2014年江苏省江阴市职业暴露人群禽流感血清学调查
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摘要
目的了解江阴市职业暴露人群H5、H7、H9亚型禽流感病毒的感染状况,为制定人感染禽流感防控措施提供科学依据。方法采集监测人群血清,用马血球红细胞凝集抑制试验检测血清中的H5N1、H7N9、H9N2亚型禽流感病毒HI抗体,数据用Excel软件进行统计分析。结果共调查职业暴露人群80人,血清学结果显示14份标本H7N9和27份H9N2亚型禽流感病毒中和抗体阳性,总阳性率为45. 00%。职业暴露人群和对照组人群HI抗体效价阳性率差异有统计学意义(χ2=10. 98,P <0. 05)。问卷调查显示人群年龄偏大、文化水平偏低、流感疫苗接种率为0. 00%,防护意识较差。结论职业暴露人群存在H7N9和H9N2隐性感染现象,应加强健康教育,提高防护意识,同时加强职业人群和外环境监测,降低禽流感感染风险。
Objective To understand the infection status of avian influenza A( H5,H7 and H9) virus in occupational exposure population in Jiangyin,so as to provide scientific basis for the prevention and control of human infected avian influenza A virus( AIV). Methods The serum of the monitoring population was collected. The HI antibodies of H5 N1,H7 N9,H9 N2 subtype avian influenza virus in serum were detected with the red blood cell agglutination inhibition test. Excel software was used to analyze the results statistically. Results A total of 80 occupational exposure populations were investigated. Serological results showed that 41 out of 80 sera samples were detected positive for the neutralizing antibody of AIV( 45. 00%),which were 14 of H7 N9 subtupe and 27 of H9 N2 subtup. There was a statistically significant difference between occupational exposure and control group in AIV of H9 N2 subtype( χ2= 10. 98,P < 0. 05). Questionnaire survey showed that the exposure persons were older,the cultural level was low,the flu vaccination rate was 0. 00%,and the protection awareness was poorer. Conclusion There are infection case of AIV( H7 N9 and H9 N2 subtype) in the occupational exposure population in Jiangyin. Health education should be strengthened to improve protection awareness. At the same time,the monitoring of the occupational population and external environment should be strengthened to reduce the risk of avian influenza infection.
Objective To understand the infection status of avian influenza A( H5,H7 and H9) virus in occupational exposure population in Jiangyin,so as to provide scientific basis for the prevention and control of human infected avian influenza A virus( AIV). Methods The serum of the monitoring population was collected. The HI antibodies of H5 N1,H7 N9,H9 N2 subtype avian influenza virus in serum were detected with the red blood cell agglutination inhibition test. Excel software was used to analyze the results statistically. Results A total of 80 occupational exposure populations were investigated. Serological results showed that 41 out of 80 sera samples were detected positive for the neutralizing antibody of AIV( 45. 00%),which were 14 of H7 N9 subtupe and 27 of H9 N2 subtup. There was a statistically significant difference between occupational exposure and control group in AIV of H9 N2 subtype( χ2= 10. 98,P < 0. 05). Questionnaire survey showed that the exposure persons were older,the cultural level was low,the flu vaccination rate was 0. 00%,and the protection awareness was poorer. Conclusion There are infection case of AIV( H7 N9 and H9 N2 subtype) in the occupational exposure population in Jiangyin. Health education should be strengthened to improve protection awareness. At the same time,the monitoring of the occupational population and external environment should be strengthened to reduce the risk of avian influenza infection.
引文
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[6]闭福银,谭毅,陈敏玫,等. 2010-2011年广西禽流感职业高危人群及活禽市场监测结果分析[J].中国人兽共患病学报,2013,29(4):408-411.
[7]程慧健,袁辉,宗俊,等.江西省2004-2005年禽流感(H5N1)高危暴露人群感染状况调查[J].现代预防医学,2011,38(15):3073-3074.
[8]王英,孔雯骅,朱洪浩,等.武汉市外环境中禽流行性感冒病毒分布及禽类职业暴露人群H5N1抗体水平调查[J].中华预防医学杂志,2011,45(12):1082-1085.
[9]显传,余向华,余昭,等. 2009-2010年温州市瓯海区职业暴露人群禽流感监测分析[J].现代实用医学,2012,24(1):79-81.
[10]吴久鸿,胡春梅,史宁.国内外人禽流感预防概论[J].解放军药学学报,2006,22(1):44-47.
[11]崔兰梅,于海柱,项娜,等.北京市房山区201名禽流感职业暴露人群知信行调查[J].职业与健康,2010,22(3):316-318.
[2] GAO R,CAO B,HU Y,et al. Human infection with a novel avianorigin influenza A(H7N9)virus[J]. The New England journal of medicine,2013,368(20):1888-1897.
[3]叶夏良,雷永良,陈燕飞,等.浙江省丽水市职业暴露人群禽流感血清学调查[J].中国卫生检验杂志,2016,26(18):2703-2705.
[4]高强,苏琦,范刚,等. 2011-2013年淮安市职业暴露人群血清学和环境禽流感监测分析[J].现代预防医学,2015,42(3):410-411,464.
[5]崔小波,王定芳,方正斌,等. 2011年郧县禽流感高危职业人群及外环境监测结果分析[J].实用预防医学,2012,19(2):252-253.
[6]闭福银,谭毅,陈敏玫,等. 2010-2011年广西禽流感职业高危人群及活禽市场监测结果分析[J].中国人兽共患病学报,2013,29(4):408-411.
[7]程慧健,袁辉,宗俊,等.江西省2004-2005年禽流感(H5N1)高危暴露人群感染状况调查[J].现代预防医学,2011,38(15):3073-3074.
[8]王英,孔雯骅,朱洪浩,等.武汉市外环境中禽流行性感冒病毒分布及禽类职业暴露人群H5N1抗体水平调查[J].中华预防医学杂志,2011,45(12):1082-1085.
[9]显传,余向华,余昭,等. 2009-2010年温州市瓯海区职业暴露人群禽流感监测分析[J].现代实用医学,2012,24(1):79-81.
[10]吴久鸿,胡春梅,史宁.国内外人禽流感预防概论[J].解放军药学学报,2006,22(1):44-47.
[11]崔兰梅,于海柱,项娜,等.北京市房山区201名禽流感职业暴露人群知信行调查[J].职业与健康,2010,22(3):316-318.