罗汉果及其功能成分干预糖脂代谢异常的分子机理研究进展
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摘要
罗汉果不仅是一种新型的功能性甜味剂,还是一种具有多种生理功能的传统药食两用中药材。本文首先综述了近年来国内外学者对罗汉果的生长特性、其主要功能成分的分类、生物活性及其功能产品的研发和应用现状,然后介绍了罗汉果及其功能成分在体内的消化、吸收、代谢及药物动力学等特性,最后重点总结了罗汉果及其功能成分干预糖脂代谢异常的动物及人体效果并在细胞层次分析了其可能存在的分子机制。本文为罗汉果及其功能成分的进一步研究与开发,特别是其在临床上的广泛应用提供扎实的理论指导和可靠的分子依据。
Siraitia grosvenorii is not only a new type of functional sweetener,but also a kind of traditional Chinese medicine with multiple physiological functions. This paper firstly analyzes the growth characteristics of Siraitia grosvenorii,the classification,the biological activity,the development and the application status of its functional components. Secondly,analyzes the digestion,absorption,metabolism and pharmacokinetic properties of Siraitia grosvenorii and its active components based on a plenty of researches. Finally,focuses on the effects of Siraitia grosvenorii and its functional components on the abnormal effects of glucose and lipid metabolism in animals and human body and analyzes its possible molecular mechanisms at the cellular level. This paper provides a solid theoretical guidance and reliable molecular basis for the further research and development of Siraitia grosvenorii and its functional components,especially its wide application in clinical practice.
Siraitia grosvenorii is not only a new type of functional sweetener,but also a kind of traditional Chinese medicine with multiple physiological functions. This paper firstly analyzes the growth characteristics of Siraitia grosvenorii,the classification,the biological activity,the development and the application status of its functional components. Secondly,analyzes the digestion,absorption,metabolism and pharmacokinetic properties of Siraitia grosvenorii and its active components based on a plenty of researches. Finally,focuses on the effects of Siraitia grosvenorii and its functional components on the abnormal effects of glucose and lipid metabolism in animals and human body and analyzes its possible molecular mechanisms at the cellular level. This paper provides a solid theoretical guidance and reliable molecular basis for the further research and development of Siraitia grosvenorii and its functional components,especially its wide application in clinical practice.
引文
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[3]李琦,肖聪.罗汉果糖类成分的含量测定[A].中华中医药学会会议论文集,2008.
[4]黎霜,王恒山,张桂勇,等.罗汉果种子油化学成分研究[J].广西医学,2003,25(5):850-852.
[5]秦愫妮,黄俊杰,全洗强,等.ICP-OES/ICP-MS法测定罗汉果中46种元素[J].食品工业科技,2017,38(18):242-246.
[6]张宏,李啸红.罗汉果化学成分研究进展[J].安徽农业科学,2011,39(8):4555-4556,4559.
[7]Takemoto T,Arihara S,Nakajima T,et al.Studies on the constituents of Fructus Momordicae.I.on the sweet principle[J].Yakugaku Zasshi,1983,103(11):1151-1154.
[8]Takemoto T,Arihara S,Nakajima T,et al.Studies on the constituents of Fructus Momordicae.II.on the sweet principle[J].Yakugaku Zasshi,1983,103(11):1155-1166.
[9]Takemoto T,Arihara S,Nakajima T,et al.Studies on the constituents of Fructus Momordicae.III.on the sweet principle[J].Yakugaku Zasshi,1983,103(11):1167-1173.
[10]斯建勇,陈迪华,沈连钢,等.广西特产植物罗汉果根的化学成分研究[J].药学学报,1999,34(12):918-920.
[11]Matsumoto K,Kasai R,Ohtani K,et al.Minor cucurbitane-glycosides from fruits of Siraitia grosvenorii(Cucurbitaceae)[J].Chem Pharm Bull,1990,38(7):2030-2032.
[12]卢曦,曾建红,申响宝,等.罗汉果悬浮培养细胞的生长和罗汉果甜苷积累的动力学研究[J].中国实验方剂学杂志,2011,15:235-237.
[13]李典鹏,陈月圆,潘争红,等.不同生长日龄罗汉果甙类成分变化研究[J].广西植物,2004,24(6):546-549.
[14]陈全斌,义祥辉,余丽娟,等.不同生长周期的罗汉果鲜果中甜甙V和总黄酮含量变化规律研究[J].广西植物,2005,25(3):274-277.
[15]张彩霞,戎敢,张志刚,等.罗汉果花中黄酮的提取及结构表征[J].光谱实验室,2013,30(3):1389-1393.
[16]饶荣,杨若婧,邓媛媛,等.罗汉果果实、茎叶总黄酮的含量测定[J].中国药师,2012,15(1):7-8.
[17]陈全斌,杨瑞云,义祥辉,等.RP-HPLC法测定罗汉果鲜果及甜甙中总黄酮含量[J].食品科学,2003,24(5):133-135.
[18]陈全斌,罗星晔,梁国秋,等.同期罗汉果植株不同部位黄酮含量测试研究[J].广西轻工业,2007(10):1-2.
[19]钟名诚,肖聪.HPLC测定罗汉果中山柰酚的含量[A].中华中医药学会会议论文集,2008.
[20]赵燕.罗汉果浓缩汁及罗汉果甜苷防龋性实验研究[J].食品研究与开发,2010,31(2):87-90.
[21]刘灿,蔡天宇,赵晓萌,等.罗汉果提取物诱导肺癌细胞A594凋亡的研究[J].中国药理学通报,2015,31(9):1310-1313.
[22]王勤,王坤,戴盛明,等.罗汉果甜甙对小鼠细胞免疫功能的调节作用[J].中药材,2011,24(11):811-812.
[23]Shi D F,Wang Y M,Chen S,et al.Protective effect sand mechanisms of mogroside V on LPS-induced acute lung injury in mice[J].Pharmaceutical Biology,2014,52(6):729-734.
[24]Liu C,Dai L H,Dou D Q,et al.A natural food sweetener with anti-pancreatic cancer properties[J].Oncogenesis,2016,6(4):e217.
[25]肖刚,王勤.罗汉果甜苷对小鼠实验性肝损伤保护作用的研究[J].中国药房,2008,19(3):163.
[26]陈全斌,沈钟苏,韦正波,等.罗汉果黄酮的活血化瘀药理作用研究[J].广西科学,2005,12(4):316-319.
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