApoA1 and ApoB/ApoA1 and the degree of coronary artery disease was analyzed.Results There were significant differences in the levels of hypertension,TG,HDL-C,ApoA1,ApoB and ApoB/ApoA1 between MS group and non-MS group(P<0.05).The level of ApoB of patients with multi-vessel disease in MS group was higher than that of single-vessel disease,there was no significant difference between ApoA1 and ApoB/ApoA1(P>0.05).Conclusion There is a positive correlation between serum ApoB level and the severity of coronary artery disease,ApoB is good parameters for evaluating MS.
Objective To analyze the relationship between serum apolipoprotein B and A1 ratio and the severity of coronary artery disease in patients with coronary heart disease complicated with metabolic syndrome.Methods 214 patients with coronary heart disease diagnosed by coronary angiography from September 2016 to November 2017 were selected,among them,94 patients(MS group) with MS and 120 patients(non-MS group) who did not have MS.The MS group was divided into a single-vessel disease group and a multi-vessel disease group according to the number of lesions,the relationship between serum apolipoprotein(Apo) B and ApoA1 and ApoB/ApoA1 and the degree of coronary artery disease was analyzed.Results There were significant differences in the levels of hypertension,TG,HDL-C,ApoA1,ApoB and ApoB/ApoA1 between MS group and non-MS group(P<0.05).The level of ApoB of patients with multi-vessel disease in MS group was higher than that of single-vessel disease,there was no significant difference between ApoA1 and ApoB/ApoA1(P>0.05).Conclusion There is a positive correlation between serum ApoB level and the severity of coronary artery disease,ApoB is good parameters for evaluating MS.
引文
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[4] 陈思,赵金珍,胡晶,等.apoB与LDL-C评估冠心病风险的临床价值比较[J].南方医科大学学报,2017,37(7):938-942.DOI:10.3969/j.issn.1673-4254.2017.07.15.
[5] 濮田,于海奕,徐明,等.未接受降脂治疗的冠心病患者APOB基因多态性与危险因素的交互作用[J].中华心血管病杂志,2017,45(5):386-392.DOI:10.3760/cma.j.issn.0253-3758.2017.05.005.
[6] 樊刚,王忠,黄磊,等.低密度脂蛋白胆固醇正常人群脂蛋白a和载脂蛋白B/载脂蛋白A-1与冠心病的相关性比较[J].岭南心血管病杂志,2015,21(6):731-734.DOI:10.3969/j.issn.1007-9688.2015.06.02.
[7] 陈晓伟,杨朝宽,高传玉,等.冠心病合并代谢综合征患者血清载脂蛋白B和A1及其比值与冠状动脉病变程度的关系[J].中国急救医学,2011,31(2):132-134.DOI:10.3969/j.issn.1002-1949.2011.02.010.
[8] 李伟聪,何昆仑,武强.冠心病合并代谢综合征患者的脂质和载脂蛋白水平分析[J].解放军医学院学报,2013,34(6):570-572.DOI:10.3969/j.issn.2095-5227.2013.06.010.
[9] 孔祥生.代谢综合征在预测冠心病冠脉病变程度中的价值研究[J].中国农村卫生,2018(10):10-11.DOI:10.3969/j.issn.1674-361X.2018.10.010.
[10] 赵越,钱唯韵,王东,等.代谢综合征联合高尿酸血症评估冠心病发病风险的价值[J].江苏大学学报(医学版),2018,28(5):418-422.DOI:10.13312/j.issn.1671-7783.y180133.