当归芍药散联合寿胎丸治疗胎停育的临床效果
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摘要
目的:分析当归芍药散联合寿胎丸治疗胎停育的临床效果。方法:2016年1月—2018年5月本院收治的胎停育患者400例,随机分为观察组及对照组各200例,对照组行常规西药治疗,观察组采用当归芍药散联合寿胎丸对症治疗,比较两组治疗效果。结果:两组治疗2～3月后观察组治疗有效率(85.0%)高于对照组(55.0%),两组子宫内膜厚度、雌二醇(E_2)及孕酮(P)均有所提高,且观察组改善程度优于对照组,观察组血管内皮因子(VEGF)水平(120.8±8. 5pg/ml)高于对照组(113.3±7.4pg/ml)(均P>0.05)。结轮:当归芍药散合寿胎丸治疗胎停育可提高患者体质,修复子宫内膜损伤,疗效确切,可在临床探索应用。
Objective: To analyze the clinical efficacy of Danggui shaoyao powder and Shoutai pill for treating pregnant women with fetal death. Methods: From January 2016 to May 2018, 400 pregnant women with fetal death were enrolled and were randomly divided into the study group and the control group(200 cases in each group). The women in the control group were treated by conventional western medicine, and the women in the study group were treated by Danggui shaoyao powder combined with Shoutai pill. The treatment efficacy was compared between the two groups. Results: 2-3 months after treatment, the effective rate of women in the study group was 85.0%,which was significant higher than that of women(55.0%) in the control group(P<0.05). After treatment, the endometrial thickness and the levels of resume estradiol and progesterone of women had significantly increased in both groups, and those of women in the study group were better than those of women in control group. The VEGF level of women in the study group(120.8±8.5 pg/ml) was significant higher than that(113.3±7.4 pg/ml) of women in control group(P<0.05). Conclusion: Danggui shaoyao powder combined with Shoutai pill can significantly improve the physique of pregnant women with fetal death,and can help to repair their endometrial injury,which has efficacy and can be clinical application.
Objective: To analyze the clinical efficacy of Danggui shaoyao powder and Shoutai pill for treating pregnant women with fetal death. Methods: From January 2016 to May 2018, 400 pregnant women with fetal death were enrolled and were randomly divided into the study group and the control group(200 cases in each group). The women in the control group were treated by conventional western medicine, and the women in the study group were treated by Danggui shaoyao powder combined with Shoutai pill. The treatment efficacy was compared between the two groups. Results: 2-3 months after treatment, the effective rate of women in the study group was 85.0%,which was significant higher than that of women(55.0%) in the control group(P<0.05). After treatment, the endometrial thickness and the levels of resume estradiol and progesterone of women had significantly increased in both groups, and those of women in the study group were better than those of women in control group. The VEGF level of women in the study group(120.8±8.5 pg/ml) was significant higher than that(113.3±7.4 pg/ml) of women in control group(P<0.05). Conclusion: Danggui shaoyao powder combined with Shoutai pill can significantly improve the physique of pregnant women with fetal death,and can help to repair their endometrial injury,which has efficacy and can be clinical application.
引文
[1] 莫培晖,兰代群,闫志强.加减寿胎丸合四物汤对肾虚血瘀型复发性流产患者细胞免疫因子的影响[J].辽宁中医杂志,2018,45(6):1205-1207.
[2] 周静,陈萍.寿胎丸联合阿司匹林及泼尼松治疗复发性流产41例[J].西部中医药,2018,31(6):88-90.
[3] 柳娜.寿胎丸加减方治疗胎漏、胎动不安40例疗效观察[J].中国实用医药,2018,13(15):140-141.
[4] 高新源,王慧颖.基于补肾去瘀立论的改良加味寿胎丸治疗肾虚血瘀型胎动不安疗效观察[J].四川中医,2018,36(5):158-161.
[5] 何惠娟,严英,刘琰,等.寿胎丸合丹参加味方(颗粒)联合地屈孕酮治疗早期先兆流产合并宫腔积血(肾虚血瘀)随机平行对照研究[J].实用中医内科杂志,2018,32(4):34-37.
[6] 何冬华.寿胎丸合四物汤加减联合黄体酮治疗复发性流产肾虚血瘀型疗效观察[J].实用中医药杂志,2018,34(4):458-459.
[7] 刘昱磊,刘新玉,贝剑宏,等.紫河车联合寿胎丸加味治疗冷冻胚胎移植术后雌激素低下先兆流产患者临床研究[J].天津中医药,2018,35(3):175-178.
[8] 钮缓缓,程红.寿胎丸加减治疗肾虚型先兆流产临床疗效观察[J].中医药临床杂志,2018,30(2):324-326.
[9] 李雁南.寿胎丸加减联合西药治疗妊娠早期合并绒毛膜下血肿的先兆流产临床研究[J].光明中医,2018,33(4):565-566.
[10] 杨苗苗.寿胎丸联合黄体酮治疗先兆流产临床观察[J].实用中医药杂志,2018,34(2):199-200.
[11] 李丽娟,梁虹,王爱丽,等.寿胎丸合四物汤联合孕酮片对原因不明复发性流产患者细胞免疫因子的影响[J].世界中医药,2017,12(11):2713-2715+2719.
[12] 潘艳秋,丁超.寿胎丸合胎元饮加减治疗早期先兆流产合并宫腔血肿临床疗效观察[J].中国妇幼保健,2017,32(21):5429-5431.
[13] 曹卫平,师伟,李霞,等.加味寿胎丸联合黄体酮调节NKG2D、NKG2A表达治疗肾虚型URSA作用机制研究[J].南京中医药大学学报,2017,33(5):488-492.
[14] 魏竞男,王爱丽,陈彦,等.寿胎丸合四物汤加减治疗肾虚血瘀型复发性流产患者对细胞免疫因子的影响[J].辽宁中医杂志,2017,44(9):1887-1889.
[15] 余佩琳,刘新玉,刘昱磊,等.寿胎丸含药血清对自然流产患者滋养层细胞凋亡相关蛋白表达的影响[J].中医杂志,2017,58(18):1590-1593.
[2] 周静,陈萍.寿胎丸联合阿司匹林及泼尼松治疗复发性流产41例[J].西部中医药,2018,31(6):88-90.
[3] 柳娜.寿胎丸加减方治疗胎漏、胎动不安40例疗效观察[J].中国实用医药,2018,13(15):140-141.
[4] 高新源,王慧颖.基于补肾去瘀立论的改良加味寿胎丸治疗肾虚血瘀型胎动不安疗效观察[J].四川中医,2018,36(5):158-161.
[5] 何惠娟,严英,刘琰,等.寿胎丸合丹参加味方(颗粒)联合地屈孕酮治疗早期先兆流产合并宫腔积血(肾虚血瘀)随机平行对照研究[J].实用中医内科杂志,2018,32(4):34-37.
[6] 何冬华.寿胎丸合四物汤加减联合黄体酮治疗复发性流产肾虚血瘀型疗效观察[J].实用中医药杂志,2018,34(4):458-459.
[7] 刘昱磊,刘新玉,贝剑宏,等.紫河车联合寿胎丸加味治疗冷冻胚胎移植术后雌激素低下先兆流产患者临床研究[J].天津中医药,2018,35(3):175-178.
[8] 钮缓缓,程红.寿胎丸加减治疗肾虚型先兆流产临床疗效观察[J].中医药临床杂志,2018,30(2):324-326.
[9] 李雁南.寿胎丸加减联合西药治疗妊娠早期合并绒毛膜下血肿的先兆流产临床研究[J].光明中医,2018,33(4):565-566.
[10] 杨苗苗.寿胎丸联合黄体酮治疗先兆流产临床观察[J].实用中医药杂志,2018,34(2):199-200.
[11] 李丽娟,梁虹,王爱丽,等.寿胎丸合四物汤联合孕酮片对原因不明复发性流产患者细胞免疫因子的影响[J].世界中医药,2017,12(11):2713-2715+2719.
[12] 潘艳秋,丁超.寿胎丸合胎元饮加减治疗早期先兆流产合并宫腔血肿临床疗效观察[J].中国妇幼保健,2017,32(21):5429-5431.
[13] 曹卫平,师伟,李霞,等.加味寿胎丸联合黄体酮调节NKG2D、NKG2A表达治疗肾虚型URSA作用机制研究[J].南京中医药大学学报,2017,33(5):488-492.
[14] 魏竞男,王爱丽,陈彦,等.寿胎丸合四物汤加减治疗肾虚血瘀型复发性流产患者对细胞免疫因子的影响[J].辽宁中医杂志,2017,44(9):1887-1889.
[15] 余佩琳,刘新玉,刘昱磊,等.寿胎丸含药血清对自然流产患者滋养层细胞凋亡相关蛋白表达的影响[J].中医杂志,2017,58(18):1590-1593.