声波喷雾离子化质谱技术及其应用研究进展
|
摘要
声波喷雾离子化技术是较早发展起来的一种软电离技术,该技术无需电压、加热、激光、电晕放电等辅助方式,常温常压条件下只需要通入与毛细管同轴的高速气体便可以实现喷雾离子化。作为一种新型常压离子源,该技术发展之初主要作为液相色谱-质谱联用技术的接口被广泛应用。基于声波喷雾离子化的原理,后续又发展了多种简易敞开式声波喷雾离子化衍生技术,无需或仅需要简单样品前处理即可实现样品的原位、快速、实时分析。本文阐述了声波喷雾离子化的原理和特点,并对其在生命科学、食品安全、法庭化学、反应监测等相关领域的应用研究进展进行了综述。
Sonic-spray ionization( SSI) is one of the simplest and most easily implemented ionization techniques. It relies solely on a high-velocity stream of nebulizing gas coaxial to spray capillary for ion formation with no assistance of externally applied ionization energies( e. g.,voltage,heating,ultraviolet radiation,laser beams, corona or glow discharges), which are normally required for other ionization techniques. Gaseous ions are produced at room temperature and under atmospheric pressure due to a statistically unbalanced distribution of charges in the tiny droplets by the pneumatic spray. SSI has been originally used as an atmospheric ion source interface for liquid chromatography-mass spectrometry( LC-MS).The results obtained with the SSI interface are similar to those obtained with electrospray ionization( ESI). The SSI can produce both positive and negative charged droplets duo to the ion concentration distribution model.This will be beneficial for high-throughput MS analysis. Ambient ionization has been developed for rapid and direct MS analysis of analytes in untreated samples in their native environment,and opens an exciting perspective on simplification of analysis procedures by creating ions outside the instrument. Based on the principle of SSI,researchers have developed desorption sonic-spray ionization( DeSSI) as a novel ambient ionization method. The high-velocity sonic spray facilitates matrix penetration, therefore providing more homogenous sampling and longer-lasting ion signals. DeSSI is later renamed to easy ambient sonic spray ionization( EASI),forming an acronym that makes a direct correlation to its easiness. After more than20 years of development,sonic-spray based ionization methods have shown a broad range of applications in an extremely wide array of specialities. Ranging from both qualitative and quantitative analyses to mass spectrometry imaging,the technique has shown unprecedented simplicity,speed,robustness and ease of use.This review elucidates the ionization mechanism of sonic-spray based ionization methods and reviews the wide applications of sonic-spray based ionization in the fields of life sciences,food safety,forensic chemistry,reaction monitoring,etc.
Sonic-spray ionization( SSI) is one of the simplest and most easily implemented ionization techniques. It relies solely on a high-velocity stream of nebulizing gas coaxial to spray capillary for ion formation with no assistance of externally applied ionization energies( e. g.,voltage,heating,ultraviolet radiation,laser beams, corona or glow discharges), which are normally required for other ionization techniques. Gaseous ions are produced at room temperature and under atmospheric pressure due to a statistically unbalanced distribution of charges in the tiny droplets by the pneumatic spray. SSI has been originally used as an atmospheric ion source interface for liquid chromatography-mass spectrometry( LC-MS).The results obtained with the SSI interface are similar to those obtained with electrospray ionization( ESI). The SSI can produce both positive and negative charged droplets duo to the ion concentration distribution model.This will be beneficial for high-throughput MS analysis. Ambient ionization has been developed for rapid and direct MS analysis of analytes in untreated samples in their native environment,and opens an exciting perspective on simplification of analysis procedures by creating ions outside the instrument. Based on the principle of SSI,researchers have developed desorption sonic-spray ionization( DeSSI) as a novel ambient ionization method. The high-velocity sonic spray facilitates matrix penetration, therefore providing more homogenous sampling and longer-lasting ion signals. DeSSI is later renamed to easy ambient sonic spray ionization( EASI),forming an acronym that makes a direct correlation to its easiness. After more than20 years of development,sonic-spray based ionization methods have shown a broad range of applications in an extremely wide array of specialities. Ranging from both qualitative and quantitative analyses to mass spectrometry imaging,the technique has shown unprecedented simplicity,speed,robustness and ease of use.This review elucidates the ionization mechanism of sonic-spray based ionization methods and reviews the wide applications of sonic-spray based ionization in the fields of life sciences,food safety,forensic chemistry,reaction monitoring,etc.
引文
1 Kambara H. Anal. Chem.,1982,54(1):187-195
2 Blakley C R,Vestal M L. Anal. Chem.,1983,55(4):750-754
3 Yamashita M,Fenn J B. J. Phys. Chem.,1984,88(20):4451-4459
4 Sakairi M,Kambara H. Anal. Chem.,1989,61(10):1159-1164
5 Hirabayashi A,Sakairi M,Koizumi H. Anal. Chem.,1994,66(24):4557-4559
6 Hirabayashi Y,Takada Y,Hirabayashi A,Sakairi M,Koizumi H. Rapid. Commun. Mass Spectrom.,1996,10(15):1891-1893
7 Hirabayashi Y,Hirabayashi A,Takada Y,Sakairi M,Koizumi H. Anal. Chem.,1998,70(9):1882-1884
8 Mortier K A,Dams R,Lambert W E,Letter E A D,Calenbergh S V,Leenheer A P D. Rapid. Commun. Mass Spectrom.,2002,16(9):865-870
9 Arinobu T,Hattori H,Seno H,Ishii A,Suzuki O. J. Am. Soc. Mass. Spectrom.,2002,13(3):204-208
10 Hirabayashi A. Rapid. Commun. Mass Spectrom.,2003,17(5):391-394
11 Kovcs Z,Dinya Z,Antus S. J. Chromatogr. Sci.,2004,42(3):125-129
12 Cooks R G,Ouyang Z,Takts Z,Wiseman J M. Science,2006,311(5767):1566-1570
13 Takts Z,Wiseman J M,Gologan B,Cooks R G. Science,2004,306(5695):471-473
14 Cody R B,Laramée J A,Durst H D. Anal. Chem.,2005,77(8):2297-2302
15 Haddad R,Sparrapan R,Eberlin M N. Rapid. Commun. Mass Spectrom.,2006,20(19):2901-2905
16 Haddad R,Milagre H M,Catharino R R,Eberlin M N. Anal. Chem.,2008,80(8):2744-2750
17 Haddad R,Sparrapan R,Kotiaho T,Eberlin M N. Anal. Chem.,2008,80(3):898-903
18 Hirabayashi A,Sakairi M,Koizumi H. Anal. Chem.,1995,67(17):2878-2882
19 Hirabayashi A,Hirabayashi Y,Sakairi M,Koizumi H. Rapid. Commun. Mass Spectrom.,2015,10(13):1703-1705
20 Dary C B L,Inés A V M,Elisa L C,Dazuly M. J. Chem. Phys.,1968,49(5):2240-2249
21 Kulys L. Bioelectroch. Bioener.,1993,31(3):330-331
22 Dodd E E. J. Appl. Phys.,1953,24(1):73-80
23 Katta V,Rockwood A L,Vestal M L. Int. J. Mass Spectrom. Ion. Process.,1991,103(2-3):129-148
24 Whitehouse D R. Anal. Chim. Acta,1966,36(1):412-416
25 Ozdemir A,Lin J L,Wang Y,Chen C H. RSC Adv.,2014,4(106):61290-61297
26 Alberici R M,Simas R C,Sanvido G B,Rom2o W,Lalli P M,Benassi M,Cunha I B S,Eberlin M N. Anal. Bioanal.Chem.,2010,398(1):265-271
27 Santos V G,Regiani T,Dias F F,Rom2o W,Jara J L,Klitzke C F,Coelho F,Eberlin M N. Anal. Chem.,2011,83(4):1375-1380
28 Schwab N V,Porcari A M,Coelho M B,Schmidt E M,Jara J L,Visentainer J V,Eberlin M N. Analyst,2012,137(11):2537-2540
29 Schwab N V,Eberlin M N. Drug. Test. Anal,2013,5(3):137-144
30 Bj9rkman H T,Edlund P O,Jacobsson S P. Anal. Chim. Acta,2002,468(2):263-274
31 Dams R,Benijts T,Günther W,Lambert W,De L A. Anal. Chem.,2002,74(13):3206-3212
32 Pól J,Kauppila T J,Haapala M,Saarela V,Franssila S,Ketola R A,Kotiaho T,Kostiainen R. Anal. Chem.,2007,79(9):3519-3523
33 Yu C L,Qian X,Chen Y,Yu Q,Ni K,Wang X H. RSC Adv.,2016,6(55):50180-50189
34 Eberlin L S,Abdelnur P V,Passero A,Sa G F,Daroda R J,Souza V,Eberlin M N. Analyst,2009,134(8):1652-1657
35 Figueiredo E C,Sanvido G B,Arruda M A,Eberlin M N. Analyst,2010,135(4):726-730
36 Shinozuka T,Terada M,Tanaka E. Forensic Sci. Int.,2006,162(1):108-112
37 Gréen H,Vretenbrant K,Norlander B,Peterson C. Rapid. Commun. Mass. Spectrom.,2010,20(14):2183-2189
38 Huang M,Hirabayashi A,Okumura A,Hirabayashi Y. Japan. Soc. Anal. Chem.,2001,17(10):1179-1182
39 Huang M,Hirabayashi A. Japan. Soc. Anal. Chem.,2002,18(4):385-387
40 Schfer K C,Balog J,SzaniszlóT,Szalay D,Mezey G,Dénes J,Bognr L,Oertel M,Takts Z. Anal. Chem.,2011,83(20):7729-7735
41 Arao T,Fuke C,Takaesu H,Nakamoto M,Morinaga Y,Miyazaki T. J. Anal. Toxicol.,2002,26(4):222-227
42 Arinobu T,Ishii A,Suzuki O,Hattori H,Kumazawa T,Lee X P,Kojima S,Seno H. Anal. Chim. Acta,2003,492(1):249-252
43 Alberici L C,Oliveira H C F,Catharino R R,Vercesi A E,Eberlin M N,Alberici R M. Anal. Bioanal. Chem.,2011,401(5):1651-1655
44 Simas R C,Catharino R R,Cunha I B S,Cabral E C,BarreraA rellano D,Eberlin M N,Alberici R M. Analyst,2010,135(4):738-744
45 Porcari A M,Schwab N V,Alberici R M,Cabral E C,Moraes D R d,Montanher P F,Ferreira C R,Eberlin M N,Visentainer J V. Anal. Methods,2012,4(11):3551-3557
46 Porcari A M,Fernandes G D,Belaz K R A,Schwab N V,Santos V G,Alberici R M,Gromova V A,Eberlin M N,Lebedev A T,Tata A. Anal. Methods,2014,6(8):2436-2443
47 Fernandes G D,Moreda W,Barreraarellano D,Ruiz G C N Z,Ferreira P L,Eberlin M N,Alberici R M. J. Braz. Chem.Soc.,2014,25(9):1565-1570
48 Sawaya A C H F,Abdelnur P V,Eberlin M N,Kumazawa S,Mokryeon A,Bang K S,Nagaraja N,Bankova V S,Afrouzan H. Talanta,2010,81(1):100-108
49 Domin M A,Cody R B. Ambient Ionization Mass Spectrometry. Royal Society Chemistry Press,2014:2822-2826
50 Riccio M F,Saraiva S A,Marques L A,Alberici R,Haddad R,Moller J C,Eberlin M N,Catharino R R. Eur. J. Lipid Sci. Tech.,2010,112(4):434-438
51 Rom2o W,Vaz B G,Lalli P M,Bueno M I,Correa D N,Telles V L,de Castro E V,Eberlin M N. J. Forensic Sci.,2012,57(2):539-543
52 Garrett R,Schwab N V,Cabral E C,Henrique B V M,Ifa D R,Eberlin M N,Rezende C M. J. Braz. Chem. Soc.,2014,25(7):1172-1177
53 Schmidt E M,Franco M F,Regino K G,Lehmann E L,Arruda M A,Wf D C R,Borges R,De S W,Eberlin M N,Correa D N. Sci. Justice.,2014,54(6):459-464
54 Lalli P M,Sanvido G B,Garcia J S,Haddad R,Cosso R G,Maia D R J,Zacca J J,Maldaner A O,Eberlin M N.Analyst,2010,135(4):745-750
55 Cabral E C,Simas R C,Santos V G,Queiroga C L,Da C V,de SG F,Daroda R J,Eberlin M N. J. Am. Soc. Mass Spectrom.,2015,47(1):1-6
56 Haddad R,Catharino R R,Marques L A,Eberlin M N. Rapid. Commun. Mass Spectrom.,2010,22(22):3662-3666
57 Nrgaard A W,Vaz B G,Lauritsen F R,Eberlin M N. Rapid. Commun. Mass Spectrom.,2010,24(23):3441-3446
58 Guo Y L,Wang H Y,Zhao Z X. Curr. Org. Chem.,2011,15(21):3734-3749
59 Amaral P H,Fernandes R,Eberlin M N,H9ehr N F. J. Am. Soc. Mass Spectrom.,2015,46(12):1269-1273
60 Simas R C,Barreraarellano D,Eberlin M N,Catharino R R,Souza V,Alberici R M. J. Am. Oil. Chem. Soc.,2012,89(7):1193-1200
61 Liu Y,Zhang J,Nie H,Dong C,Li Z,Zheng Z,Bai Y,Liu H,Zhao J. Anal. Chem.,2014,86(14):7096-7102
62 Pereira G G,Alberici R M,Fernandes G D,Cunha I B S,Eberlin M N,Dobarganes M C,Daroda R J,Arellano D. Eur.J. Lipid. Sci. Tech.,2014,116(8):952-960
63 Na N,Shi R,Long Z,Lu X,Jiang F,Ouyang J. Talanta,2014,128:366-372
64 Liu N,Lu X,Yang Y,Yao C,Ning B,He D,He L,Ouyang J. Talanta,2015,143:240-244
65 Jansson E T,Dulay M T,Zare R N. Anal. Chem.,2016,88(12):6195-6198
66 Teunissen S F,Fernandes A M A P,Eberlin M N,Alberici R M. TrA C-Trend. Anal. Chem.,2017,90:135-141
67 Alberici R M,Vendramini P H,Eberlin M N. Anal. Methods,2017,9(34):5029-5036
2 Blakley C R,Vestal M L. Anal. Chem.,1983,55(4):750-754
3 Yamashita M,Fenn J B. J. Phys. Chem.,1984,88(20):4451-4459
4 Sakairi M,Kambara H. Anal. Chem.,1989,61(10):1159-1164
5 Hirabayashi A,Sakairi M,Koizumi H. Anal. Chem.,1994,66(24):4557-4559
6 Hirabayashi Y,Takada Y,Hirabayashi A,Sakairi M,Koizumi H. Rapid. Commun. Mass Spectrom.,1996,10(15):1891-1893
7 Hirabayashi Y,Hirabayashi A,Takada Y,Sakairi M,Koizumi H. Anal. Chem.,1998,70(9):1882-1884
8 Mortier K A,Dams R,Lambert W E,Letter E A D,Calenbergh S V,Leenheer A P D. Rapid. Commun. Mass Spectrom.,2002,16(9):865-870
9 Arinobu T,Hattori H,Seno H,Ishii A,Suzuki O. J. Am. Soc. Mass. Spectrom.,2002,13(3):204-208
10 Hirabayashi A. Rapid. Commun. Mass Spectrom.,2003,17(5):391-394
11 Kovcs Z,Dinya Z,Antus S. J. Chromatogr. Sci.,2004,42(3):125-129
12 Cooks R G,Ouyang Z,Takts Z,Wiseman J M. Science,2006,311(5767):1566-1570
13 Takts Z,Wiseman J M,Gologan B,Cooks R G. Science,2004,306(5695):471-473
14 Cody R B,Laramée J A,Durst H D. Anal. Chem.,2005,77(8):2297-2302
15 Haddad R,Sparrapan R,Eberlin M N. Rapid. Commun. Mass Spectrom.,2006,20(19):2901-2905
16 Haddad R,Milagre H M,Catharino R R,Eberlin M N. Anal. Chem.,2008,80(8):2744-2750
17 Haddad R,Sparrapan R,Kotiaho T,Eberlin M N. Anal. Chem.,2008,80(3):898-903
18 Hirabayashi A,Sakairi M,Koizumi H. Anal. Chem.,1995,67(17):2878-2882
19 Hirabayashi A,Hirabayashi Y,Sakairi M,Koizumi H. Rapid. Commun. Mass Spectrom.,2015,10(13):1703-1705
20 Dary C B L,Inés A V M,Elisa L C,Dazuly M. J. Chem. Phys.,1968,49(5):2240-2249
21 Kulys L. Bioelectroch. Bioener.,1993,31(3):330-331
22 Dodd E E. J. Appl. Phys.,1953,24(1):73-80
23 Katta V,Rockwood A L,Vestal M L. Int. J. Mass Spectrom. Ion. Process.,1991,103(2-3):129-148
24 Whitehouse D R. Anal. Chim. Acta,1966,36(1):412-416
25 Ozdemir A,Lin J L,Wang Y,Chen C H. RSC Adv.,2014,4(106):61290-61297
26 Alberici R M,Simas R C,Sanvido G B,Rom2o W,Lalli P M,Benassi M,Cunha I B S,Eberlin M N. Anal. Bioanal.Chem.,2010,398(1):265-271
27 Santos V G,Regiani T,Dias F F,Rom2o W,Jara J L,Klitzke C F,Coelho F,Eberlin M N. Anal. Chem.,2011,83(4):1375-1380
28 Schwab N V,Porcari A M,Coelho M B,Schmidt E M,Jara J L,Visentainer J V,Eberlin M N. Analyst,2012,137(11):2537-2540
29 Schwab N V,Eberlin M N. Drug. Test. Anal,2013,5(3):137-144
30 Bj9rkman H T,Edlund P O,Jacobsson S P. Anal. Chim. Acta,2002,468(2):263-274
31 Dams R,Benijts T,Günther W,Lambert W,De L A. Anal. Chem.,2002,74(13):3206-3212
32 Pól J,Kauppila T J,Haapala M,Saarela V,Franssila S,Ketola R A,Kotiaho T,Kostiainen R. Anal. Chem.,2007,79(9):3519-3523
33 Yu C L,Qian X,Chen Y,Yu Q,Ni K,Wang X H. RSC Adv.,2016,6(55):50180-50189
34 Eberlin L S,Abdelnur P V,Passero A,Sa G F,Daroda R J,Souza V,Eberlin M N. Analyst,2009,134(8):1652-1657
35 Figueiredo E C,Sanvido G B,Arruda M A,Eberlin M N. Analyst,2010,135(4):726-730
36 Shinozuka T,Terada M,Tanaka E. Forensic Sci. Int.,2006,162(1):108-112
37 Gréen H,Vretenbrant K,Norlander B,Peterson C. Rapid. Commun. Mass. Spectrom.,2010,20(14):2183-2189
38 Huang M,Hirabayashi A,Okumura A,Hirabayashi Y. Japan. Soc. Anal. Chem.,2001,17(10):1179-1182
39 Huang M,Hirabayashi A. Japan. Soc. Anal. Chem.,2002,18(4):385-387
40 Schfer K C,Balog J,SzaniszlóT,Szalay D,Mezey G,Dénes J,Bognr L,Oertel M,Takts Z. Anal. Chem.,2011,83(20):7729-7735
41 Arao T,Fuke C,Takaesu H,Nakamoto M,Morinaga Y,Miyazaki T. J. Anal. Toxicol.,2002,26(4):222-227
42 Arinobu T,Ishii A,Suzuki O,Hattori H,Kumazawa T,Lee X P,Kojima S,Seno H. Anal. Chim. Acta,2003,492(1):249-252
43 Alberici L C,Oliveira H C F,Catharino R R,Vercesi A E,Eberlin M N,Alberici R M. Anal. Bioanal. Chem.,2011,401(5):1651-1655
44 Simas R C,Catharino R R,Cunha I B S,Cabral E C,BarreraA rellano D,Eberlin M N,Alberici R M. Analyst,2010,135(4):738-744
45 Porcari A M,Schwab N V,Alberici R M,Cabral E C,Moraes D R d,Montanher P F,Ferreira C R,Eberlin M N,Visentainer J V. Anal. Methods,2012,4(11):3551-3557
46 Porcari A M,Fernandes G D,Belaz K R A,Schwab N V,Santos V G,Alberici R M,Gromova V A,Eberlin M N,Lebedev A T,Tata A. Anal. Methods,2014,6(8):2436-2443
47 Fernandes G D,Moreda W,Barreraarellano D,Ruiz G C N Z,Ferreira P L,Eberlin M N,Alberici R M. J. Braz. Chem.Soc.,2014,25(9):1565-1570
48 Sawaya A C H F,Abdelnur P V,Eberlin M N,Kumazawa S,Mokryeon A,Bang K S,Nagaraja N,Bankova V S,Afrouzan H. Talanta,2010,81(1):100-108
49 Domin M A,Cody R B. Ambient Ionization Mass Spectrometry. Royal Society Chemistry Press,2014:2822-2826
50 Riccio M F,Saraiva S A,Marques L A,Alberici R,Haddad R,Moller J C,Eberlin M N,Catharino R R. Eur. J. Lipid Sci. Tech.,2010,112(4):434-438
51 Rom2o W,Vaz B G,Lalli P M,Bueno M I,Correa D N,Telles V L,de Castro E V,Eberlin M N. J. Forensic Sci.,2012,57(2):539-543
52 Garrett R,Schwab N V,Cabral E C,Henrique B V M,Ifa D R,Eberlin M N,Rezende C M. J. Braz. Chem. Soc.,2014,25(7):1172-1177
53 Schmidt E M,Franco M F,Regino K G,Lehmann E L,Arruda M A,Wf D C R,Borges R,De S W,Eberlin M N,Correa D N. Sci. Justice.,2014,54(6):459-464
54 Lalli P M,Sanvido G B,Garcia J S,Haddad R,Cosso R G,Maia D R J,Zacca J J,Maldaner A O,Eberlin M N.Analyst,2010,135(4):745-750
55 Cabral E C,Simas R C,Santos V G,Queiroga C L,Da C V,de SG F,Daroda R J,Eberlin M N. J. Am. Soc. Mass Spectrom.,2015,47(1):1-6
56 Haddad R,Catharino R R,Marques L A,Eberlin M N. Rapid. Commun. Mass Spectrom.,2010,22(22):3662-3666
57 Nrgaard A W,Vaz B G,Lauritsen F R,Eberlin M N. Rapid. Commun. Mass Spectrom.,2010,24(23):3441-3446
58 Guo Y L,Wang H Y,Zhao Z X. Curr. Org. Chem.,2011,15(21):3734-3749
59 Amaral P H,Fernandes R,Eberlin M N,H9ehr N F. J. Am. Soc. Mass Spectrom.,2015,46(12):1269-1273
60 Simas R C,Barreraarellano D,Eberlin M N,Catharino R R,Souza V,Alberici R M. J. Am. Oil. Chem. Soc.,2012,89(7):1193-1200
61 Liu Y,Zhang J,Nie H,Dong C,Li Z,Zheng Z,Bai Y,Liu H,Zhao J. Anal. Chem.,2014,86(14):7096-7102
62 Pereira G G,Alberici R M,Fernandes G D,Cunha I B S,Eberlin M N,Dobarganes M C,Daroda R J,Arellano D. Eur.J. Lipid. Sci. Tech.,2014,116(8):952-960
63 Na N,Shi R,Long Z,Lu X,Jiang F,Ouyang J. Talanta,2014,128:366-372
64 Liu N,Lu X,Yang Y,Yao C,Ning B,He D,He L,Ouyang J. Talanta,2015,143:240-244
65 Jansson E T,Dulay M T,Zare R N. Anal. Chem.,2016,88(12):6195-6198
66 Teunissen S F,Fernandes A M A P,Eberlin M N,Alberici R M. TrA C-Trend. Anal. Chem.,2017,90:135-141
67 Alberici R M,Vendramini P H,Eberlin M N. Anal. Methods,2017,9(34):5029-5036