成纤维细胞在心肌梗死后炎症和修复中的作用
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摘要
成纤维细胞由间充质细胞分化而来,广泛分布于各器官结缔组织中。在器官细胞坏死和组织损伤时,损伤区域释放多种细胞因子促进成纤维细胞活化,参与器官炎症和修复过程。心肌梗死发生时,广泛坏死的心肌细胞激活相关信号通路诱发炎性反应并促进成纤维细胞的活化、迁移和分化。成纤维细胞的激活除了可以修复梗死区域维持心脏功能外,又可能造成室壁硬化、功能失常乃至心力衰竭。成纤维细胞的炎症和修复机制在心肌梗死后的治疗和心肌梗死引起的心肌重构中有重要作用。本文就成纤维细胞在心肌梗死后炎症和修复中的作用展开论述。
引文
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19 Liu XH,Pan LL,Deng HY,et al.Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4[J].Free Radic Biol Med,2013,54:93-104
20 Pinto AR,Ilinykh A,Ivey MJ,et al.Revisiting cardiac cellular composition[J].Circ Res,2016,118(3):400-409
21 Ivey MJ,Tallquist MD.Defining the cardiac fibroblast[J].Circ J,2016,80(11):2269-2276
22 Frangogiannis NG.Inflammation in cardiac injury,repair and regeneration[J].Curr Opin Cardiol,2015,30(3):240-245
2 Shinde AV,Frangogiannis NG.Fibroblasts in myocardial infarction:a role in inflammation and repair[J].J Mol Cell Cardiol,2014,70:74-82
3 Tillmanns J,Hoffmann D,Habbaba Y,et al.Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction[J].J Mol Cell Cardiol,2015,87:194-203
4 Souders CA,Bowers SL,Baudino TA.Cardiac fibroblast:the renaissance cell[J].Circ Res,2009,105(12):1164-1176
5 Banerjee I,Fuseler JW,Price RL,et al.Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse[J].Am J Physiol Heart Circ Physiol,2007,293(3):H1883-H1891
6 Deb A,Ubil E.Cardiac fibroblast in development and wound healing[J].J Mol Cell Cardiol,2014,70:47-55
7 Moore-Morris T,Cattaneo P,Puceat M,et al.Origins of cardiac fibroblasts[J].J Mol Cell Cardiol,2016,91:1-5
8 Mann DL.Innate immunity and the failing heart:the cytokine hypothesis revisited[J].Circ Res,2015,116(7):1254-1268
9 Chen W,Frangogiannis NG.Fibroblasts in post-infarction inflammation and cardiac repair[J].Biochim Biophys Acta,2013,1833(4):945-953
10 Van Linthout S,Miteva K,Tschope C.Crosstalk between fibroblasts and inflammatory cells[J].Cardiovasc Res,2014,102(2):258-269
11 Yu M,Wen S,Wang M,et al.TNF-alpha-secreting B cells contribute to myocardial fibrosis in dilated cardiomyopathy[J].J Clin Immunol,2013,33(5):1002-1008
12 Szibor M,Poling J,Warnecke H,et al.Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration[J].Cell Mol Life Sci,2014,71(10):1907-1916
13 Meijers WC,van der Velde AR,Pascual-Figal DA,et al.Galectin-3 and post-myocardial infarction cardiac remodeling[J].Eur J Pharmacol,2015,763(Pt A):115-121
14 Kim KW,Park SH,Kim JC.Fibroblast biology in pterygia[J].Exp Eye Res,2016,142:32-39
15 Francis SS,De Jesus NM,Lindsey ML,et al.The crossroads of inflammation,fibrosis,and arrhythmia following myocardial infarction[J].J Mol Cell Cardiol,2016,91:114-122
16 Kohl P,Gourdie RG.Fibroblast-myocyte electrotonic coupling:does it occur in native cardiac tissue?[J].J Mol Cell Cardiol,2014,70:37-46
17 Gulati A,Jabbour A,Ismail TF,et al.Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy[J].JAMA,2013,309(9):896-908
18 Moore-Morris T,Guimaraes-Camboa N,Yutzey KE,et al.Cardiac fibroblasts:from development to heart failure[J].J Mol Med (Berl),2015,93(8):823-830
19 Liu XH,Pan LL,Deng HY,et al.Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4[J].Free Radic Biol Med,2013,54:93-104
20 Pinto AR,Ilinykh A,Ivey MJ,et al.Revisiting cardiac cellular composition[J].Circ Res,2016,118(3):400-409
21 Ivey MJ,Tallquist MD.Defining the cardiac fibroblast[J].Circ J,2016,80(11):2269-2276
22 Frangogiannis NG.Inflammation in cardiac injury,repair and regeneration[J].Curr Opin Cardiol,2015,30(3):240-245