蝉翼藤根茎中的1个新半萜苷
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摘要
目的研究蝉翼藤Securidaca inappendiculata根茎中的化学成分。方法采用大孔树脂、硅胶柱色谱、中压液相、凝胶色谱以及高效制备液相色谱等手段对蝉翼藤根茎95%乙醇提取物中甲醇部位进行分离纯化,根据所得化合物的理化性质和波谱数据鉴定其结构。结果从蝉翼藤根茎中分离得到5个化合物,分别鉴定为2-methylene-butanoicacid4-O-[(β-Dglucopyranosyl)oxy]-intramol-1,6′-ester(1)、3-甲氧基-4-O-β-D-吡喃葡萄糖基-苯甲酸甲酯(2)、苏式-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧新木脂烷-4-O-β-D-吡喃葡萄糖苷(3)、eucomegastigside A(4)、毛果槭倍半新木脂醇-4″-O-β-D-吡喃葡萄糖苷(5)。结论化合物1为1个新的半萜苷,命名为蝉翼藤萜酸苷D。化合物2～4为首次从远志科植物中分离得到。
Objective To study the chemical constituents from the rhizomes of Securidaca inappendiculata. Methods The concrete exacted by 95% Et OH from the rhizomes of S. inappendiculata was isolated and purified by chromatography on macroporous resin, silica gel, MPLC, gel, preparative HPLC, etc. The structures of the chemical constituents were elucidated by means of physicochemical properties and spectroscopic analysis. Results Five compounds were isolated and identified as 2-methylene-butanoic acid 4-O-[(β-D-glucopyranosyl)oxy]-intramol-1,6′-ester(1), 3-methoxyl-4-O-β-D-glucopyranosyloxy-benzoic acid methyl ester(2), threo-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-D-glucopyranoside(3), eucomegastigside A(4), and acernikol-4″-O-β-D-glucopyranoside(5). Conclusion Compound 1 is a new hemiterpene glycoside named securiterpenoside D, and compounds 2—4 are isolated from Polygalaceae for the first time.
Objective To study the chemical constituents from the rhizomes of Securidaca inappendiculata. Methods The concrete exacted by 95% Et OH from the rhizomes of S. inappendiculata was isolated and purified by chromatography on macroporous resin, silica gel, MPLC, gel, preparative HPLC, etc. The structures of the chemical constituents were elucidated by means of physicochemical properties and spectroscopic analysis. Results Five compounds were isolated and identified as 2-methylene-butanoic acid 4-O-[(β-D-glucopyranosyl)oxy]-intramol-1,6′-ester(1), 3-methoxyl-4-O-β-D-glucopyranosyloxy-benzoic acid methyl ester(2), threo-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-D-glucopyranoside(3), eucomegastigside A(4), and acernikol-4″-O-β-D-glucopyranoside(5). Conclusion Compound 1 is a new hemiterpene glycoside named securiterpenoside D, and compounds 2—4 are isolated from Polygalaceae for the first time.
引文
[1]张丽杰.蝉翼藤根及茎化学成分的研究[D].北京:中国协和医科大学,2005.
[2]王起文,马赟,马程遥,等.蝉翼藤化学成分及药理活性研究进展[J].中成药,2016,38(9):2013-2017.
[3]左坚.蝉翼藤抗风湿活性物质基础及作用机制研究[D].南京:南京中医药大学,2015.
[4]李勇文.五味藤的抗炎免疫镇痛作用研究及机制初探[D].南宁:广西医科大学,2005.
[5]李勇文,李丽,李植飞,等.蝉翼藤对小鼠脾细胞体外增殖和淋巴因子分泌水平的影响[J].中国中医药信息杂志,2006,13(5):42-43.
[6]张连涛,梁贤栋,周文亮,等.蝉翼藤有机酸提取物抑制鸭体内乙型肝炎病毒复制及保肝作用的研究[J].中华临床医师杂志,2013(23):10766-10769.
[7]贺兰云,黄海疆.红茴香甲醇部位化学成分研究[J].中国中药杂志,2014,39(5):857-859.
[8]Huo C,Liang H,Zhao Y,et al.Neolignan glycosides from Symplocos caudata[J].Phytochemistry,2008,69(3):788-795.
[9]Yan J,Ding L,Shi X,et al.Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACEinhibitory activity[J].Fitoterapia,2017,116:121-125.
[10]Gao P,Li L,Peng Y,et al.Monoterpene and lignan glycosides in the leaves of Crataegus pinnatifida[J].Biochem Syst Ecol,2010,38(5):988-992.
[2]王起文,马赟,马程遥,等.蝉翼藤化学成分及药理活性研究进展[J].中成药,2016,38(9):2013-2017.
[3]左坚.蝉翼藤抗风湿活性物质基础及作用机制研究[D].南京:南京中医药大学,2015.
[4]李勇文.五味藤的抗炎免疫镇痛作用研究及机制初探[D].南宁:广西医科大学,2005.
[5]李勇文,李丽,李植飞,等.蝉翼藤对小鼠脾细胞体外增殖和淋巴因子分泌水平的影响[J].中国中医药信息杂志,2006,13(5):42-43.
[6]张连涛,梁贤栋,周文亮,等.蝉翼藤有机酸提取物抑制鸭体内乙型肝炎病毒复制及保肝作用的研究[J].中华临床医师杂志,2013(23):10766-10769.
[7]贺兰云,黄海疆.红茴香甲醇部位化学成分研究[J].中国中药杂志,2014,39(5):857-859.
[8]Huo C,Liang H,Zhao Y,et al.Neolignan glycosides from Symplocos caudata[J].Phytochemistry,2008,69(3):788-795.
[9]Yan J,Ding L,Shi X,et al.Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACEinhibitory activity[J].Fitoterapia,2017,116:121-125.
[10]Gao P,Li L,Peng Y,et al.Monoterpene and lignan glycosides in the leaves of Crataegus pinnatifida[J].Biochem Syst Ecol,2010,38(5):988-992.